Skip to main content
NCBI home page
The Journal of Physiology logoLink to The Journal of Physiology
. 1985 Nov;368:501–511. doi: 10.1113/jphysiol.1985.sp015872

Evidence for the involvement of the organum vasculosum laminae terminalis in the febrile response of rabbits and rats.

J T Stitt
PMCID: PMC1192611  PMID: 4078749

Abstract

Control febrile responses to intravenous injections of endogenous pyrogen were determined in groups of rabbits and rats, exposed to their respective thermoneutral ambient temperatures. Discrete electrolytic lesions were placed within the confines of the organum vasculosum laminae terminalis (o.v.l.t.) of each species. The fever responses of the animals were remeasured 3 days later, and in every case there was a marked enhancement of the fevers produced, using the same doses of endogenous pyrogen that were used earlier. Similar lesions that were placed unilaterally within the preoptic anterior hypothalamic area in groups of control animals, were not effective in enhancing the febrile responses of these animals. The course of this lesion-induced fever enhancement in rabbits was studied during the succeeding 3 week period, when it was found to return gradually towards the control levels. It is postulated that the o.v.l.t. is involved in some manner in the process whereby circulating pyrogen is translated into a febrile stimulus. Lesions posited within this region are thought to either increase the amount of pyrogen entering the o.v.l.t., or to increase the sensitivity of pyrogen receptor sites within the o.v.l.t.

Full text

PDF
501

Images in this article

510-2Plate 1
on p.510-2
510-1Plate 1 (cont.)
on p.510-1

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. BRIZZEE K. R. A comparison of cell structure in the area postrema, supraoptic crest, and intercolumnar tubercle with notes on the neurohypophysis and pineal body in the cat. J Comp Neurol. 1954 Jun;100(3):699–715. doi: 10.1002/cne.901000310. [DOI] [PubMed] [Google Scholar]
  2. Blatteis C. M., Bealer S. L., Hunter W. S., Llanos-Q J., Ahokas R. A., Mashburn T. A., Jr Suppression of fever after lesions of the anteroventral third ventricle in guinea pigs. Brain Res Bull. 1983 Nov;11(5):519–526. doi: 10.1016/0361-9230(83)90124-7. [DOI] [PubMed] [Google Scholar]
  3. Camacho A., Phillips M. I. Horseradish peroxidase study in rat of the neural connections of the organum vasculosum of the lamina terminalis. Neurosci Lett. 1981 Sep 25;25(3):201–204. doi: 10.1016/0304-3940(81)90391-8. [DOI] [PubMed] [Google Scholar]
  4. Cooper K. E., Cranston W. I., Honour A. J. Observations on the site & mode of action of pyrogens in the rabbit brain. J Physiol. 1967 Jul;191(2):325–337. doi: 10.1113/jphysiol.1967.sp008253. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Dinarello C. A., Bernheim H. A. Ability of human leukocytic pyrogen to stimulate brain prostaglandin synthesis in vitro. J Neurochem. 1981 Sep;37(3):702–708. doi: 10.1111/j.1471-4159.1982.tb12544.x. [DOI] [PubMed] [Google Scholar]
  6. Dinarello C. A. Interleukin-1. Rev Infect Dis. 1984 Jan-Feb;6(1):51–95. doi: 10.1093/clinids/6.1.51. [DOI] [PubMed] [Google Scholar]
  7. Hellon R., Townsend Y. Mechanisms of fever. Pharmacol Ther. 1982;19(2):211–244. doi: 10.1016/0163-7258(82)90063-8. [DOI] [PubMed] [Google Scholar]
  8. Jackson D. L. A hypothalamic region responsive to localized injection of pyrogens. J Neurophysiol. 1967 May;30(3):586–602. doi: 10.1152/jn.1967.30.3.586. [DOI] [PubMed] [Google Scholar]
  9. KLATZO I., PIRAUX A., LASKOWSKI E. J. The relationship between edema, blood-brain-barrier and tissue elements in a local brain injury. J Neuropathol Exp Neurol. 1958 Oct;17(4):548–564. doi: 10.1097/00005072-195810000-00002. [DOI] [PubMed] [Google Scholar]
  10. SAWYER C. H., EVERETT J. W., GREEN J. D. The rabbit diencephalon in stereotaxic coordinates. J Comp Neurol. 1954 Dec;101(3):801–824. doi: 10.1002/cne.901010307. [DOI] [PubMed] [Google Scholar]
  11. Stitt J. T., Bernheim H. A. Differences in endogenous pyrogen fevers induced by iv and icv routes in rabbits. J Appl Physiol (1985) 1985 Aug;59(2):342–347. doi: 10.1152/jappl.1985.59.2.342. [DOI] [PubMed] [Google Scholar]
  12. Stitt J. T., Hardy J. D., Stolwijk J. A. PGE1 fever: its effect on thermoregulation at different low ambient temperatures. Am J Physiol. 1974 Sep;227(3):622–629. doi: 10.1152/ajplegacy.1974.227.3.622. [DOI] [PubMed] [Google Scholar]
  13. Stitt J. T. The regulation of respiratory evaporative heat loss in the rabbit. J Physiol. 1976 Jun;258(1):157–171. doi: 10.1113/jphysiol.1976.sp011412. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. WISLOCKI G. B., LEDUC E. H. Vital staining of the hematoencephalic barrier by silver nitrate and trypan blue, and cytological comparisons of the neurohypophysis, pineal body, area postrema, intercolumnar tubercle and supraoptic crest. J Comp Neurol. 1952 Jun;96(3):371–413. doi: 10.1002/cne.900960302. [DOI] [PubMed] [Google Scholar]
  15. Weindl A., Joynt R. J. Ultrastructure of the ventricular walls. Three-dimensional study of regional specialization. Arch Neurol. 1972 May;26(5):420–427. doi: 10.1001/archneur.1972.00490110054005. [DOI] [PubMed] [Google Scholar]
  16. Weindl A., Schwink A., Wetzstein R. Der Feinbau des GefäBorgans der Lamina terminalis beim Kaninchen. Z Zellforsch Mikrosk Anat. 1967;79(1):1–48. [PubMed] [Google Scholar]
  17. Weindl A. Zur Morphologie und Histochemie von Subfornicalorgan, Organum vasculosum laminae terminalis und Area postrema bei Kaninchen und Ratte. Z Zellforsch Mikrosk Anat. 1965 Sep 17;67(6):740–775. [PubMed] [Google Scholar]

Articles from The Journal of Physiology are provided here courtesy of The Physiological Society

RESOURCES