Skip to main content
NCBI home page
The Journal of Physiology logoLink to The Journal of Physiology
. 1985 May;362:261–271. doi: 10.1113/jphysiol.1985.sp015675

Urinary sodium excretion and the renin-aldosterone system in new-born calves.

A Safwate
PMCID: PMC1192894  PMID: 3894622

Abstract

Urinary Na+ and K+ excretion, plasma aldosterone levels (PAL) and plasma renin activity (PRA) were measured in three groups of four 3-day-old calves infused with aldosterone, ethacrynic acid and hydrochlorothiazide or with vehicle. Aldosterone infusion (16.7 micrograms/kg body wt. given by rapid injection, followed by the infusion of 33.3 micrograms/kg body wt. during 6 h) decreased urinary Na+ concentration and excretion during the 6 h period of infusion. This effect disappeared during the following 18 h. Ethacrynic acid (2 mg/kg body wt. by rapid injection, followed by the infusion of 1.5 mg/kg body wt..h during 6 h) and hydrochlorothiazide (8 mg/kg body wt. by rapid injection, followed by the infusion of 6 mg/kg body wt..h during 6 h) increased urinary volume and urinary excretion of Na+, but decreased urinary K+ concentration without affecting urinary K+ excretion during the 6 h period of infusion. During the same time, the plasma Na+ concentration decreased, PRA increased rapidly and was followed by a significant rise in PAL. These results demonstrate that in very young healthy calves, the renal tubules are able to respond to aldosterone. The renin-aldosterone system is also operative in these animals since it responds to Na+ depletion induced by the combination of diuretics and inhibitors of tubular Na+ reabsorption.

Full text

PDF
261

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. AUGUST J. T., NELSON D. H., THORN G. W. Response of normal subjects to large amounts of aldosterone. J Clin Invest. 1958 Nov;37(11):1549–1555. doi: 10.1172/JCI103747. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Bayard F., Beitins I. Z., Kowarski A., Migeon C. J. Measurement of plasma aldosterone by radioimmunoassay. J Clin Endocrinol Metab. 1970 Jul;31(1):1–6. doi: 10.1210/jcem-31-1-1. [DOI] [PubMed] [Google Scholar]
  3. CANNON P. J., AMES R. P., LARAGH J. H. METHYLENEBUTYRYL PHENOXYACETIC ACID: NOVEL AND POTENT NATRIURETIC AND DIURETIC AGENT. JAMA. 1963 Sep 14;185:854–863. doi: 10.1001/jama.1963.03060110058019. [DOI] [PubMed] [Google Scholar]
  4. Cabello G. Plasma cortisol and aldosterone levels in healthy and diarrhoeic calves. Br Vet J. 1980 Mar-Apr;136(2):160–167. doi: 10.1016/s0007-1935(17)32339-4. [DOI] [PubMed] [Google Scholar]
  5. Cremaschi D., Ferguson D. R., Hénin S., James P. S., Meyer G., Smith M. W. Post-natal development of amiloride sensitive sodium transport in pig distal colon. J Physiol. 1979 Jul;292:481–494. doi: 10.1113/jphysiol.1979.sp012866. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Dillon M. J., Rajani K. B., Shah V., Ryness J. M., Milner R. D. Renin and aldosterone response in human newborns to acute change in blood volume. Arch Dis Child. 1978 Jun;53(6):461–467. doi: 10.1136/adc.53.6.461. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Fayet J. C. Plasma and faecal osmolality, water kinetics and body fluid compartments in neonatal calves with diarrhoea. Br Vet J. 1971 Jan;127(1):37–44. doi: 10.1016/s0007-1935(17)37787-4. [DOI] [PubMed] [Google Scholar]
  8. Ferguson D. R., James P. S., Paterson J. Y., Saunders J. C., Smith M. W. Aldosterone induced changes in colonic sodium transport occurring naturally during development in the neonatal pig. J Physiol. 1979 Jul;292:495–504. doi: 10.1113/jphysiol.1979.sp012867. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Fisher E. W., De la Fuente G. H. Water and electrolyte studies in newborn calves with particular reference to the effects of diarrhoea. Res Vet Sci. 1972 Jul;13(4):315–322. [PubMed] [Google Scholar]
  10. Giry J., Delost P. Changes in the concentrations of aldosterone in the plasma and adrenal glands of the foetus, the newborn and the pregnant guinea-pig during the perinatal period. Acta Endocrinol (Copenh) 1977 Jan;84(1):133–141. doi: 10.1530/acta.0.0840133. [DOI] [PubMed] [Google Scholar]
  11. Goldberg M. Ethacrynic acid: site and mode of action. Ann N Y Acad Sci. 1966 Nov 22;139(2):443–452. doi: 10.1111/j.1749-6632.1966.tb41218.x. [DOI] [PubMed] [Google Scholar]
  12. Granger P., Rojo-Ortega J. M., Casado Pérez S., Boucher R., Genest J. The renin-angiotensin system in newborn dogs. Can J Physiol Pharmacol. 1971 Feb;49(2):134–138. doi: 10.1139/y71-019. [DOI] [PubMed] [Google Scholar]
  13. Haber E., Koerner T., Page L. B., Kliman B., Purnode A. Application of a radioimmunoassay for angiotensin I to the physiologic measurements of plasma renin activity in normal human subjects. J Clin Endocrinol Metab. 1969 Oct;29(10):1349–1355. doi: 10.1210/jcem-29-10-1349. [DOI] [PubMed] [Google Scholar]
  14. Horster M., Lückhoff A. Aldosterone on sodium transport of rat distal colon in long-term adrenalectomy during acute and chronic substitution. J Physiol. 1983 Jul;340:503–511. doi: 10.1113/jphysiol.1983.sp014776. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. Hurley J. K., Kirkpatrick S. E., Pitlick P. T., Friedman W. F., Mendoza S. A. Renal responses of the fetal lamb to fetal or maternal volume expansion. Circ Res. 1977 Jun;40(6):557–560. doi: 10.1161/01.res.40.6.557. [DOI] [PubMed] [Google Scholar]
  16. Iwamoto H. S., Rudolph A. M. Role of renin-angiotensin system in response to hemorrhage in fetal sheep. Am J Physiol. 1981 Jun;240(6):H848–H854. doi: 10.1152/ajpheart.1981.240.6.H848. [DOI] [PubMed] [Google Scholar]
  17. John E. G., Zeis P. M., Samayoa C., Chan L., Wojdula L., Aschinberg L. C. Renin - aldosterone system response to chronic salt loading and volume contraction in puppies. Int J Pediatr Nephrol. 1981 Mar;2(1):9–15. [PubMed] [Google Scholar]
  18. KESSLER R. H., HIERHOLZER K., GURD R. S., PITTS R. F. Localization of action of chlorothiazide in the nephron of the dog. Am J Physiol. 1959 Jun;196(6):1346–1351. doi: 10.1152/ajplegacy.1959.196.6.1346. [DOI] [PubMed] [Google Scholar]
  19. Kleinman L. I. Renal sodium reabsorption during saline loading and distal blockade in newborn dogs. Am J Physiol. 1975 May;228(5):1403–1408. doi: 10.1152/ajplegacy.1975.228.5.1403. [DOI] [PubMed] [Google Scholar]
  20. Kleinman L. I., Reuter J. H. Renal response of the new-born dog to a saline load: the role of intrarenal blood flow distribution. J Physiol. 1974 Jun;239(2):225–236. doi: 10.1113/jphysiol.1974.sp010565. [DOI] [PMC free article] [PubMed] [Google Scholar]
  21. Kumar S., Singh S. P. Muzzle secretion electrolytes as a possible indicator of sodium status in buffalo (Bubalus bubalis) calves: effects of sodium depletion and aldosterone administration. Aust J Biol Sci. 1981;34(5-6):561–568. doi: 10.1071/bi9810561. [DOI] [PubMed] [Google Scholar]
  22. Lingwood B., Hardy K. J., Coghlan J. P., Wintour E. M. Effect of aldosterone on urine composition in the chronically cannulated ovine foetus. J Endocrinol. 1978 Mar;76(3):553–554. doi: 10.1677/joe.0.0760553. [DOI] [PubMed] [Google Scholar]
  23. Loggie J. M., Kleinman L. I., Van Maanen E. F. Renal function and diuretic therapy in infants and children. Part I. J Pediatr. 1975 Apr;86(4):485–496. doi: 10.1016/s0022-3476(75)80136-3. [DOI] [PubMed] [Google Scholar]
  24. Lopez G. A., Phillips R. W., Lewis L. D. Plasma corticoid changes during diarrhea in neonatal calves. Am J Vet Res. 1975 Aug;36(08):1245–1247. [PubMed] [Google Scholar]
  25. Safwate A., Davicco M. J., Barlet J. P., Delost P. Plasma sodium, potassium and aldosterone levels in newborn calves. J Physiol (Paris) 1980;76(8):906–907. [PubMed] [Google Scholar]
  26. Safwate A., Davicco M. J., Barlet J. P., Delost P. Sodium and potassium balances and plasma aldosterone levels in newborn calves. Reprod Nutr Dev. 1982;22(4):689–696. doi: 10.1051/rnd:19820510. [DOI] [PubMed] [Google Scholar]
  27. Safwate A., Davicco M. J., Barlet J. P., Delost P. Sodium and potassium in blood and milk and plasma aldosterone levels in high-yield dairy cows. Reprod Nutr Dev. 1981;21(4):601–610. doi: 10.1051/rnd:19810412. [DOI] [PubMed] [Google Scholar]
  28. Siegel S. R., Fisher D. A. Ontogeny of the renin-angiotensin-aldosterone system in the fetal and newborn lamb. Pediatr Res. 1980 Feb;14(2):99–102. doi: 10.1203/00006450-198002000-00006. [DOI] [PubMed] [Google Scholar]
  29. Siegel S. R., Fisher D. A. The renin-angiotensin-aldosterone system in the newborn lamb: response to furosemide. Pediatr Res. 1977 Jul;11(7):837–839. doi: 10.1203/00006450-197707000-00012. [DOI] [PubMed] [Google Scholar]
  30. Thompson B. D., Edmonds C. J. Comparison of effects of prolonged aldosterone administration on rat colon and renal electrolyte excretion. J Endocrinol. 1971 May;50(1):163–169. doi: 10.1677/joe.0.0500163. [DOI] [PubMed] [Google Scholar]
  31. Trimper C. E., Lumbers E. R. The renin-angiotensin system in foetal lambs. Pflugers Arch. 1972;336(1):1–10. doi: 10.1007/BF00589136. [DOI] [PubMed] [Google Scholar]

Articles from The Journal of Physiology are provided here courtesy of The Physiological Society

RESOURCES