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. 1989 Nov;418:251–259. doi: 10.1113/jphysiol.1989.sp017838

Sodium depletion decreases hepatic metabolism of vasoactive intestinal peptide in the rabbit.

K A Duggan 1, C M Hawley 1, G J Macdonald 1, S Shelley 1
PMCID: PMC1189969  PMID: 2621618

Abstract

1. Reports that a greater natriuresis occurs after gastric rather than intravenous sodium loads suggest that a gastric sodium monitor exists which releases a humoral natriuretic factor. As vasoactive intestinal peptide (VIP) is natriuretic, it might act as this mediator. To determine whether it released from the gut in response to sodium we measured VIP levels in portal and systemic plasma of anaesthetized rabbits after a gastric sodium load. Levels of VIP in systemic plasma were also measured in conscious rabbits after gastric and portal sodium loads to determine the contributions of anaesthesia or increased sodium concentration in the portal tract to any observed rise in systemic VIP levels. 2. In the anaesthetized rabbit study portal and systemic VIP levels had both increased significantly from control values by 5 min after the sodium load in the low salt diet group (P less than 0.025, portal: P less than 0.05, systemic). By 10 min the levels in systemic and portal plasma were equal. 3. In the conscious rabbits an increase in systemic VIP levels was observed in the group on a low salt diet after a gastric but not a portal sodium load. 4. We conclude that VIP is released in response to gastric sodium loads in rabbits on low salt diets and that hepatic metabolism of VIP is reduced in this group.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Bitar K. N., Said S. I., Weir G. C., Saffouri B., Makhlouf G. M. Neural release of vasoactive intestinal peptide from the gut. Gastroenterology. 1980 Dec;79(6):1288–1294. [PubMed] [Google Scholar]
  2. Carey R. M. Evidence for a splanchnic sodium input monitor regulating renal sodium excretion in man. Lack of dependence upon aldosterone. Circ Res. 1978 Jul;43(1):19–23. doi: 10.1161/01.res.43.1.19. [DOI] [PubMed] [Google Scholar]
  3. Carey R. M., Smith J. R., Ortt E. M. Gastrointestinal control of sodium excretion in sodium-depleted conscious rabbits. Am J Physiol. 1976 Jun;230(6):1504–1508. doi: 10.1152/ajplegacy.1976.230.6.1504. [DOI] [PubMed] [Google Scholar]
  4. Chayvialle J. A., Rayford P. L., Thompson J. C. Radioimmunoassay study of hepatic clearance and disappearance half-time of somatostatin and vasoactive intestinal peptide in dogs. Gut. 1981 Sep;22(9):732–737. doi: 10.1136/gut.22.9.732. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Dimaline R., Peart W. S., Unwin R. J. Effects of vasoactive intestinal polypeptide (VIP) on renal function and plasma renin activity in the conscious rabbit. J Physiol. 1983 Nov;344:379–388. doi: 10.1113/jphysiol.1983.sp014946. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Duggan K. A., Macdonald G. J. Vasoactive intestinal peptide: a direct renal natriuretic substance. Clin Sci (Lond) 1987 Feb;72(2):195–200. doi: 10.1042/cs0720195. [DOI] [PubMed] [Google Scholar]
  7. Ebeid A. M., Murray P., Soeters P. B., Fischer J. E. Release of VIP by calcium stimulation. Am J Surg. 1977 Jan;133(1):140–144. doi: 10.1016/0002-9610(77)90208-2. [DOI] [PubMed] [Google Scholar]
  8. Ebeid A. M., Soeters P. B., Murray P., Fischer J. E. Release of vasoactive intestinal peptide (VIP) by intraluminal osmotic stimuli. J Surg Res. 1977 Jul;23(1):25–30. doi: 10.1016/0022-4804(77)90185-8. [DOI] [PubMed] [Google Scholar]
  9. Lennane R. J., Carey R. M., Goodwin T. J., Peart W. S. A comparison of natriuresis after oral and intravenous sodium loading in sodium-depleted man: evidence for a gastrointestinal or portal monitor of sodium intake. Clin Sci Mol Med. 1975 Nov;49(5):437–440. doi: 10.1042/cs0490437. [DOI] [PubMed] [Google Scholar]
  10. Lennane R. J., Peart W. S., Carey R. M., Shaw J. A comparison on natriuresis after oral and intravenous sodium loading in sodium-depleted rabbits: evidence for a gastrointestinal or portal monitor of sodium intake. Clin Sci Mol Med. 1975 Nov;49(5):433–436. doi: 10.1042/cs0490433. [DOI] [PubMed] [Google Scholar]
  11. Misbin R. I., Wolfe M. M., Morris P., Buynitzky S. J., McGuigan J. E. Uptake of vasoactive intestinal peptide by rat liver. Am J Physiol. 1982 Aug;243(2):G103–G111. doi: 10.1152/ajpgi.1982.243.2.G103. [DOI] [PubMed] [Google Scholar]
  12. Rosa R. M., Silva P., Stoff J. S., Epstein F. H. Effect of vasoactive intestinal peptide on isolated perfused rat kidney. Am J Physiol. 1985 Nov;249(5 Pt 1):E494–E497. doi: 10.1152/ajpendo.1985.249.5.E494. [DOI] [PubMed] [Google Scholar]
  13. Schaffalitzky de Muckadell O. B., Fahrenkrug J., Holst J. J. Release of vasoactive intestinal polypeptide (VIP) by electric stimulation of the vagal nerves. Gastroenterology. 1977 Feb;72(2):373–375. [PubMed] [Google Scholar]

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