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The Kaohsiung Journal of Medical Sciences logoLink to The Kaohsiung Journal of Medical Sciences
. 2009 Apr 11;25(1):25–28. doi: 10.1016/S1607-551X(09)70036-1

Diabetic Muscle Infarction in Association with Terlipressin Therapy: A Case Report

Yu‐Hung Chang 1,3, Feng‐Chieh Yen 3, Ming‐Chia Hsieh 2,3, Kun‐Der Lin 1,3, Shyi‐Jang Shin 2,3, Shih‐Chieh Hsin 3,
PMCID: PMC11917618  PMID: 19289314

Abstract

Diabetic muscle infarction (DMI) is a rare complication that often exists in long‐standing diabetic patients. Clinically, it presents with pain, swelling and sometimes a palpable mass, and is often misdiagnosed as soft tissue infection. The athogenesis of DMI is uncertain. We present the case of a type 2 diabetic patient with liver cirrhosis who was diagnosed with muscle infarction after being treated with terlipressin for gastrointestinal bleeding. This 45‐year‐old male complained of increasing pain in his right posterior thigh after treatment with terlipressin for 2 days. He was initially diagnosed with soft tissue infection, but he responded poorly to antibiotic treatment. Magnetic resonance imaging suggested acute muscle infarction. We performed a muscle biopsy and the pathologist reported that the muscle was necrotic. After 5 days of bed rest, the patient was able to walk and was discharged uneventfully.

Keywords: diabetic muscle infarction, terlipressin

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