Correction to “Amoxicillin oral provocation challenge in a primary care clinic: a descriptive analysis”

An error occurred in an article published Apr. 16, 2021.¹

In the Results and Interpretation sections, the authors stated that all 3 of the patients who had a positive reaction to amoxicillin oral provocation challenge had a previous history of immediate reaction, when in fact they did not. The 3 positive reactions were described correctly in narrative form in an appendix, and the discrepancy was noted and brought to the authors’ attention.

In the Results section, fourth paragraph, the text,

Reactions to OPC were uncommon (3/99, 3.0%, 95% CI 3%–9%). The patients who had an immediate reaction were pediatric and had a World Allergy Organization reaction grade of 1. All 3 patients who reacted had a personal history of immediate reaction, out of the 9 patients with a similar history (reaction rate of 33%).

should have read,

Reactions to OPC were uncommon (3/99, 3.0%, 95% CI 3%–9%). The 3 patients who had an immediate reaction were pediatric and had a World Allergy Organization reaction grade of 1, but did not have a history of immediate reaction. No patients with a history of immediate reaction (n = 9) had an immediate reaction to OPC.

In the Interpretation section, fourth paragraph, the text,

There were 3 immediate allergic reactions among those 9 patients with a history of immediate reaction (reaction rate of 33%). This represents a 10-fold increase over the reaction rate among all patients in our study who underwent OPC. Although history of immediate reaction is a risk factor for allergic reaction, most patients with a history of immediate reaction did not react to OPC, and were de-labelled as allergic to penicillin and related drugs.

should have read,

The overall reaction rate in our study was 3.0%. None of the 3 patients in our study who had an immediate reaction after OPC had a history of immediate reaction. Although a history of immediate reaction is a risk factor for allergic reaction, no patients with a history of immediate reaction reacted to OPC in our study, and as such, were all de-labelled as allergic to penicillin and related drugs.

This error has been corrected at cmajopen.ca.