Skip to main content
NCBI home page
The Journal of Physiology logoLink to The Journal of Physiology
. 1986 Feb;371:29–43. doi: 10.1113/jphysiol.1986.sp015960

The release of histamine by parasympathetic stimulation in guinea-pig auricle and rat ileum.

T Bani-Sacchi, M Barattini, S Bianchi, P Blandina, S Brunelleschi, R Fantozzi, P F Mannaioni, E Masini
PMCID: PMC1192709  PMID: 2422351

Abstract

Two preparations, a segment of rat ileum and the vagally innerved guinea-pig auricles, have been used in an analysis of the responses to vagal or to electrical field stimulation. The responses to parasympathetic stimulation were depressed by atropine and by tetrodotoxin, and potentiated by eserine. Supramaximal stimulation (10-20 Hz) resulted in increased release of acetylcholine and histamine, both in rat ileum and guinea-pig auricles. The release of histamine after parasympathetic stimulation did not exhibit tachyphylaxis, and it was not reproduced by non-parasympathetic stimuli. In both preparations, atropine produced a significant, dose-related reduction of histamine measured in the bath fluid after stimulation, while eserine increased histamine output. A significant diminution of mast cell granules metachromasia was observed in guinea-pig auricles and in rat intestine after parasympathetic stimulation. The possibility is discussed that acetylcholine released by parasympathetic stimulation would in turn evoke the secretion of histamine from tissue mast cells.

Full text

PDF
29

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Bienenstock J., Befus A. D., Pearce F., Denburg J., Goodacre R. Mast cell heterogeneity: derivation and function, with emphasis on the intestine. J Allergy Clin Immunol. 1982 Dec;70(6):407–412. doi: 10.1016/0091-6749(82)90001-x. [DOI] [PubMed] [Google Scholar]
  2. Blandina P., Barattini M., Fantozzi R., Masini E., Brunelleschi S., Mannaioni P. F. Mediator release from isolated rat ileum in response to field stimulation. Agents Actions. 1984 Apr;14(3-4):405–409. doi: 10.1007/BF01973838. [DOI] [PubMed] [Google Scholar]
  3. Blandina P., Barattini M., Fantozzi R., Masini E., Mannaioni P. F. Histamine release by vagal stimulation. Agents Actions. 1983 Apr;13(2-3):179–182. doi: 10.1007/BF01967326. [DOI] [PubMed] [Google Scholar]
  4. Blandina P., Fantozzi R., Mannaioni P. F., Masini E. Characteristics of histamine release evoked by acetylcholine in isolated rat mast cells. J Physiol. 1980 Apr;301:281–293. doi: 10.1113/jphysiol.1980.sp013205. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Brugal G., Garbay C., Giroud F., Adelh D. A double scanning microphotometer for image analysis: hardware, software and biomedical applications. J Histochem Cytochem. 1979 Jan;27(1):144–152. doi: 10.1177/27.1.374569. [DOI] [PubMed] [Google Scholar]
  6. Cowie A. L., Kosterlitz H. W., Waterfield A. A. Factors influencing the release of acetylcholine from the myenteric plexus of the ileum of the guinea-pig and rabbit. Br J Pharmacol. 1978 Dec;64(4):565–580. doi: 10.1111/j.1476-5381.1978.tb17319.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Dieterich H. A., Löffelholz K., Pompetzki H. Acetylcholine overflow from isolated perfused hearts of various species in the absence of cholinesterase inhibition. Naunyn Schmiedebergs Arch Pharmacol. 1977 Jan;296(2):149–152. doi: 10.1007/BF00508467. [DOI] [PubMed] [Google Scholar]
  8. Fantozzi R., Masini E., Blandina P., Mannaioni P. F., Bani-Sacchi T. Release of histamine from rat mast cells by acetylcholine. Nature. 1978 Jun 8;273(5662):473–474. doi: 10.1038/273473a0. [DOI] [PubMed] [Google Scholar]
  9. Fantozzi R., Masini E., Blandina P., Mannaioni P. F. Cholinergic histamine release: evidence of muscarinic receptors in rat mast cells [proceedings]. Agents Actions. 1979 Apr;9(1):57–58. doi: 10.1007/BF02024110. [DOI] [PubMed] [Google Scholar]
  10. Fantozzi R., Moroni F., Masini E., Blandina P., Mannaioni P. F. Modulation of the spontaneous histamine release by adrenergic and cholinergic drugs. Agents Actions. 1978 Jun;8(4):347–358. doi: 10.1007/BF01968614. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Foreman J. C. The pharmacological control of immediate hypersensitivity. Annu Rev Pharmacol Toxicol. 1981;21:63–81. doi: 10.1146/annurev.pa.21.040181.000431. [DOI] [PubMed] [Google Scholar]
  12. Foreman J., Jordan C. Histamine release and vascular changes induced by neuropeptides. Agents Actions. 1983 Apr;13(2-3):105–116. doi: 10.1007/BF01967311. [DOI] [PubMed] [Google Scholar]
  13. Giotti A., Guidotti A., Mannaioni P. F., Zilletti L. The influences of andrenotropic drugs and noradrenaline on the histamine release in cardiac anaphylaxis in vitro. J Physiol. 1966 Jun;184(4):924–941. doi: 10.1113/jphysiol.1966.sp007957. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Guidotti A., Zilletti L., Giotti A. Correlation between mast-cell population and histamine content of guinea-pig heart. Sperimentale. 1967 Mar-Apr;117(2):113–123. [PubMed] [Google Scholar]
  15. Heine H., Förster F. J. Relationships between mast cells and preterminal nerve fibers. Z Mikrosk Anat Forsch. 1975;89(5):934–937. [PubMed] [Google Scholar]
  16. Hutchinson M., Kosterlitz H. W., Gilbert J. C. Effects of physostigmine and electrical stimulation on the acetylcholine content of the guinea-pig ileum. Eur J Pharmacol. 1976 Oct;39(2):221–235. doi: 10.1016/0014-2999(76)90130-8. [DOI] [PubMed] [Google Scholar]
  17. Kazimierczak W., Diamant B. Mechanisms of histamine release in anaphylactic and anaphylactoid reactions. Prog Allergy. 1978;24:295–365. [PubMed] [Google Scholar]
  18. Kiernan J. A. Effects of known and suspected neurotransmitter substances and of some nucleotides on isolated mast cells. Experientia. 1972 Jun 15;28(6):653–655. doi: 10.1007/BF01944958. [DOI] [PubMed] [Google Scholar]
  19. Lorenz W., Reimann H. J., Barth H., Kusche J., Meyer R., Doenicke A., Hutzel M. A sensitive and specific method for the determination of histomine in human whole blood and plasma. Hoppe Seylers Z Physiol Chem. 1972 Jun;353(6):911–920. doi: 10.1515/bchm2.1972.353.1.911. [DOI] [PubMed] [Google Scholar]
  20. MOTA I. Effect of antigen and octylamine on mast cells and histamine content of sensitized guinea-pig tissues. J Physiol. 1959 Oct;147:425–436. doi: 10.1113/jphysiol.1959.sp006253. [DOI] [PMC free article] [PubMed] [Google Scholar]
  21. Masini E., Blandina P., Fantozzi R., Brunelleschi S., Mannaioni P. F. Correlation between cholinergic histamine release and quinuclidinyl-benzilate ([3H]-QNB) binding in mast cell membranes. Agents Actions. 1981 Apr;11(1-2):55–59. doi: 10.1007/BF01991456. [DOI] [PubMed] [Google Scholar]
  22. Masini E., Fantozzi R., Blandina P., Brunelleschi S., Mannaioni P. F. Muscarinic cholinergic receptor binding in rat mast cells. Agents Actions. 1983 Jun;13(4):327–332. doi: 10.1007/BF01971484. [DOI] [PubMed] [Google Scholar]
  23. Newson B., Dahlström A., Enerbäck L., Ahlman H. Suggestive evidence for a direct innervation of mucosal mast cells. Neuroscience. 1983 Oct;10(2):565–570. doi: 10.1016/0306-4522(83)90153-7. [DOI] [PubMed] [Google Scholar]
  24. Ploem J. S., Verwoerd N., Bonnet J., Koper G. An automated microscope for quantitative cytology combining television image analysis and stage scanning microphotometry. J Histochem Cytochem. 1979 Jan;27(1):136–143. doi: 10.1177/27.1.374568. [DOI] [PubMed] [Google Scholar]
  25. SHORE P. A., BURKHALTER A., COHN V. H., Jr A method for the fluorometric assay of histamine in tissues. J Pharmacol Exp Ther. 1959 Nov;127:182–186. [PubMed] [Google Scholar]
  26. Sahota T. S., Ibaraki A., Heywood F. G., Farris S. H., Van der Wereld A. M. Image enhancement for light microscopy. Stain Technol. 1981 Nov;56(6):361–366. doi: 10.3109/10520298109067344. [DOI] [PubMed] [Google Scholar]
  27. Schild H. O. A method of conducting a biological assay on a preparation giving repeated graded responses illustrated by the estimation of histamine. J Physiol. 1942 Jun 2;101(1):115–130. doi: 10.1113/jphysiol.1942.sp003970. [DOI] [PMC free article] [PubMed] [Google Scholar]
  28. Stach W., Weiss R., Radke R. Licht- und elektronenmikroskopische Unitersuchungen über de Nervengeflechte der Magenschleimhaut und deren Beziehungen zu Beleg- und Mastzellen. Dtsch Z Verdau Stoffwechselkr. 1975;35(5):205–218. [PubMed] [Google Scholar]
  29. Van der Ploeg M., Van den Broek K., Smeulders A. W., Vossepoel A. M., Van Duijn P. HIDACSYS: computer programs for interactive scanning cytophotometry. Histochemistry. 1977 Dec 28;54(4):273–288. doi: 10.1007/BF00508271. [DOI] [PubMed] [Google Scholar]
  30. Wiesner-Menzel L., Schulz B., Vakilzadeh F., Czarnetzki B. M. Electron microscopical evidence for a direct contact between nerve fibres and mast cells. Acta Derm Venereol. 1981;61(6):465–469. doi: 10.2340/0001555561465469. [DOI] [PubMed] [Google Scholar]
  31. Yamatodani A., Maeyama K., Watanabe T., Wada H., Kitamura Y. Tissue distribution of histamine in a mutant mouse deficient in mast cells: clear evidence for the presence of non-mast-cell histamine. Biochem Pharmacol. 1982 Feb 1;31(3):305–309. doi: 10.1016/0006-2952(82)90175-7. [DOI] [PubMed] [Google Scholar]

Articles from The Journal of Physiology are provided here courtesy of The Physiological Society

RESOURCES