Abstract
A method of selectively blocking the larger nerve fibres in the optic nerve of the cat is described. The optic nerve is compressed between a small balloon and the inside of a small metal cylinder. The block is monitored by stimulating and recording on opposite sides of the blocked region. The t1 (Y) response can be eliminated usually with some loss of the t2 (X) response. Stimulation of the blocked optic nerve initially excites certain cells (r2 or X) in the dorsal lateral geniculate nucleus (d.l.g.n.) but this is followed by an inhibition of both r1 (Y) and r2 (X) cells. This inhibition is similar in time course to that produced by stimulation of t1 fibres, suggesting that the effect may be mediated via a similar mechanism. The effect is present in a preparation in which all t1 fibres have degenerated, removing the possibility that it might have been due to inadvertent stimulation of t1 fibres. Experiments on a small number of r2 (X) d.l.g.n. cells have confirmed the inhibitory effect of stimulation of the smaller optic nerve fibres on X cells.
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- Ahlsén G., Lindström S., Sybirska E. Subcortical axon collaterals of principal cells in the lateral geniculate body of the cat. Brain Res. 1978 Nov 3;156(1):106–109. doi: 10.1016/0006-8993(78)90084-7. [DOI] [PubMed] [Google Scholar]
- BISHOP P. O., DAVIS R. The recovery of responsiveness of the sensory synapses in the lateral geniculate nucleus. J Physiol. 1960 Jan;150:214–238. doi: 10.1113/jphysiol.1960.sp006383. [DOI] [PMC free article] [PubMed] [Google Scholar]
- BISHOP P. O., JEREMY D., LANCE J. W. The optic nerve; properties of a central tract. J Physiol. 1953 Aug;121(2):415–432. doi: 10.1113/jphysiol.1953.sp004955. [DOI] [PMC free article] [PubMed] [Google Scholar]
- BISHOP P. O., McLEOD J. G. Nature of potentials associated with synaptic transmission in lateral geniculate of cat. J Neurophysiol. 1954 Jul;17(4):387–414. doi: 10.1152/jn.1954.17.4.387. [DOI] [PubMed] [Google Scholar]
- Bishop G. H., Clare M. H., Landau W. M. Further analysis of fiber groups in the optic tract of the cat. Exp Neurol. 1969 Jul;24(3):386–399. doi: 10.1016/0014-4886(69)90144-7. [DOI] [PubMed] [Google Scholar]
- Cleland B. G., Dubin M. W., Levick W. R. Sustained and transient neurones in the cat's retina and lateral geniculate nucleus. J Physiol. 1971 Sep;217(2):473–496. doi: 10.1113/jphysiol.1971.sp009581. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Cleland B. G., Lee B. B., Vidyasagar T. R. Response of neurons in the cat's lateral geniculate nucleus to moving bars of different length. J Neurosci. 1983 Jan;3(1):108–116. doi: 10.1523/JNEUROSCI.03-01-00108.1983. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Coenen A. M., Gerrits H. J., Vendrik A. J. Analysis of the response characteristics of optic tract and geniculate units and their mutual relationship. Exp Brain Res. 1972 Oct 29;15(5):452–471. doi: 10.1007/BF00236402. [DOI] [PubMed] [Google Scholar]
- Dubin M. W., Cleland B. G. Organization of visual inputs to interneurons of lateral geniculate nucleus of the cat. J Neurophysiol. 1977 Mar;40(2):410–427. doi: 10.1152/jn.1977.40.2.410. [DOI] [PubMed] [Google Scholar]
- Enroth-Cugell C., Robson J. G. The contrast sensitivity of retinal ganglion cells of the cat. J Physiol. 1966 Dec;187(3):517–552. doi: 10.1113/jphysiol.1966.sp008107. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Fukada Y. Receptive field organization of cat optic nerve fibers with special reference to conduction velocity. Vision Res. 1971 Mar;11(3):209–226. doi: 10.1016/0042-6989(71)90186-6. [DOI] [PubMed] [Google Scholar]
- Fukuda Y., Stone J. Evidence of differential inhibitory influences on X- and Y-type relay cells in the cat's lateral geniculate nucleus. Brain Res. 1976 Aug 20;113(1):188–196. doi: 10.1016/0006-8993(76)90018-4. [DOI] [PubMed] [Google Scholar]
- HUBEL D. H., WIESEL T. N. Integrative action in the cat's lateral geniculate body. J Physiol. 1961 Feb;155:385–398. doi: 10.1113/jphysiol.1961.sp006635. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Hoffmann K. P., Stone J., Sherman S. M. Relay of receptive-field properties in dorsal lateral geniculate nucleus of the cat. J Neurophysiol. 1972 Jul;35(4):518–531. doi: 10.1152/jn.1972.35.4.518. [DOI] [PubMed] [Google Scholar]
- Kelly J. S., Godfraind J. M., Maruyama S. The presence and nature of inhibition in small slices of the dorsal lateral geniculate nucleus of rat and cat incubated in vitro. Brain Res. 1979 May 25;168(2):388–392. doi: 10.1016/0006-8993(79)90180-x. [DOI] [PubMed] [Google Scholar]
- Macgregor R. J., Sharpless S. K., Luttges M. W. A pressure vessel model for nerve compression. J Neurol Sci. 1975 Mar;24(3):299–304. doi: 10.1016/0022-510x(75)90249-x. [DOI] [PubMed] [Google Scholar]
- Ochoa J., Fowler T. J., Gilliatt R. W. Anatomical changes in peripheral nerves compressed by a pneumatic tourniquet. J Anat. 1972 Dec;113(Pt 3):433–455. [PMC free article] [PubMed] [Google Scholar]
- Rodieck R. W. Visual pathways. Annu Rev Neurosci. 1979;2:193–225. doi: 10.1146/annurev.ne.02.030179.001205. [DOI] [PubMed] [Google Scholar]
- Singer W., Bedworth N. Inhibitory interaction between X and Y units in the cat lateral geniculate nucleus. Brain Res. 1973 Jan 30;49(2):291–307. doi: 10.1016/0006-8993(73)90424-1. [DOI] [PubMed] [Google Scholar]
- Singer W., Creutzfeldt O. D. Reciprocal lateral inhibition of on- and off-center neurones in the lateral geniculate body of the cat. Exp Brain Res. 1970;10(3):311–330. doi: 10.1007/BF00235054. [DOI] [PubMed] [Google Scholar]
- Singer W., Pöppel E., Creutzfeldt O. Inhibitory interaction in the cat's lateral geniculate nucleus. Exp Brain Res. 1972;14(2):210–226. doi: 10.1007/BF00234800. [DOI] [PubMed] [Google Scholar]
- Stevens J. K., Gerstein G. L. Interactions between cat lateral geniculate neurons. J Neurophysiol. 1976 Mar;39(2):239–256. doi: 10.1152/jn.1976.39.2.239. [DOI] [PubMed] [Google Scholar]
- Stone J., Dreher B., Leventhal A. Hierarchical and parallel mechanisms in the organization of visual cortex. Brain Res. 1979 Dec;180(3):345–394. doi: 10.1016/0165-0173(79)90010-9. [DOI] [PubMed] [Google Scholar]
- VASTOLA E. F. After-positivity in lateral geniculate body. J Neurophysiol. 1959 May;22(3):258–272. doi: 10.1152/jn.1959.22.3.258. [DOI] [PubMed] [Google Scholar]