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. 2025 Feb 6;33(3):1301. doi: 10.1016/j.ymthe.2025.01.026

Retraction Notice to: Lentivirus Mediated Delivery of Neurosin Promotes Clearance of Wild-type α-Synuclein and Reduces the Pathology in an α-Synuclein Model of LBD

Brian Spencer, Sarah Michael, Jay Shen, Kori Kosberg, Edward Rockenstein, Christina Patrick, Anthony Adame, Eliezer Masliah
PMCID: PMC11897741  PMID: 39909031

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(Molecular Therapy 21, 31–41; January 2013)

This article has been retracted: please see Elsevier Policy on Article Withdrawal (https://www.elsevier.com/locate/withdrawalpolicy).

This article has been retracted at the request of the editor-in-chief. A third party posted image concerns involving Figures 6A and 6B on Pubpeer: https://pubpeer.com/publications/EA0BC802844FFC8FCE7B5F4AE28994. Image analysis performed by the editorial office revealed the following evidence of image manipulation:

1. Duplication of lanes in Figure 1G (α-syn)

2. Duplication of lanes in Figure 1I (Actin)

3. Apparent copying/pasting of elements within Figure 6A (actin)

4. Apparent copying/pasting of elements and splicing within Figure 6B

5. Apparent copying/pasting of elements and splicing within Figure 6C (actin)

6. Apparent splicing between lanes in Figure S1B.

The authors provided any available original data upon request; however, the initial concerns could not be alleviated. Thus, the editors have lost faith in the findings presented in this study. The original notice of retraction was undeliverable to authors A.A., S.M., and E.R. Authors B.S. and E.M. disagree with this retraction and dispute the grounds for it.


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