Skip to main content
NCBI home page
The Journal of Physiology logoLink to The Journal of Physiology
. 1985 Jan;358:405–416. doi: 10.1113/jphysiol.1985.sp015558

Effect of cephalic carbon dioxide tension on the cardiac inotropic response to carotid chemoreceptor stimulation in dogs.

R Hainsworth, A J Rankin, A O Soladoye
PMCID: PMC1193349  PMID: 3920387

Abstract

Dogs were anaesthetized with chloralose and the cephalic circulation was perfused, through the brachiocephalic and left subclavian arteries, with blood equilibrated with various tensions of CO2. The vascularly isolated carotid bifurcations were perfused at a constant pressure with either arterial or venous blood. Inotropic responses were assessed by measuring the maximum rate of change of left ventricular pressure (dP/dt max) with heart rate and aortic pressure held constant. Stimulation of carotid chemoreceptors with venous blood, at all values of cephalic PCO2, always resulted in a decrease in dP/dt max. An increase in cephalic PCO2, during arterial perfusion of chemoreceptors, resulted in an increase in dP/dt max and the response to chemoreceptor stimulation was enhanced. Graded changes in cephalic PCO2 resulted in graded changes in dP/dt max during arterial perfusion of chemoreceptors. However, the value of dP/dt max during venous perfusion was not significantly affected by increases in cephalic PCO2 above normal but it did decrease significantly during cephalic hypocapnia. These results confirm that an increase in cephalic PCO2 and stimulation of carotid chemoreceptors result in opposite responses of the cardiac inotropic state. The responses to chemoreceptor stimulation were enhanced by cephalic hypercapnia but the responses to cephalic hypercapnia, although not to hypocapnia, were suppressed by chemoreceptor stimulation.

Full text

PDF
405

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Achtel R. A., Downing S. E. Ventricular responses to hypoxemia following chemoreceptor denervation and adrenalectomy. Am Heart J. 1972 Sep;84(3):377–386. doi: 10.1016/0002-8703(72)90371-7. [DOI] [PubMed] [Google Scholar]
  2. Biscoe T. J., Purves M. J., Sampson S. R. The frequency of nerve impulses in single carotid body chemoreceptor afferent fibres recorded in vivo with intact circulation. J Physiol. 1970 May;208(1):121–131. doi: 10.1113/jphysiol.1970.sp009109. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. De Geest H., Levy M. N., Zieske H. Carotid chemoreceptor stimulation and ventricular performance. Am J Physiol. 1965 Sep;209(3):564–570. doi: 10.1152/ajplegacy.1965.209.3.564. [DOI] [PubMed] [Google Scholar]
  4. DeGeest H., Levy M. N., Zieske H. Reflex effects of cephalic hypoxia, hypercapnia, and ischemia upon ventricular contractility. Circ Res. 1965 Oct;17(4):349–358. doi: 10.1161/01.res.17.4.349. [DOI] [PubMed] [Google Scholar]
  5. Furnival C. M., Linden R. J., Snow H. M. Inotropic changes in the left ventricle: the effect of changes in heart rate, aortic pressure and end-diastolic pressure. J Physiol. 1970 Dec;211(2):359–387. doi: 10.1113/jphysiol.1970.sp009283. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Hainsworth R., Karim F. Left ventricular inotropic and peripheral vasomotor responses from independent changes in pressure in the carotid sinuses and cerebral arteries in anaesthetized dogs. J Physiol. 1973 Jan;228(1):139–155. doi: 10.1113/jphysiol.1973.sp010077. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Hainsworth R., Karim F., Sofola O. A. Left ventricular inotropic responses to stimulation of carotid body chemoreceptors in anaesthetized dogs. J Physiol. 1979 Feb;287:455–466. doi: 10.1113/jphysiol.1979.sp012670. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Hainsworth R., McGregor K. H., Rankin A. J., Soladoye A. O. Cardiac inotropic responses from changes in carbon dioxide tension in the cephalic circulation of anaesthetized dogs. J Physiol. 1984 Dec;357:23–35. doi: 10.1113/jphysiol.1984.sp015486. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. KAHLER R. L., GOLDBLATT A., BRAUNWALD E. The effects of acute hypoxia on the systemic venous and arterial systems and on myocardial contractile force. J Clin Invest. 1962 Jul;41:1553–1563. doi: 10.1172/JCI104612. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Karim F., Hainsworth R., Sofola O. A., Wood L. M. Responses of the heart to stimulation of aortic body chemoreceptors in dogs. Circ Res. 1980 Jan;46(1):77–83. doi: 10.1161/01.res.46.1.77. [DOI] [PubMed] [Google Scholar]
  11. Krasney J. A., Koehler R. C. Influence of arterial hypoxia on cardiac and coronary dynamics in the conscious sinoaortic-denervated dog. J Appl Physiol Respir Environ Exerc Physiol. 1977 Dec;43(6):1012–1018. doi: 10.1152/jappl.1977.43.6.1012. [DOI] [PubMed] [Google Scholar]
  12. NEAL J. J., Jr, HALPERN W., REEVES T. J. Velocity and acceleration of pressure change in heart and arteries. J Appl Physiol. 1960 Jul;15:747–749. doi: 10.1152/jappl.1960.15.4.747. [DOI] [PubMed] [Google Scholar]
  13. Neil E., O'Regan R. G. The effects of electrical stimulation of the distal end of the cut sinus and aortic nerves on peripheral arterial chemoreceptor activity in the cat. J Physiol. 1971 May;215(1):15–32. doi: 10.1113/jphysiol.1971.sp009455. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. SAGAWA K., ROSS J. M., GUYTON A. C. Quantitation of cerebral ischemic pressor response in dogs. Am J Physiol. 1961 Jun;200:1164–1168. doi: 10.1152/ajplegacy.1961.200.6.1164. [DOI] [PubMed] [Google Scholar]
  15. Spyer K. M. Neural organisation and control of the baroreceptor reflex. Rev Physiol Biochem Pharmacol. 1981;88:24–124. [PubMed] [Google Scholar]
  16. de Burgh Daly M., Elsner R., Angell-James J. E. Cardiorespiratory control by carotid chemoreceptors during experimental dives in the seal. Am J Physiol. 1977 May;232(5):H508–H516. doi: 10.1152/ajpheart.1977.232.5.H508. [DOI] [PubMed] [Google Scholar]
  17. van den Bos G. C., Drake A. J., Noble M. I. The effect of carbon dioxide upon myocardial contractile performance, blood flow and oxygen consumption. J Physiol. 1979 Feb;287:149–161. doi: 10.1113/jphysiol.1979.sp012651. [DOI] [PMC free article] [PubMed] [Google Scholar]

Articles from The Journal of Physiology are provided here courtesy of The Physiological Society

RESOURCES