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. 1984 Aug;353:187–197. doi: 10.1113/jphysiol.1984.sp015331

Phasic modulation of trunk muscle efferents during fictive spinal locomotion in cats.

W J Koehler, E D Schomburg, H Steffens
PMCID: PMC1193302  PMID: 6237190

Abstract

In high spinal paralysed cats electromyograms were recorded from nerves supplying lumbar back muscles (longissimus dorsi) and abdominal muscles (obliquus abdominis externus) during fictive locomotion induced by I.V. injection of nialamide and L-DOPA. Activity in nerves to hind-limb muscles was also recorded. During periods of stable 'locomotor' activity in the hind-limb nerves the efferents to the back and abdominal trunk muscles were generally also rhythmically active. Three different patterns of activity were observed. The predominant rhythmic pattern showed a synchronous activation of the efferents to the back and abdominal muscles of one side together with an activation of the hind-limb flexors of that side, alternating with activation of the efferents to the corresponding contralateral muscles. This pattern was very stable and could last for about 3 h. Such a pattern of activity would be expected during the alternate stepping characteristic of walking and trotting. The second type of rhythmic locomotor activity was characterized by a synchronous bilateral activation of the efferents to the back muscles, alternating with activation of the abdominal muscles on both sides. This pattern occurred only for short periods and appears to correspond to the activity during in-phase stepping such as occurs during a gallop. Beside these well co-ordinated patterns less well co-ordinated rhythmic activities were also observed. These included regular rhythmic activity which occurred independently in different muscle groups as well as irregular rhythmic activity with unstable phase relations between different muscle groups. The rhythmic locomotor activity in efferents to trunk and limb muscles could be modulated by afferent nerve stimulation and by hypoxia. The results reveal that the spinal cord deprived of its supraspinal and peripheral control may generate a variety of different locomotor patterns, which incorporate the trunk muscles in an apparently meaningful way.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Andersson O., Grillner S., Lindquist M., Zomlefer M. Peripheral control of the spinal pattern generators for locomotion in cat. Brain Res. 1978 Jul 21;150(3):625–630. doi: 10.1016/0006-8993(78)90827-2. [DOI] [PubMed] [Google Scholar]
  2. Andersson O., Grillner S. Peripheral control of the cat's step cycle. I. Phase dependent effects of ramp-movements of the hip during "fictive locomotion". Acta Physiol Scand. 1981 Sep;113(1):89–101. doi: 10.1111/j.1748-1716.1981.tb06867.x. [DOI] [PubMed] [Google Scholar]
  3. Aoki M., Mori S., Kawahara K., Watanabe H., Ebata N. Generation of spontaneous respiratory rhythm in high spinal cats. Brain Res. 1980 Nov 24;202(1):51–63. [PubMed] [Google Scholar]
  4. Brown T. G. On the activities of the central nervous system of the un-born foetus of the cat; with a discussion of the question whether progression (walking, etc.) is a "learnt" complex. J Physiol. 1915 May 12;49(4):208–215. doi: 10.1113/jphysiol.1915.sp001704. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Brown T. G. On the nature of the fundamental activity of the nervous centres; together with an analysis of the conditioning of rhythmic activity in progression, and a theory of the evolution of function in the nervous system. J Physiol. 1914 Mar 31;48(1):18–46. doi: 10.1113/jphysiol.1914.sp001646. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Carlson H., Halbertsma J., Zomlefer M. Control of the trunk during walking in the cat. Acta Physiol Scand. 1979 Feb;105(2):251–253. doi: 10.1111/j.1748-1716.1979.tb06338.x. [DOI] [PubMed] [Google Scholar]
  7. Engberg I., Lundberg A. An electromyographic analysis of muscular activity in the hindlimb of the cat during unrestrained locomotion. Acta Physiol Scand. 1969 Apr;75(4):614–630. doi: 10.1111/j.1748-1716.1969.tb04415.x. [DOI] [PubMed] [Google Scholar]
  8. Grillner S. Locomotion in vertebrates: central mechanisms and reflex interaction. Physiol Rev. 1975 Apr;55(2):247–304. doi: 10.1152/physrev.1975.55.2.247. [DOI] [PubMed] [Google Scholar]
  9. Grillner S. On the generation of locomotion in the spinal dogfish. Exp Brain Res. 1974;20(5):459–470. doi: 10.1007/BF00238013. [DOI] [PubMed] [Google Scholar]
  10. Grillner S., Zangger P. On the central generation of locomotion in the low spinal cat. Exp Brain Res. 1979 Jan 15;34(2):241–261. doi: 10.1007/BF00235671. [DOI] [PubMed] [Google Scholar]
  11. Jankowska E., Jukes M. G., Lund S., Lundberg A. The effect of DOPA on the spinal cord. 5. Reciprocal organization of pathways transmitting excitatory action to alpha motoneurones of flexors and extensors. Acta Physiol Scand. 1967 Jul-Aug;70(3):369–388. doi: 10.1111/j.1748-1716.1967.tb03636.x. [DOI] [PubMed] [Google Scholar]
  12. Jankowska E., Jukes M. G., Lund S., Lundberg A. The effect of DOPA on the spinal cord. 6. Half-centre organization of interneurones transmitting effects from the flexor reflex afferents. Acta Physiol Scand. 1967 Jul-Aug;70(3):389–402. doi: 10.1111/j.1748-1716.1967.tb03637.x. [DOI] [PubMed] [Google Scholar]
  13. Kniffki K. D., Schomburg E. D., Steffens H. Effects from fine muscle and cutaneous afferents on spinal locomotion in cats. J Physiol. 1981;319:543–554. doi: 10.1113/jphysiol.1981.sp013925. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Miller S., Scott P. D. The spinal locomotor generator. Exp Brain Res. 1977 Nov 24;30(2-3):387–403. doi: 10.1007/BF00237264. [DOI] [PubMed] [Google Scholar]
  15. Perret C., Millanvoye M., Cabelguen J. M. Messages spinaux ascendants pendant une locomotion fictive chez le chat curarisé. J Physiol (Paris) 1972;65(Suppl):153A–153A. [PubMed] [Google Scholar]
  16. Shik M. L., Orlovsky G. N. Neurophysiology of locomotor automatism. Physiol Rev. 1976 Jul;56(3):465–501. doi: 10.1152/physrev.1976.56.3.465. [DOI] [PubMed] [Google Scholar]
  17. Viala D., Buser P. Modalitś d'obtention de rythmes locomoteurs chez le lapin spinal par traitements pharmacologiques (DOPA, 5-HTP, D-amphétamine. Brain Res. 1971 Dec 10;35(1):151–165. doi: 10.1016/0006-8993(71)90601-9. [DOI] [PubMed] [Google Scholar]
  18. Viala D., Freton E. Evidence for respiratory and locomotor pattern generators in the rabbit cervico-thoracic cord and for their interactions. Exp Brain Res. 1983;49(2):247–256. doi: 10.1007/BF00238584. [DOI] [PubMed] [Google Scholar]
  19. Viala D., Vidal C., Freton E. Coordinated rhythmic bursting in respiratory and locomotor muscle nerves in the spinal rabbit. Neurosci Lett. 1979 Feb;11(2):155–159. doi: 10.1016/0304-3940(79)90119-8. [DOI] [PubMed] [Google Scholar]
  20. Viala G., Orsal D., Buser P. Cutaneous fiber groups involved in the inhibition of fictive locomotion in the rabbit. Exp Brain Res. 1978 Oct 13;33(2):257–267. doi: 10.1007/BF00238064. [DOI] [PubMed] [Google Scholar]
  21. Webb P. W. The swimming energetics of trout. I. Thrust and power output at cruising speeds. J Exp Biol. 1971 Oct;55(2):489–520. doi: 10.1242/jeb.55.2.489. [DOI] [PubMed] [Google Scholar]

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