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. 1984 Oct;355:1–9. doi: 10.1113/jphysiol.1984.sp015401

Rate of change of alveolar carbon dioxide and the control of ventilation during exercise.

C J Allen, N L Jones
PMCID: PMC1193473  PMID: 6436474

Abstract

The relationship between rate of change of alveolar PCO2 (delta PA, CO2/delta te), CO2 output (VCO2) and ventilation (VE) has been determined following a rapid increase in exercise intensity, to test the hypothesis that VE is related to VCO2 by a feed-forward control system responding to delta PA, CO2/delta te. There was a close relationship between delta PA, CO2/delta te and VCO2 (delta PA, CO2/delta te = 3.2 VCO2 + 0.85), but delta PA, CO2/delta te increased more rapidly than VCO2. Increases in mean inspiratory flow, an index of inspiratory drive, were more closely related to changes in delta PA, CO2/delta te than to changes in VCO2. Increases in VE during transient and steady-state conditions may be described by the equation: VE = 6.76 delta PA, CO2/delta te -3.50, a relationship which is consistent with a feed-forward control system.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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