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. 1985 Aug;365:121–130. doi: 10.1113/jphysiol.1985.sp015762

Canine bombesin-like gastrin releasing peptides stimulate gastrin release and acid secretion in the dog.

N W Bunnett, B Clark, H T Debas, R C Del Milton, T O Kovacs, M S Orloff, T N Pappas, J R Reeve Jr, J E Rivier, J H Walsh
PMCID: PMC1192992  PMID: 3839849

Abstract

The synthetic mammalian bombesin-like peptides, canine gastrin releasing peptide 27, 23 and 10, and porcine gastrin releasing peptide 27 were compared with amphibian bombesin 14 and 10 during intravenous infusions into six conscious dogs with chronic gastric cannulae. Gastrin and gastrin releasing peptide were measured in peripherally sampled venous blood by radioimmunoassay and gastric acid secretions were collected. All forms of gastrin releasing peptide stimulated gastrin release and gastric acid secretion in a dose-dependent manner. The larger canine and porcine peptides were more potent than the decapeptide. Bombesin 14 was more potent than bombesin 10. A rise in the venous concentration of immunoreactive gastrin releasing peptide of only 20 fmol ml-1 stimulated gastrin release to about 50% of maximal. Gastrin releasing peptide 10 was cleared from the circulation three times faster than the larger forms and this may account for the apparent differences in potency.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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