Skip to main content
The Kaohsiung Journal of Medical Sciences logoLink to The Kaohsiung Journal of Medical Sciences
. 2009 Jul 13;22(6):297–300. doi: 10.1016/S1607-551X(09)70315-8

Subacute Thyroiditis Following Influenza Vaccine (Vaxigrip®) in A Young Female

Jeng‐Yueh Hsiao 1, Shih‐Chieh Hsin 1, Ming‐Chia Hsieh 1, Pi‐Jung Hsia 1, Shyi‐Jang Shin 1,
PMCID: PMC11917749  PMID: 16793568

Abstract

Subacute thyroiditis (SAT), also called de Quervain thyroiditis or granulomatous thyroiditis, is a self‐ limiting, possibly viral, and inflammatory thyroid disorder that is usually associated with thyroid pain and systemic symptoms. This report details a case of SAT possibly associated with influenza vaccine (Vaxigrip®) in a young female. The diagnosis, therapeutic management and outcome are discussed.

Keywords: subacute thyroiditis, de Quervain thyroiditis, influenza vaccine

Full Text

The Full Text of this article is available as a PDF (401.3 KB).

References

  • 1. Intenzo CM, Park CH, Kim SM, et al. Clinical laboratory and scintigraphic manifestation of subacute and chronic thyroiditis. Clin Nucl Med. 1993; 18: 302–306. [DOI] [PubMed] [Google Scholar]
  • 2. Singer PA. Thyroiditis: acute, subacute, and chronic. Med Clin North Am. 1991; 75: 61–77. [DOI] [PubMed] [Google Scholar]
  • 3. Volpe R. Subacute thyroiditis. Prog Clin Biol Res. 1981; 74: 115–134. [PubMed] [Google Scholar]
  • 4. Slatosky J, Shipton B, Wahba H. Thyroiditis: differential diagnosis and management. Am Fam Physician. 2000; 61: 1047–1052, 1054. [PubMed] [Google Scholar]
  • 5. Burke A, Marjorie T. Fever of unknown origin: subacute thyroiditis versus typhoid fever. Heart Lung. 2005; 34: 147–151. [DOI] [PubMed] [Google Scholar]
  • 6. Brouqui P, Raoult D. Conte‐Devolx B Coxsackie thyroiditis. Ann Intern Med. 1991; 114: 1063–1064. [DOI] [PubMed] [Google Scholar]
  • 7. Volpe R, Row VV, Ezrin C. Circulating viral and thyroid antibodies in subacute thyroiditis. J Clin Endocrinol Metab. 1967; 27: 1275–1284. [DOI] [PubMed] [Google Scholar]
  • 8. Sato M. Virus‐like particles in the follicular epithelium of the thyroid from a patient with subacute thyroiditis. Acta Pathol Jpn. 1975; 25: 499–501. [PubMed] [Google Scholar]
  • 9. Pearce EN, Farwell AP, Braverman LE. Thyroiditis. N Engl J Med. 2003; 348: 2646–2655. [DOI] [PubMed] [Google Scholar]
  • 10. Greene JN. Subacute thyroiditis. Am J Med. 1971; 51: 97–108. [DOI] [PubMed] [Google Scholar]
  • 11. Pearce EN, Martino E, Bogazzi F. The prevalence of elevated serum C‐reactive protein levels in inflammatory and noninflammatory thyroid disease. Thyroid. 2003; 13: 643–648. [DOI] [PubMed] [Google Scholar]
  • 12. Hiromatsu Y, Ishibashi M, Miyake I. Color Doppler ultrasonography in patients with subacute thyroiditis. Thyroid. 1999; 9: 1189–1193. [DOI] [PubMed] [Google Scholar]
  • 13. Mizukoshi T, Noguchi S, Murakami T, et al. Evaluation of recurrence in 36 subacute thyroiditis patients managed with prednisolone. Intern Med. 2001; 40: 292–295. [DOI] [PubMed] [Google Scholar]
  • 14. Tauveron I, Thieblot P, Marcheix JC. Recurrence after 12 years of de Quervain‐Crile subacute thyroiditis. Rev Med Interne. 1991; 12: 396 [In French]. [DOI] [PubMed] [Google Scholar]
  • 15. Bauman A, Friedman A. Recurrence subacute thyroiditis: a report of three cases. NY State J Med. 1983; 83: 987–988. [PubMed] [Google Scholar]
  • 16. Iitaka M, Momotani N, Ishii J, et al. Incidence of subacute thyroiditis recurrences after a prolonged latency: 24‐year survey. J Clin Endocrinol Metab. 1996; 81: 466–469. [DOI] [PubMed] [Google Scholar]
  • 17. Yamamoto M, Saito S, Sakurada T, et al. Recurrence of subacute thyroiditis over 10 years after the first attack in three cases. Endocrinol Jpn. 1988; 35: 833–839. [DOI] [PubMed] [Google Scholar]
  • 18. Odelin MF, Pozzetto B. Tolerance of influenza vaccination in the aged and the nursing staff in a geriatric hospital. Therapie. 1994; 49: 447–450. [PubMed] [Google Scholar]
  • 19. Proctor GD. “Vaxigrip” influenza vaccine. Med J Aust. 1984; 141: 136. [DOI] [PubMed] [Google Scholar]
  • 20. Vahab F. Clinical features and outcome of subacute thyroiditis in an incidence cohort: Olmsted County, Minnesota, Study. J Clin Endocrinol Metab. 2003; 188: 2100–2105. [DOI] [PubMed] [Google Scholar]
  • 21. Spila‐Alegiani S, Salmaso S, Rota MC, et al. Reactogenicity in the elderly of nine commercial influenza vaccines: results from the Italian SVEVA study. Study for the evaluation of adverse events of influenza vaccination. Vaccine. 1999; 17 (15‐16): 1898–1904. [DOI] [PubMed] [Google Scholar]
  • 22. Delore V, Salamand C, Marsh G, Arnoux S, Pepin S, Saliou P. Long‐term clinical trial safety experience with the inactivated split influenza vaccine, Vaxigrip. Vaccine. 2006; 24: 1586–1592. [DOI] [PubMed] [Google Scholar]

Articles from The Kaohsiung Journal of Medical Sciences are provided here courtesy of Kaohsiung Medical University and John Wiley & Sons Australia, Ltd

RESOURCES