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. 1988 Oct;404:649–667. doi: 10.1113/jphysiol.1988.sp017311

Activation of feline spinal neurones by potentiated ventricular contractions and other mechanical cardiac stimuli.

R W Blair 1, R D Foreman 1
PMCID: PMC1190847  PMID: 3253445

Abstract

1. Neurones in the spinal cord were tested for responses to premature ventricular contractions (PVCs), produced by controlled electrical extra stimuli, and other mechanical stimuli applied to the heart. Thirty-eight neurones were antidromically activated from the medial medullary reticular formation and/or the caudal thalamus, and twenty-four neurones did not project to these sites. 2. Only those neurones excited by electrical stimulation of the left stellate ganglion were tested for responses to PVCs. A total of twenty neurones (32%) responded to electrically induced PVCs. Three major patterns of responses occurred. Three neurones exhibited an early burst and a late burst (or bursts) during the arrhythmia, one neurone fired only an early burst, and sixteen neurones responded with only a late burst. The early bursts occurred shortly after the onset of the compensatory pause accompanying the PVC; the late bursts were usually associated with the subsequent potentiated contraction, although the stimulus eliciting the burst must often have occurred late in the compensatory pause. 3. Responses to PVCs were only seen in neurones receiving C fibre and A delta fibre input. However, there were some neurones with both A delta and C input that did not respond to PVCs. No neurones with only A delta input responded to PVCs. 4. Neurones projecting to thalamus were less likely to respond to PVCs than either spinoreticular neurones or neurones with unidentified projections. 5. Neurones responsive to PVCs were likely to exhibit a cardiac rhythmicity in their spontaneous or evoked activity. 6. A total of 42% of tested neurones responded to a rapid infusion of saline into the heart, 52% had a cardiac receptive field, and 74% responded to aortic occlusion. A given neurone might respond to one or more of these stimuli, without responding to every mechanical stimulus tested. 7. Cervical vagotomy never abolished a response to PVCs, although either the spontaneous discharge rate or magnitude of response was sometimes altered. 8. Neurones responsive to PVCs were also responsive to intracardiac bradykinin. In addition, 95% of the neurones received convergent somatic input. 9. We conclude that about a third of spinal neurones excited by electrical stimulation of the left stellate ganglion receive information regarding mechanical, presumably innocuous, events in the heart. Most responsive neurones also receive somatic input and noxious cardiac input, and this information is transmitted to the thalamus, reticular formation, and probably to other spinal segments.

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Selected References

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  1. Ammons W. S., Blair R. W., Foreman R. D. Vagal afferent inhibition of primate thoracic spinothalamic neurons. J Neurophysiol. 1983 Oct;50(4):926–940. doi: 10.1152/jn.1983.50.4.926. [DOI] [PubMed] [Google Scholar]
  2. Ammons W. S., Blair R. W., Foreman R. D. Vagal afferent inhibition of spinothalamic cell responses to sympathetic afferents and bradykinin in the monkey. Circ Res. 1983 Nov;53(5):603–612. doi: 10.1161/01.res.53.5.603. [DOI] [PubMed] [Google Scholar]
  3. Baker D. G., Coleridge H. M., Coleridge J. C., Nerdrum T. Search for a cardiac nociceptor: stimulation by bradykinin of sympathetic afferent nerve endings in the heart of the cat. J Physiol. 1980 Sep;306:519–536. doi: 10.1113/jphysiol.1980.sp013412. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Blair R. W., Ammons W. S., Foreman R. D. Responses of thoracic spinothalamic and spinoreticular cells to coronary artery occlusion. J Neurophysiol. 1984 Apr;51(4):636–648. doi: 10.1152/jn.1984.51.4.636. [DOI] [PubMed] [Google Scholar]
  5. Blair R. W. Cardiac input to medullary reticular formation: neuronal responses to mechanical stimuli. Am J Physiol. 1986 Oct;251(4 Pt 2):R680–R689. doi: 10.1152/ajpregu.1986.251.4.R680. [DOI] [PubMed] [Google Scholar]
  6. Blair R. W., Shimizu T., Bishop V. S. The role of vagal afferents in the reflex control of the left ventricular refractory period in the cat. Circ Res. 1980 Mar;46(3):378–386. doi: 10.1161/01.res.46.3.378. [DOI] [PubMed] [Google Scholar]
  7. Blair R. W., Weber R. N., Foreman R. D. Characteristics of primate spinothalamic tract neurons receiving viscerosomatic convergent inputs in T3-T5 segments. J Neurophysiol. 1981 Oct;46(4):797–811. doi: 10.1152/jn.1981.46.4.797. [DOI] [PubMed] [Google Scholar]
  8. Blair R. W., Weber R. N., Foreman R. D. Responses of thoracic spinoreticular and spinothalamic cells to intracardiac bradykinin. Am J Physiol. 1984 Apr;246(4 Pt 2):H500–H507. doi: 10.1152/ajpheart.1984.246.4.H500. [DOI] [PubMed] [Google Scholar]
  9. Blair R. W., Weber R. N., Foreman R. D. Responses of thoracic spinothalamic neurons to intracardiac injection of bradykinin in the monkey. Circ Res. 1982 Jul;51(1):83–94. doi: 10.1161/01.res.51.1.83. [DOI] [PubMed] [Google Scholar]
  10. Brown A. M. Excitation of afferent cardiac sympathetic nerve fibres during myocardial ischaemia. J Physiol. 1967 May;190(1):35–53. doi: 10.1113/jphysiol.1967.sp008191. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Casati R., Lombardi F., Malliani A. Afferent sympathetic unmyelinated fibres with left ventricular endings in cats. J Physiol. 1979 Jul;292:135–148. doi: 10.1113/jphysiol.1979.sp012842. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Felder R. B., Thames M. D. Interaction between cardiac receptors and sinoaortic baroreceptors in the control of efferent cardiac sympathetic nerve activity during myocardial ischemia in dogs. Circ Res. 1979 Dec;45(6):728–736. doi: 10.1161/01.res.45.6.728. [DOI] [PubMed] [Google Scholar]
  13. Lombardi F., Della Bella P., Casati R., Malliani A. Effects of intracoronary administration of bradykinin on the impulse activity of afferent sympathetic unmyelinated fibers with left ventricular endings in the cat. Circ Res. 1981 Jan;48(1):69–75. doi: 10.1161/01.res.48.1.69. [DOI] [PubMed] [Google Scholar]
  14. Maksymowicz W., Szulczyk P. Properties of mechanoreceptor afferent fibres in left inferior cardiac nerve. Brain Res. 1983 Mar 7;262(2):209–215. doi: 10.1016/0006-8993(83)91010-7. [DOI] [PubMed] [Google Scholar]
  15. Malliani A., Recordati G., Schwartz P. J. Nervous activity of afferent cardiac sympathetic fibres with atrial and ventricular endings. J Physiol. 1973 Mar;229(2):457–469. doi: 10.1113/jphysiol.1973.sp010147. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. Peters S. R., Kostreva D. R., Armour J. A., Zuperku E. J., Igler F. O., Coon R. L., Kampine J. P. Cardiac, aortic, pericardial, and pulmonary receptors in the dog. Cardiology. 1980;65(2):85–100. doi: 10.1159/000170798. [DOI] [PubMed] [Google Scholar]
  17. Siegel J. M. Behavioral functions of the reticular formation. Brain Res. 1979 Jul;180(1):69–105. doi: 10.1016/0165-0173(79)90017-1. [DOI] [PMC free article] [PubMed] [Google Scholar]
  18. Sole M. J., Hussain M. N., Lixfeld W. Activation of brain catecholaminergic neurons by cardiac vagal afferents during acute myocardial ischemia in the rat. Circ Res. 1980 Aug;47(2):166–172. doi: 10.1161/01.res.47.2.166. [DOI] [PubMed] [Google Scholar]
  19. Sole M. J., Versteeg D. H., de Kloet E. R., Hussain N., Lixfeld W. The identification of specific serotonergic nuclei inhibited by cardiac vagal afferents during acute myocardial ischemia in the rat. Brain Res. 1983 Apr 11;265(1):55–61. doi: 10.1016/0006-8993(83)91333-1. [DOI] [PubMed] [Google Scholar]
  20. Thorén P. N. Activation of left ventricular receptors with nonmedullated vagal afferent fibers during occlusion of a coronary artery in the cat. Am J Cardiol. 1976 Jun;37(7):1046–1051. doi: 10.1016/0002-9149(76)90422-7. [DOI] [PubMed] [Google Scholar]
  21. Trevino D. L., Coulter J. D., Willis W. D. Location of cells of origin of spinothalamic tract in lumbar enlargement of the monkey. J Neurophysiol. 1973 Jul;36(4):750–761. doi: 10.1152/jn.1973.36.4.750. [DOI] [PubMed] [Google Scholar]
  22. Uchida U., Murao S. Afferent sympathetic nerve fibers originating in left atrial wall. Am J Physiol. 1974 Oct;227(4):753–758. doi: 10.1152/ajplegacy.1974.227.4.753. [DOI] [PubMed] [Google Scholar]
  23. Uchida Y. Afferent sympathetic nerve fibers with mechanoreceptors in the right heart. Am J Physiol. 1975 Jan;228(1):223–230. doi: 10.1152/ajplegacy.1975.228.1.223. [DOI] [PubMed] [Google Scholar]
  24. Uchida Y., Murao S. Excitation of afferent cardiac sympathetic nerve fibers during coronary occlusion. Am J Physiol. 1974 May;226(5):1094–1099. doi: 10.1152/ajplegacy.1974.226.5.1094. [DOI] [PubMed] [Google Scholar]
  25. Ueda H., Uchida Y., Kamisaka K. Distribution and responses of the cardiac sympathetic receptors to mechanically induced circulatory changes. Jpn Heart J. 1969 Jan;10(1):70–81. doi: 10.1536/ihj.10.70. [DOI] [PubMed] [Google Scholar]
  26. WHITE J. C. Cardiac pain: anatomic pathways and physiologic mechanisms. Circulation. 1957 Oct;16(4):644–655. doi: 10.1161/01.cir.16.4.644. [DOI] [PubMed] [Google Scholar]
  27. Weber R. N., Blair R. W., Foreman R. D. Effects of cardiac administration of bradykinin on thoracic spinal neurons in the cat. Exp Neurol. 1982 Dec;78(3):703–715. doi: 10.1016/0014-4886(82)90085-1. [DOI] [PubMed] [Google Scholar]

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