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. 1990 Jun;425:133–144. doi: 10.1113/jphysiol.1990.sp018096

Capsaicin-sensitive afferents activate a sympathetic intestinointestinal inhibitory reflex in dogs.

M Mizutani 1, T Neya 1, S Nakayama 1
PMCID: PMC1189841  PMID: 2213576

Abstract

1. In urethane-anaesthetized dogs, an intra-arterial infusion of capsaicin (0.7-14 nmol min-1) into a separated jejunal segment inhibited a vagally evoked cholinergic contraction of the other non-infused segments. The mechanism of this reflex was investigated. 2. The inhibition by capsaicin was abolished after bilateral splanchnic nerve section or cervical spinal cord transection (C5 or C6), but was unaffected by bilateral vagotomy. Decerebration partially reduced the inhibition. 3. The inhibition by capsaicin was abolished by pre-treatment with phentolamine or yohimbine, but was unaffected by prazosin or propranolol. 4. Sympathetic efferent discharge of the mesenteric nerve increased with capsaicin application, during which time vagally evoked contractions were inhibited. 5. Single-unit discharges of the major splanchnic and mesenteric afferents increased with capsaicin infusion to the loop which was innervated by the units. 6. Together the results implied that capsaicin stimulated canine intestinal primary afferents, resulting in the sympathetic intestinointestinal inhibitory reflex supraspinally. The inhibition of vagally evoked contractions may be due to a presynaptic inhibition via alpha 2-adrenoceptors, which are activated by the reflex.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Andréjak M., Pommier Y., Mouillé P., Schmitt H. Effects of some alpha-adrenoceptor agonists and antagonists on the guinea-pig ileum. Naunyn Schmiedebergs Arch Pharmacol. 1980 Oct;314(1):83–87. doi: 10.1007/BF00498434. [DOI] [PubMed] [Google Scholar]
  2. Baranowski R., Lynn B., Pini A. The effects of locally applied capsaicin on conduction in cutaneous nerves in four mammalian species. Br J Pharmacol. 1986 Oct;89(2):267–276. doi: 10.1111/j.1476-5381.1986.tb10256.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Bayliss W. M., Starling E. H. The movements and innervation of the small intestine. J Physiol. 1899 May 11;24(2):99–143. doi: 10.1113/jphysiol.1899.sp000752. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Blumberg H., Haupt P., Jänig W., Kohler W. Encoding of visceral noxious stimuli in the discharge patterns of visceral afferent fibres from the colon. Pflugers Arch. 1983 Jun;398(1):33–40. doi: 10.1007/BF00584710. [DOI] [PubMed] [Google Scholar]
  5. Buck S. H., Burks T. F. The neuropharmacology of capsaicin: review of some recent observations. Pharmacol Rev. 1986 Sep;38(3):179–226. [PubMed] [Google Scholar]
  6. Donnerer J., Lembeck F. Capsaicin-induced reflex fall in rat blood pressure is mediated by afferent substance P-containing neurones via a reflex centre in the brain stem. Naunyn Schmiedebergs Arch Pharmacol. 1983 Dec;324(4):293–295. doi: 10.1007/BF00502626. [DOI] [PubMed] [Google Scholar]
  7. Fagbemi S. O., Salako L. A. The effect of prazosin on the guinea-pig ileum. Br J Pharmacol. 1980 Nov;70(3):395–402. doi: 10.1111/j.1476-5381.1980.tb08715.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Giuliani S., Maggi C. A., Meli A. Capsaicin-sensitive afferents in the rat urinary bladder activate a spinal sympathetic cardiovascular reflex. Naunyn Schmiedebergs Arch Pharmacol. 1988 Oct;338(4):411–416. doi: 10.1007/BF00172119. [DOI] [PubMed] [Google Scholar]
  9. Holzer P. Capsaicin-sensitive afferent neurones and gastrointestinal propulsion in the rat. Naunyn Schmiedebergs Arch Pharmacol. 1986 Jan;332(1):62–65. doi: 10.1007/BF00633198. [DOI] [PubMed] [Google Scholar]
  10. Jancsó G., Such G. Effects of capsaicin applied perineurally to the vagus nerve on cardiovascular and respiratory functions in the cat. J Physiol. 1983 Aug;341:359–370. doi: 10.1113/jphysiol.1983.sp014810. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Kilbinger H., Wessler I. Increase by alpha-adrenolytic drugs of acetylcholine release evoked by field stimulation of the guinea-pig ileum. Naunyn Schmiedebergs Arch Pharmacol. 1979 Nov;309(3):255–257. doi: 10.1007/BF00504758. [DOI] [PubMed] [Google Scholar]
  12. Lembeck F., Skofitsch G. Visceral pain reflex after pretreatment with capsaicin and morphine. Naunyn Schmiedebergs Arch Pharmacol. 1982 Nov;321(2):116–122. doi: 10.1007/BF00518478. [DOI] [PubMed] [Google Scholar]
  13. Longhurst J. C., Ashton J. H., Iwamoto G. A. Cardiovascular reflexes resulting from capsaicin-stimulated gastric receptors in anesthetized dogs. Circ Res. 1980 Jun;46(6):780–788. doi: 10.1161/01.res.46.6.780. [DOI] [PubMed] [Google Scholar]
  14. Longhurst J. C., Kaufman M. P., Ordway G. A., Musch T. I. Effects of bradykinin and capsaicin on endings of afferent fibers from abdominal visceral organs. Am J Physiol. 1984 Sep;247(3 Pt 2):R552–R559. doi: 10.1152/ajpregu.1984.247.3.R552. [DOI] [PubMed] [Google Scholar]
  15. Longhurst J. C., Stebbins C. L., Ordway G. A. Chemically induced cardiovascular reflexes arising from the stomach of the cat. Am J Physiol. 1984 Sep;247(3 Pt 2):H459–H466. doi: 10.1152/ajpheart.1984.247.3.H459. [DOI] [PubMed] [Google Scholar]
  16. Maggi C. A., Meli A., Santicioli P. Four motor effects of capsaicin on guinea-pig distal colon. Br J Pharmacol. 1987 Apr;90(4):651–660. doi: 10.1111/j.1476-5381.1987.tb11217.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. Maggi C. A., Meli A. The sensory-efferent function of capsaicin-sensitive sensory neurons. Gen Pharmacol. 1988;19(1):1–43. doi: 10.1016/0306-3623(88)90002-x. [DOI] [PubMed] [Google Scholar]
  18. Maggi C. A., Santicioli P., Borsini F., Giuliani S., Meli A. The role of the capsaicin-sensitive innervation of the rat urinary bladder in the activation of micturition reflex. Naunyn Schmiedebergs Arch Pharmacol. 1986 Mar;332(3):276–283. doi: 10.1007/BF00504867. [DOI] [PubMed] [Google Scholar]
  19. Nakahata N., Nakanishi H., Suzuki T. Prejunctional inhibition mediated via alpha 2-adrenoceptors in excitatory transmission of canine small intestine. J Pharm Pharmacol. 1982 Aug;34(8):510–513. doi: 10.1111/j.2042-7158.1982.tb04775.x. [DOI] [PubMed] [Google Scholar]
  20. Ordway G. A., Longhurst J. C. Cardiovascular reflexes arising from the gallbladder of the cat. Effects of capsaicin, bradykinin, and distension. Circ Res. 1983 Jan;52(1):26–35. doi: 10.1161/01.res.52.1.26. [DOI] [PubMed] [Google Scholar]
  21. Ordway G. A., Longhurst J. C., Mitchell J. H. Stimulation of pancreatic afferents reflexly activates the cardiovascular system in cats. Am J Physiol. 1983 Dec;245(6):R820–R826. doi: 10.1152/ajpregu.1983.245.6.R820. [DOI] [PubMed] [Google Scholar]

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