Skip to main content
PMC home page
The Journal of Physiology logoLink to The Journal of Physiology
. 1988 Dec;407:373–383. doi: 10.1113/jphysiol.1988.sp017421

The effect of thyroidectomy in the fetal sheep on lung liquid reabsorption induced by adrenaline or cyclic AMP.

P M Barker 1, M J Brown 1, C A Ramsden 1, L B Strang 1, D V Walters 1
PMCID: PMC1191209  PMID: 2855741

Abstract

1. In fetal sheep at 113-120 days' gestation, thyroidectomy was performed and tracheal, arterial and venous catheters inserted. Following a recovery period experiments were performed from 120-145 days to measure changes in lung liquid secretion or its absorption in response to I.V. adrenaline infusion or to introduction of dibuteryl cyclic AMP into lung liquid. The results were compared with those previously obtained in non-thyroidectomized fetuses. 2. Plasma levels of thyroid hormones in non-thyroidectomized fetuses confirmed the pattern found by previous workers. In thyroidectomized fetuses the levels of thyroxine (T4), tri-iodothyronine (T3) and reverse T3 (rT3) were very low except in one fetus which showed biochemical evidence of thyroid regeneration towards the end of gestation. 3. In thyroidectomized fetuses the normal response to adrenaline infusion (diminution of reversal of lung liquid secretion) was profoundly suppressed and very little gestational maturation in this response took place, except in the one fetus with evidence of thyroid regeneration in which a normal reabsorptive response developed in late gestation. 4. In thyroidectomized fetuses, the normal response to dibuteryl cyclic AMP was greatly reduced and its increase with gestation which normally parallels that seen during adrenaline infusion did not take place.

Full text

PDF
373

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Abbassi V., Merchant K., Abramson D. Postnatal triiodothyronine concentrations in healthy preterm infants and in infants with respiratory distress syndrome. Pediatr Res. 1977 Jul;11(7):802–804. doi: 10.1203/00006450-197707000-00004. [DOI] [PubMed] [Google Scholar]
  2. Brown M. J., Jenner D. A. Novel double-isotope technique for enzymatic assay of catecholamines, permitting high precision, sensitivity and plasma sample capacity. Clin Sci (Lond) 1981 Nov;61(5):591–598. doi: 10.1042/cs0610591. [DOI] [PubMed] [Google Scholar]
  3. Brown M. J., Olver R. E., Ramsden C. A., Strang L. B., Walters D. V. Effects of adrenaline and of spontaneous labour on the secretion and absorption of lung liquid in the fetal lamb. J Physiol. 1983 Nov;344:137–152. doi: 10.1113/jphysiol.1983.sp014929. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Cuestas R. A., Lindall A., Engel R. R. Low thyroid hormones and respiratory-distress syndrome of the newborn. Studies on cord blood. N Engl J Med. 1976 Aug 5;295(6):297–302. doi: 10.1056/NEJM197608052950601. [DOI] [PubMed] [Google Scholar]
  5. Da Prada M., Zürcher Simultaneous radioenzymatic determination of plasma and tissue adrenaline, noradrenaline and dopamine within the femtomole range. Life Sci. 1976 Oct 15;19(8):1161–1174. doi: 10.1016/0024-3205(76)90251-4. [DOI] [PubMed] [Google Scholar]
  6. Fernhoff P. M., Brown A. L., Elsas L. J. Congenital hypothyroidism: increased risk of neonatal morbidity results in delayed treatment. Lancet. 1987 Feb 28;1(8531):490–491. doi: 10.1016/s0140-6736(87)92098-8. [DOI] [PubMed] [Google Scholar]
  7. Giannopoulos G., Smith S. K. Hormonal regulation of beta-adrenergic receptors in fetal rabbit lung in organ culture. Life Sci. 1982 Aug 23;31(8):795–802. doi: 10.1016/0024-3205(82)90707-x. [DOI] [PubMed] [Google Scholar]
  8. Gindler E. M., King J. D. Rapid colorimetric determination of calcium in biologic fluids with methylthymol blue. Am J Clin Pathol. 1972 Oct;58(4):376–382. doi: 10.1093/ajcp/58.5.376. [DOI] [PubMed] [Google Scholar]
  9. Hopkins P. S., Thorburn G. D. The effects of foetal thyroidectomy on the development of the ovine foetus. J Endocrinol. 1972 Jul;54(1):55–66. doi: 10.1677/joe.0.0540055. [DOI] [PubMed] [Google Scholar]
  10. Mathur H., Brown B. L., Krane E. J., Thomas A. L., Nathanielsz P. W. Thyroid hormone relationships in the fetal and newborn lamb. Biol Neonate. 1980;37(3-4):138–141. doi: 10.1159/000241265. [DOI] [PubMed] [Google Scholar]
  11. Nathanielsz P. W., Comline R. S., Silver M., Thomas A. L. Thyroid function in the foetal lamb during the last third of gestation. J Endocrinol. 1973 Sep;58(3):535–546. doi: 10.1677/joe.0.0580535. [DOI] [PubMed] [Google Scholar]
  12. Nwosu U. C., Kaplan M. M., Utiger R. D., Delivoria-Papadoupoulos M. Plasma triiodothyronines in fetal sheep: effects of illness and thyroidectomy. Horm Metab Res. 1979 Oct;11(9):509–512. doi: 10.1055/s-0028-1092772. [DOI] [PubMed] [Google Scholar]
  13. Olver R. E., Ramsden C. A., Strang L. B., Walters D. V. The role of amiloride-blockable sodium transport in adrenaline-induced lung liquid reabsorption in the fetal lamb. J Physiol. 1986 Jul;376:321–340. doi: 10.1113/jphysiol.1986.sp016156. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Olver R. E., Strang L. B. Ion fluxes across the pulmonary epithelium and the secretion of lung liquid in the foetal lamb. J Physiol. 1974 Sep;241(2):327–357. doi: 10.1113/jphysiol.1974.sp010659. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. Redding R. A., Pereira C. Thyroid function in respiratory distress syndrome (RDS) of the newborn. Pediatrics. 1974 Oct;54(4):423–428. [PubMed] [Google Scholar]
  16. Sterling K. Thyroid hormone action at the cell level (second of two parts). N Engl J Med. 1979 Jan 25;300(4):173–177. doi: 10.1056/NEJM197901253000405. [DOI] [PubMed] [Google Scholar]
  17. Walters D. V., Olver R. E. The role of catecholamines in lung liquid absorption at birth. Pediatr Res. 1978 Mar;12(3):239–242. doi: 10.1203/00006450-197803000-00017. [DOI] [PubMed] [Google Scholar]

Articles from The Journal of Physiology are provided here courtesy of The Physiological Society

RESOURCES