Skip to main content
Canadian Journal of Veterinary Research logoLink to Canadian Journal of Veterinary Research
. 1998 Jul;62(3):231–233.

Prevalence of bovine immunodeficiency-like virus in bulls as determined by serology and proviral detection.

R M Jacobs 1, B J Jefferson 1, D L Suarez 1
PMCID: PMC1189481  PMID: 9684054

Abstract

We found the rate of bovine immunodeficiency-like virus (BIV) infection among bulls to be 9.6% using serology and 12.6% when tested by the polymerase chain reaction (PCR) for the presence of BIV provirus in peripheral blood leukocytes. Previously, we determined the frequency of BIV infection among the general dairy cow population in Ontario to be 5.5% based on serological analysis. Apparently, serological testing detects only 77% of BIV-infected bulls. Since almost a quarter of BIV-infected bulls may be seronegative, it is recommended that the PCR test be used to identify BIV-infected individuals. It is clear from the data presented here and supported by experimental studies that the latent carrier state is a relatively common outcome in ruminants infected with BIV.

Full text

PDF
231

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Bouillant A. M., Archambault D. Le virus de l'immunodéficience bovine: brève revue. Ann Rech Vet. 1990;21(4):239–250. [PubMed] [Google Scholar]
  2. Carpenter S., Miller L. D., Alexandersen S., Whetstone C. A., VanDerMaaten M. J., Viuff B., Wannemuehler Y., Miller J. M., Roth J. A. Characterization of early pathogenic effects after experimental infection of calves with bovine immunodeficiency-like virus. J Virol. 1992 Feb;66(2):1074–1083. doi: 10.1128/jvi.66.2.1074-1083.1992. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Flaming K., van der Maaten M., Whetstone C., Carpenter S., Frank D., Roth J. Effect of bovine immunodeficiency-like virus infection on immune function in experimentally infected cattle. Vet Immunol Immunopathol. 1993 Mar;36(2):91–105. doi: 10.1016/0165-2427(93)90100-i. [DOI] [PubMed] [Google Scholar]
  4. Gonda M. A., Braun M. J., Carter S. G., Kost T. A., Bess J. W., Jr, Arthur L. O., Van der Maaten M. J. Characterization and molecular cloning of a bovine lentivirus related to human immunodeficiency virus. 1987 Nov 26-Dec 2Nature. 330(6146):388–391. doi: 10.1038/330388a0. [DOI] [PubMed] [Google Scholar]
  5. Hirai N., Xuan S., Ochiai K., Onuma M. Alteration of immune responses of rabbits infected with bovine immunodeficiency-like virus. Microbiol Immunol. 1994;38(12):943–950. doi: 10.1111/j.1348-0421.1994.tb02151.x. [DOI] [PubMed] [Google Scholar]
  6. Isaacson J. A., Roth J. A., Wood C., Carpenter S. Loss of Gag-specific antibody reactivity in cattle experimentally infected with bovine immunodeficiency-like virus. Viral Immunol. 1995;8(1):27–36. doi: 10.1089/vim.1995.8.27. [DOI] [PubMed] [Google Scholar]
  7. Jacobs R. M., Pollari F. L., McNab W. B., Jefferson B. A serological survey of bovine syncytial virus in Ontario: associations with bovine leukemia and immunodeficiency-like viruses, production records, and management practices. Can J Vet Res. 1995 Oct;59(4):271–278. [PMC free article] [PubMed] [Google Scholar]
  8. Jacobs R. M., Smith H. E., Gregory B., Valli V. E., Whetstone C. A. Detection of multiple retroviral infections in cattle and cross-reactivity of bovine immunodeficiency-like virus and human immunodeficiency virus type 1 proteins using bovine and human sera in a western blot assay. Can J Vet Res. 1992 Oct;56(4):353–359. [PMC free article] [PubMed] [Google Scholar]
  9. Jacobs R. M., Smith H. E., Whetstone C. A., Suarez D. L., Jefferson B., Valli V. E. Haematological and lymphocyte subset analyses in sheep inoculated with bovine immunodeficiency-like virus. Vet Res Commun. 1994;18(6):471–482. doi: 10.1007/BF01839424. [DOI] [PubMed] [Google Scholar]
  10. Martin S. J., O'Neill T. P., Bilello J. A., Eiseman J. L. Lymphocyte transformation abnormalities in bovine immunodeficiency-like virus infected calves. Immunol Lett. 1991 Feb;27(2):81–84. doi: 10.1016/0165-2478(91)90132-t. [DOI] [PubMed] [Google Scholar]
  11. McNab W. B., Jacobs R. M., Smith H. E. A serological survey for bovine immunodeficiency-like virus in Ontario dairy cattle and associations between test results, production records and management practices. Can J Vet Res. 1994 Jan;58(1):36–41. [PMC free article] [PubMed] [Google Scholar]
  12. Nadin-Davis S. A., Chang S. C., Smith H., Jacobs R. M. Detection of bovine immunodeficiency-like virus by the polymerase chain reaction. J Virol Methods. 1993 May;42(2-3):323–336. doi: 10.1016/0166-0934(93)90043-q. [DOI] [PubMed] [Google Scholar]
  13. Nash J. W., Hanson L. A., St Cyr Coats K. Bovine immunodeficiency virus in stud bull semen. Am J Vet Res. 1995 Jun;56(6):760–763. [PubMed] [Google Scholar]
  14. Onuma M., Koomoto E., Furuyama H., Yasutomi Y., Taniyama H., Iwai H., Kawakami Y. Infection and dysfunction of monocytes induced by experimental inoculation of calves with bovine immunodeficiency-like virus. J Acquir Immune Defic Syndr. 1992 Oct;5(10):1009–1015. [PubMed] [Google Scholar]
  15. Pifat D. Y., Ennis W. H., Ward J. M., Oberste M. S., Gonda M. A. Persistent infection of rabbits with bovine immunodeficiency-like virus. J Virol. 1992 Jul;66(7):4518–4524. doi: 10.1128/jvi.66.7.4518-4524.1992. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. Rovid A. H., Carpenter S., Roth J. A. Monocyte function in cattle experimentally infected with bovine immunodeficiency-like virus. Vet Immunol Immunopathol. 1995 Mar;45(1-2):31–43. doi: 10.1016/0165-2427(94)05326-n. [DOI] [PubMed] [Google Scholar]
  17. Smith H. E., Jacobs R. M., Mallard B. Cell-mediated and humoral immunity in sheep exposed to bovine immunodeficiency-like virus. Comp Immunol Microbiol Infect Dis. 1994 Feb;17(1):29–39. doi: 10.1016/0147-9571(94)90004-3. [DOI] [PubMed] [Google Scholar]
  18. Smith H. E., Jacobs R. M. Serological evidence of bovine immunodeficiency-like virus infection in a sheep. Can J Vet Res. 1993 Oct;57(4):305–306. [PMC free article] [PubMed] [Google Scholar]
  19. Snider T. G., 3rd, Luther D. G., Jenny B. F., Hoyt P. G., Battles J. K., Ennis W. H., Balady J., Blas-Machado U., Lemarchand T. X., Gonda M. A. Encephalitis, lymphoid tissue depletion and secondary diseases associated with bovine immunodeficiency virus in a dairy herd. Comp Immunol Microbiol Infect Dis. 1996 Feb;19(2):117–131. doi: 10.1016/0147-9571(95)00032-1. [DOI] [PubMed] [Google Scholar]
  20. StCyr Coats K., Pruett S. B., Nash J. W., Cooper C. R. Bovine immunodeficiency virus: incidence of infection in Mississippi dairy cattle. Vet Microbiol. 1994 Nov;42(2-3):181–189. doi: 10.1016/0378-1135(94)90017-5. [DOI] [PubMed] [Google Scholar]
  21. Suarez D. L., Van der Maaten M. J., Whetstone C. A. Improved early and long-term detection of bovine lentivirus by a nested polymerase chain reaction test in experimentally infected calves. Am J Vet Res. 1995 May;56(5):579–586. [PubMed] [Google Scholar]
  22. Suarez D. L., Whetstone C. A. Comparison of different PCR tests to detect bovine lentivirus in cell culture and experimentally and naturally infected cattle. J Vet Diagn Invest. 1997 Oct;9(4):421–424. doi: 10.1177/104063879700900415. [DOI] [PubMed] [Google Scholar]
  23. Suarez D. L., Whetstone C. A. Identification of hypervariable and conserved regions in the surface envelope gene in the bovine lentivirus. Virology. 1995 Oct 1;212(2):728–733. doi: 10.1006/viro.1995.1532. [DOI] [PubMed] [Google Scholar]
  24. Suarez D. L., Whetstone C. A. Size variation within the second hypervariable region of the surface envelope gene of the bovine lentivirus BIV in experimentally and naturally infected cattle. J Virol. 1997 Mar;71(3):2482–2486. doi: 10.1128/jvi.71.3.2482-2486.1997. [DOI] [PMC free article] [PubMed] [Google Scholar]
  25. Van Der Maaten M. J., Whetstone C. A. Infection of rabbits with bovine immunodeficiency-like virus. Vet Microbiol. 1992 Feb;30(2-3):125–135. doi: 10.1016/0378-1135(92)90108-6. [DOI] [PubMed] [Google Scholar]
  26. Van der Maaten M. J., Boothe A. D., Seger C. L. Isolation of a virus from cattle with persistent lymphocytosis. J Natl Cancer Inst. 1972 Dec;49(6):1649–1657. doi: 10.1093/jnci/49.6.1649. [DOI] [PubMed] [Google Scholar]
  27. Walder R., Kalvatchev Z., Tobin G. J., Barrios M. N., Garzaro D. J., Gonda M. A. Possible role of bovine immunodeficiency virus in bovine paraplegic syndrome: evidence from immunochemical, virological and seroprevalence studies. Res Virol. 1995 Sep-Oct;146(5):313–323. doi: 10.1016/0923-2516(96)80594-2. [DOI] [PubMed] [Google Scholar]
  28. Whetstone C. A., VanDerMaaten M. J., Black J. W. Humoral immune response to the bovine immunodeficiency-like virus in experimentally and naturally infected cattle. J Virol. 1990 Jul;64(7):3557–3561. doi: 10.1128/jvi.64.7.3557-3561.1990. [DOI] [PMC free article] [PubMed] [Google Scholar]

Articles from Canadian Journal of Veterinary Research are provided here courtesy of Canadian Veterinary Medical Association

RESOURCES