Abstract
The effect of the periodic interdigestive activity of the gut on secretin-stimulated pancreatic secretion was studied in eight conscious dogs each with a Thomas duodenal fistula, a gastric fistula and a Heidenhain pouch. Pancreatic water and bicarbonate responses to a small dose of secretin were greatly augmented in phase with the spontaneous periodic activity of the gut. This augmentation was closely related to pancreatic protein secretion. As the dose of secretin was increased the interval between peaks was prolonged, the peaks became less sharp, the nadirs were raised, and finally the periodic activity was no longer seen. Bilateral cervical vagal blockade with local anaesthetics reduced the secretin-stimulated bicarbonate secretion by 50% but the augmentation at the peak was not abolished. Atropine abolished the periodic augmentation completely and reduced the bicarbonate response by 80%. The peak response of volume and bicarbonate to secretin obeyed Michaelis-Menten kinetics. The nadir secretin dose response, however, was a sigmoid curve with a Hill coefficient larger than one. The action of atropine or hexamethonium was to shift the peak response kinetics to the nadir kinetics. It is concluded that the pancreatic response to secretin is greatly modulated by the spontaneous periodic activity of nerves.
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Selected References
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- Devaux M. A., Diaz G. R., Kubota K., Magee D. F., Sarles H. The role of nicotinic receptors in dog pancreatic exocrine secretion. Br J Pharmacol. 1983 Apr;78(4):623–628. doi: 10.1111/j.1476-5381.1983.tb09412.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Hong S. S., Magee D. F. Pharmacological studies on the regulation of pancreatic secretion in pigs. Ann Surg. 1970 Jul;172(1):41–48. [PMC free article] [PubMed] [Google Scholar]
- Kim M. S., Lee K. Y., Chey W. Y. Plasma secretin concentrations in fasting and postprandial states in dog. Am J Physiol. 1979 May;236(5):E539–E544. doi: 10.1152/ajpendo.1979.236.5.E539. [DOI] [PubMed] [Google Scholar]
- MAGEE D. F., FRAGOLA L. A., WHITE T. T. INFLUENCE OF PARASYMPATHETIC INNERVATION ON THE VOLUME OF PANCREATIC JUICE. Ann Surg. 1965 Jan;161:15–20. doi: 10.1097/00000658-196501000-00002. [DOI] [PMC free article] [PubMed] [Google Scholar]
- MONOD J., CHANGEUX J. P., JACOB F. Allosteric proteins and cellular control systems. J Mol Biol. 1963 Apr;6:306–329. doi: 10.1016/s0022-2836(63)80091-1. [DOI] [PubMed] [Google Scholar]
- Magee D. F. A consideration of the cholinergic nerve supply to the pancreas. Mt Sinai J Med. 1982 Mar-Apr;49(2):94–101. [PubMed] [Google Scholar]
- Magee D. F., Naruse S. Effect of pancreatic juice on basal pancreatic and gastric secretion in dogs. J Physiol. 1982 Sep;330:489–496. doi: 10.1113/jphysiol.1982.sp014354. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Magee D. F., Naruse S. Neural control of periodic secretion of the pancreas and the stomach in fasting dogs. J Physiol. 1983 Nov;344:153–160. doi: 10.1113/jphysiol.1983.sp014930. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Mukhopadhyay A. K., Johnson L. R., Copeland E. M., Weisbrodt N. W. Effect of secretin on electrical activity of small intestine. Am J Physiol. 1975 Aug;229(2):484–488. doi: 10.1152/ajplegacy.1975.229.2.484. [DOI] [PubMed] [Google Scholar]
- Singer M. V., Solomon T. E., Rammert H., Caspary F., Niebel W., Goebell H., Grossman M. I. Effect of atropine on pancreatic response to HCl and secretin. Am J Physiol. 1981 May;240(5):G376–G380. doi: 10.1152/ajpgi.1981.240.5.G376. [DOI] [PubMed] [Google Scholar]
- Vaysse N., Bastié M. J., Pascal J. P., Roux P., Martinel C. H., Lacroix A., Ribet A. Role of cholinergic mechanisms in the response to secretin of isolated canine pancreas. Gastroenterology. 1975 Dec;69(6):1269–1277. [PubMed] [Google Scholar]