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. 1984 Jun;351:87–98. doi: 10.1113/jphysiol.1984.sp015234

Some properties of excitatory junction currents recorded from submucosal arterioles of guinea-pig ileum.

A S Finkel, G D Hirst, D F Van Helden
PMCID: PMC1193106  PMID: 6086906

Abstract

Excitatory junction potentials and excitatory junction currents have been recorded from short segments of arterioles taken from the submucosa of guinea-pig small intestine. Excitatory junction currents reached their peak amplitudes by 20 ms and then decayed, with a time course that could be described by a single exponential (mean time constant of decay approximately 50 ms). The null potential for excitatory junction currents obtained by extrapolation was near 0 mV. The time course of excitatory junction currents failed to show voltage sensitivity. Spontaneous excitatory junction currents had the same time course as evoked currents; the amplitudes of spontaneous currents were less than an order of magnitude different from that of evoked currents.

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Selected References

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  1. Anderson C. R., Stevens C. F. Voltage clamp analysis of acetylcholine produced end-plate current fluctuations at frog neuromuscular junction. J Physiol. 1973 Dec;235(3):655–691. doi: 10.1113/jphysiol.1973.sp010410. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Bell C. Transmission from vasoconstrictor and vasodilator nerves to single smooth muscle cells of the guinea-pig uterine artery. J Physiol. 1969 Dec;205(3):695–708. doi: 10.1113/jphysiol.1969.sp008991. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Blakeley A. G., Cunnane T. C. The packeted release of transmitter from the sympathetic nerves of the guinea-pig vas deferens: an electrophysiological study. J Physiol. 1979 Nov;296:85–96. doi: 10.1113/jphysiol.1979.sp012992. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Bywater R. A., Taylor G. S. The passive membrane properties and excitatory junction potentials of the guinea pig deferens. J Physiol. 1980 Mar;300:303–316. doi: 10.1113/jphysiol.1980.sp013163. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Derkach V. A., Selyanko A. A., Skok V. I. Acetylcholine-induced current fluctuations and fast excitatory post-synaptic currents in rabbit sympathetic neurones. J Physiol. 1983 Mar;336:511–526. doi: 10.1113/jphysiol.1983.sp014595. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Dudel J. Nonlinear voltage dependence of excitatory synaptic current in crayfish muscle. Pflugers Arch. 1974;352(3):227–241. doi: 10.1007/BF00590488. [DOI] [PubMed] [Google Scholar]
  7. FATT P., KATZ B. An analysis of the end-plate potential recorded with an intracellular electrode. J Physiol. 1951 Nov 28;115(3):320–370. doi: 10.1113/jphysiol.1951.sp004675. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Finkel A. S. A cholinergic chloride conductance in neurones of Helix aspersa. J Physiol. 1983 Nov;344:119–135. doi: 10.1113/jphysiol.1983.sp014928. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Finkel A. S., Redman S. J. The synaptic current evoked in cat spinal motoneurones by impulses in single group 1a axons. J Physiol. 1983 Sep;342:615–632. doi: 10.1113/jphysiol.1983.sp014872. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Gage P. W. Generation of end-plate potentials. Physiol Rev. 1976 Jan;56(1):177–247. doi: 10.1152/physrev.1976.56.1.177. [DOI] [PubMed] [Google Scholar]
  11. Ginsborg B. L. Ion movements in junctional transmission. Pharmacol Rev. 1967 Sep;19(3):289–316. [PubMed] [Google Scholar]
  12. Hirst G. D., Neild T. O. An analysis of excitatory junctional potentials recorded from arterioles. J Physiol. 1978 Jul;280:87–104. doi: 10.1113/jphysiol.1978.sp012374. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Hirst G. D., Neild T. O. Localization of specialized noradrenaline receptors at neuromuscular junctions on arterioles of the guinea-pig. J Physiol. 1981;313:343–350. doi: 10.1113/jphysiol.1981.sp013669. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Hirst G. D., Neild T. O. Some properties of spontaneous excitatory junction potentials recorded from arterioles of guinea-pigs. J Physiol. 1980 Jun;303:43–60. doi: 10.1113/jphysiol.1980.sp013269. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. Hirst G. D. Neuromuscular transmission in arterioles of guinea-pig submucosa. J Physiol. 1977 Dec;273(1):263–275. doi: 10.1113/jphysiol.1977.sp012093. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. Hirst G. D., van Helden D. F. Ionic basis of the resting potential of submucosal arterioles in the ileum of the guinea-pig. J Physiol. 1982 Dec;333:53–67. doi: 10.1113/jphysiol.1982.sp014438. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. Holman M. E., Surprenant A. M. Some properties of the excitatory junction potentials recorded from saphenous arteries of rabbits. J Physiol. 1979 Feb;287:337–351. doi: 10.1113/jphysiol.1979.sp012663. [DOI] [PMC free article] [PubMed] [Google Scholar]
  18. Hua C., Cragg B. Measurements of smooth muscle cells in arterioles of guinea pig ileum. Acta Anat (Basel) 1980;107(2):224–230. doi: 10.1159/000145246. [DOI] [PubMed] [Google Scholar]
  19. Ito Y., Kuriyama H., Sakamoto Y. Effects of tetraethylammonium chloride on the membrane activity of guinea-pig stomach smooth muscle. J Physiol. 1970 Dec;211(2):445–460. doi: 10.1113/jphysiol.1970.sp009286. [DOI] [PMC free article] [PubMed] [Google Scholar]
  20. Kuriyama H., Suzuki H. Adrenergic transmissions in the guinea-pig mesenteric artery and their cholinergic modulations. J Physiol. 1981 Aug;317:383–396. doi: 10.1113/jphysiol.1981.sp013831. [DOI] [PMC free article] [PubMed] [Google Scholar]
  21. Magleby K. L., Stevens C. F. The effect of voltage on the time course of end-plate currents. J Physiol. 1972 May;223(1):151–171. doi: 10.1113/jphysiol.1972.sp009839. [DOI] [PMC free article] [PubMed] [Google Scholar]
  22. Onodera K., Takeuchi A. Effects of membrane potential and temperature on the excitatory post-synaptic current in the crayfish muscle. J Physiol. 1978 Mar;276:183–192. doi: 10.1113/jphysiol.1978.sp012227. [DOI] [PMC free article] [PubMed] [Google Scholar]
  23. Rang H. P. The characteristics of synaptic currents and responses to acetylcholine of rat submandibular ganglion cells. J Physiol. 1981 Feb;311:23–55. doi: 10.1113/jphysiol.1981.sp013571. [DOI] [PMC free article] [PubMed] [Google Scholar]
  24. Suzuki H. An electrophysiological study of excitatory neuromuscular transmission in the guinea-pig main pulmonary artery. J Physiol. 1983 Mar;336:47–59. doi: 10.1113/jphysiol.1983.sp014565. [DOI] [PMC free article] [PubMed] [Google Scholar]
  25. TAKEUCHI A., TAKEUCHI N. Active phase of frog's end-plate potential. J Neurophysiol. 1959 Jul;22(4):395–411. doi: 10.1152/jn.1959.22.4.395. [DOI] [PubMed] [Google Scholar]

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