Skip to main content
NCBI home page
Canadian Journal of Veterinary Research logoLink to Canadian Journal of Veterinary Research
. 1999 Jan;63(1):37–40.

Metoclopramide ameliorates the effects of endotoxin on gastric emptying of acetaminophen in horses.

T J Doherty 1, F M Andrews 1, T W Abraha 1, D Osborne 1, D L Frazier 1
PMCID: PMC1189513  PMID: 9918332

Abstract

The effect of metoclopramide on gastric emptying of a liquid marker in horses was evaluated by measuring serum concentrations of acetaminophen. Gastric emptying was determined in normal, fasted horses (n = 7), horses given endotoxin intravenously (n = 7), and horses given intravenous metoclopramide plus endotoxin (n = 6). The mean time to reach maximum serum acetaminophen concentration (Tmax), the maximum serum concentration (Cmax), and the area under the serum acetaminophen concentration vs time curve (AUC) were compared among treatment groups. Endotoxin caused a profound delay in gastric emptying, and pretreatment with metoclopramide significantly (P < 0.05) ameliorated this effect.

Full text

PDF
37

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Breslow M. J., Miller C. F., Parker S. D., Walman A. T., Traystman R. J. Effect of vasopressors on organ blood flow during endotoxin shock in pigs. Am J Physiol. 1987 Feb;252(2 Pt 2):H291–H300. doi: 10.1152/ajpheart.1987.252.2.H291. [DOI] [PubMed] [Google Scholar]
  2. Clements J. A., Heading R. C., Nimmo W. S., Prescott L. F. Kinetics of acetaminophen absorption and gastric emptying in man. Clin Pharmacol Ther. 1978 Oct;24(4):420–431. doi: 10.1002/cpt1978244420. [DOI] [PubMed] [Google Scholar]
  3. Dart A. J., Peauroi J. R., Hodgson D. R., Pascoe J. R. Efficacy of metoclopramide for treatment of ileus in horses following small intestinal surgery: 70 cases (1989-1992). Aust Vet J. 1996 Oct;74(4):280–284. doi: 10.1111/j.1751-0813.1996.tb13775.x. [DOI] [PubMed] [Google Scholar]
  4. Doherty T. J., Andrews F. M., Provenza M. K., Frazier D. L. Acetaminophen as a marker of gastric emptying in ponies. Equine Vet J. 1998 Jul;30(4):349–351. doi: 10.1111/j.2042-3306.1998.tb04109.x. [DOI] [PubMed] [Google Scholar]
  5. Eades S. C., Moore J. N. Blockade of endotoxin-induced cecal hypoperfusion and ileus with an alpha 2 antagonist in horses. Am J Vet Res. 1993 Apr;54(4):586–590. [PubMed] [Google Scholar]
  6. Gerring E. E., Hunt J. M. Pathophysiology of equine postoperative ileus: effect of adrenergic blockade, parasympathetic stimulation and metoclopramide in an experimental model. Equine Vet J. 1986 Jul;18(4):249–255. doi: 10.1111/j.2042-3306.1986.tb03618.x. [DOI] [PubMed] [Google Scholar]
  7. King J. N., Gerring E. L. Antagonism of endotoxin-induced disruption of equine bowel motility by flunixin and phenylbutazone. Equine Vet J Suppl. 1989 Jun;(7):38–42. doi: 10.1111/j.2042-3306.1989.tb05653.x. [DOI] [PubMed] [Google Scholar]
  8. King J. N., Gerring E. L. Detection of endotoxin in cases of equine colic. Vet Rec. 1988 Sep 3;123(10):269–271. doi: 10.1136/vr.123.10.269. [DOI] [PubMed] [Google Scholar]
  9. King J. N., Gerring E. L. The action of low dose endotoxin on equine bowel motility. Equine Vet J. 1991 Jan;23(1):11–17. doi: 10.1111/j.2042-3306.1991.tb02705.x. [DOI] [PubMed] [Google Scholar]
  10. Manninen V., Apajalahti A., Melin J., Karesoja M. Altered absorption of digoxin in patients given propantheline and metoclopramide. Lancet. 1973 Feb 24;1(7800):398–400. doi: 10.1016/s0140-6736(73)90252-3. [DOI] [PubMed] [Google Scholar]
  11. Mizuta H., Kawazoe Y., Haga K., Ogawa K. Effects of meals on gastric emptying and small intestinal transit times of a suspension in the beagle dog assessed using acetaminophen and salicylazosulfapyridine as markers. Chem Pharm Bull (Tokyo) 1990 Aug;38(8):2224–2227. doi: 10.1248/cpb.38.2224. [DOI] [PubMed] [Google Scholar]
  12. Moore J. N., Garner H. E., Shapland J. E., Hatfield D. G. Prevention of endotoxin-induced arterial hypoxaemia and lactic acidosis with flunixin meglumine in the conscious pony. Equine Vet J. 1981 Apr;13(2):95–98. doi: 10.1111/j.2042-3306.1981.tb04122.x. [DOI] [PubMed] [Google Scholar]
  13. Tonini M., Candura S. M., Messori E., Rizzi C. A. Therapeutic potential of drugs with mixed 5-HT4 agonist/5-HT3 antagonist action in the control of emesis. Pharmacol Res. 1995 May;31(5):257–260. doi: 10.1016/1043-6618(95)80029-8. [DOI] [PubMed] [Google Scholar]
  14. Valk N., Doherty T. J., Blackford J. T., Abraha T. W., Frazier D. L. Effect of cisapride on gastric emptying in horses following endotoxin treatment. Equine Vet J. 1998 Jul;30(4):344–348. doi: 10.1111/j.2042-3306.1998.tb04108.x. [DOI] [PubMed] [Google Scholar]
  15. Valk N., Doherty T. J., Blackford J. T., Abraha T. W., Frazier D. L. Phenylbutazone prevents the endotoxin-induced delay in gastric emptying in horses. Can J Vet Res. 1998 Jul;62(3):214–217. [PMC free article] [PubMed] [Google Scholar]

Articles from Canadian Journal of Veterinary Research are provided here courtesy of Canadian Veterinary Medical Association

RESOURCES