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. 1984 Jul;352:103–112. doi: 10.1113/jphysiol.1984.sp015280

Effect of cooling on supraoptic neurohypophysial neuronal activity and on urine flow in the rat.

A V Ferguson, Q J Pittman, C L Riphagen
PMCID: PMC1193200  PMID: 6747884

Abstract

The activity of antidromically identified supraoptic neurosecretory neurones was recorded in Sprague-Dawley rats under urethane or sodium pentobarbitone anaesthesia during cooling of the body with a cold pack. Of twelve phasic neurones studied during a complete cooling and rewarming cycle, six displayed an initial increase, followed by a depression in activity during the period of reduced body temperature. The remaining six phasic neurones did not alter their activity during cooling. Non-phasic neurohypophysial neurones displayed a reversible reduction (n = 8), or increase (n = 6) in activity during cooling, while seven neurones were unaffected by changes in body temperature. In four other anaesthetized Sprague-Dawley rats, urine flow was reduced by approximately 50% during cooling; this was followed by a diuresis after removal of the cold pack and return of body temperature to normal. The antidiuresis did not occur in homozygous Brattleboro rats which lack arginine vasopressin. The electrophysiological data from a proportion of the supraoptic neurohypophysial neurones correlate with the observed changes in urine flow.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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