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. 1984 Jun;351:77–85. doi: 10.1113/jphysiol.1984.sp015233

The direct inhibition of pancreatic electrolyte secretion by noradrenaline in the isolated perfused cat pancreas.

E E Elisha, D Hutson, T Scratcherd
PMCID: PMC1193105  PMID: 6747881

Abstract

The continuous infusion of noradrenaline into the arterial supply of the isolated saline-perfused pancreas caused a dose-dependent rise in perfusion pressure, a reduction in perfusion rate and an inhibition of pancreatic secretion. With increasing dose there was always a greater reduction in secretion rate than there was of perfusate flow rate. Manual reduction of the perfusion rate resulted in a reduction in secretion rate. When noradrenaline reduced the perfusate flow by 44.2 +/- 6.0% the secretion rate fell by 76.6 +/- 14.1%. Manual reduction of the perfusion flow rate by a similar amount (43.0 +/- 5.7%) only reduced the secretion rate by 41.4 +/- 7.0%. The infusion of noradrenaline, when all calcium had been removed from the perfusate, caused only a small increase in perfusion pressure with little change in the perfusion flow whilst at the same time the inhibition of electrolyte secretion was relatively unaffected. The vasomotor and secretory effects of noradrenaline were abolished by phentolamine. It is concluded that noradrenaline inhibits pancreatic electrolyte secretion by a direct action on the secretory cell and indirectly by vasoconstriction and that both these effects are mediated through the alpha-receptor.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Argent B. E., Case R. M., Scratcherd T. Amylase secretion by the perfused cat pancreas in relation to the secretion of calcium and other electrolytes and as influenced by the external ionic environment. J Physiol. 1973 May;230(3):575–593. doi: 10.1113/jphysiol.1973.sp010205. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Barlow T. E., Greenwell J. R., Harper A. A., Scratcherd T. The effect of adrenaline and noradrenaline on the blood flow, electrical conductance and external secretion of the pancreas. J Physiol. 1971 Sep;217(3):665–678. doi: 10.1113/jphysiol.1971.sp009592. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. CRICK J., HARPER A. A., RAPER H. S. On the preparation of secretin and pancreozymin. J Physiol. 1949 Dec;110(3-4):367–376. doi: 10.1113/jphysiol.1949.sp004445. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Case R. M., Harper A. A., Scratcherd T. Water and electrolyte secretion by the perfused pancreas of the cat. J Physiol. 1968 May;196(1):133–149. doi: 10.1113/jphysiol.1968.sp008499. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Chan Y. L. Adrenergic control of bicarbonate absorption in the proximal convoluted tubule of the rat kidney. Pflugers Arch. 1980 Nov;388(2):159–164. doi: 10.1007/BF00584122. [DOI] [PubMed] [Google Scholar]
  6. Demol P., Sarles H. Inhibition of exocrine pancreatic secretion by alpha-adrenergic blocking agents in conscious rats. Arch Int Pharmacodyn Ther. 1980 Jan;243(1):164–176. [PubMed] [Google Scholar]
  7. Denniss A. R., Schneyer L. H., Sucanthapree C., Young J. A. Actions of adrenergic agonists on isolated excretory ducts of submandibular glands. Am J Physiol. 1978 Dec;235(6):F548–F556. doi: 10.1152/ajprenal.1978.235.6.F548. [DOI] [PubMed] [Google Scholar]
  8. Dzieniszewski J., Tiscornia O. M., Palasciano G., Sarles H. Les effets du blocage alpha et bêta adrénergique sur la sécrétion pancréatique exocrine du chien stimulée par la sécrétine et la cholécystokinine-pancréozymine (CCK-PZ) Biol Gastroenterol (Paris) 1974 Apr-May;7(2):131–138. [PubMed] [Google Scholar]
  9. Heidbreder E., Sieber P., Heidland A. Exokrine Pankreasfunktion unter dem Einfluss vorwiegend alpha-adrenerger Substanzen, indirekter Sympathomimetica und Dopamin. Untersuchungen am isolierten Organ der Katze. Res Exp Med (Berl) 1978 Jan 30;172(1):97–108. doi: 10.1007/BF01851069. [DOI] [PubMed] [Google Scholar]
  10. Hubel K. A. Response of rabbit pancreas in vitro to adrenergic agonists and antagonists. Am J Physiol. 1970 Dec;219(6):1590–1594. doi: 10.1152/ajplegacy.1970.219.6.1590. [DOI] [PubMed] [Google Scholar]
  11. Lingard J. M., Young J. A. beta-Adrenergic control of exocrine secretion by perfused rat pancreas in vitro. Am J Physiol. 1983 Nov;245(5 Pt 1):G690–G696. doi: 10.1152/ajpgi.1983.245.5.G690. [DOI] [PubMed] [Google Scholar]
  12. Pearson G. T., Singh J., Daoud M. S., Davison J. S., Petersen O. H. Control of pancreatic cyclic nucleotide levels and amylase secretion by noncholinergic, nonadrenergic nerves. A study employing electrical field stimulation of guinea pig segments. J Biol Chem. 1981 Nov 10;256(21):11025–11031. [PubMed] [Google Scholar]
  13. TANKEL H. I., HOLLANDER F. The relation between pancreatic secretion and local blood flow: a review. Gastroenterology. 1957 Apr;32(4):633–641. [PubMed] [Google Scholar]
  14. Vaysse N., Bastie M. J., Pascal J. P., Martinel C., Fourtanier G., Ribet A. Effects of catecholamines and their inhibitors on the isolated canine pancreas. I. Noradrenaline and isoprenaline. Gastroenterology. 1977 Apr;72(4 Pt 1):711–718. [PubMed] [Google Scholar]

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