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. 1983 Oct;343:495–506. doi: 10.1113/jphysiol.1983.sp014905

The effect of cooling on breathing and shivering in unanaesthetized fetal lambs in utero.

P D Gluckman, T R Gunn, B M Johnston
PMCID: PMC1193932  PMID: 6644623

Abstract

The effects of cooling have been studied in chronically instrumented unanaesthetized fetal lambs of 106-132 days gestation. Cold stimulation of cutaneous thermoreceptors by means of a coil placed around the fetus in the amniotic cavity induced continuous breathing which was associated with high-voltage electrocortical activity throughout the cooling period. Direct internal cooling by means of an intragastric cooling coil did not alter fetal breathing or sleep-state patterns. Shivering occurred in response to both external and internal cooling, and this response was present as early as 106 days gestation, well before the appearance of high-voltage sleep. In older fetuses there was evidence of a reduction in thermoregulatory responses during low-voltage electrocortical activity, but not of the complete suspension of thermoregulation characteristic of low-voltage (r.e.m.) sleep seen in mature animals. It is concluded that deep regular breathing associated with high-voltage electrocortical activity can be induced by cold stimulation of cutaneous thermoreceptors, but not by a reduction in core temperature alone. Furthermore, fetal responses to cooling are present as early as 106 days gestation.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Alexander G. Body temperature control in mammalian young. Br Med Bull. 1975 Jan;31(1):62–68. doi: 10.1093/oxfordjournals.bmb.a071243. [DOI] [PubMed] [Google Scholar]
  2. Alexander G., Williams D. Cardiovascular function in young lambs during summit metabolism. J Physiol. 1970 May;208(1):65–83. doi: 10.1113/jphysiol.1970.sp009106. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Alexander G., Williams D. Shivering and non-shivering therogenesis during summit metabolism in young lambs. J Physiol. 1968 Sep;198(2):251–276. doi: 10.1113/jphysiol.1968.sp008605. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Boddy K., Dawes G. S., Fisher R., Pinter S., Robinson J. S. Foetal respiratory movements, electrocortical and cardiovascular responses to hypoxaemia and hypercapnia in sheep. J Physiol. 1974 Dec;243(3):599–618. doi: 10.1113/jphysiol.1974.sp010768. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Clewlow F., Dawes G. S., Johnston B. M., Walker D. W. Changes in breathing, electrocortical and muscle activity in unanaesthetized fetal lambs with age. J Physiol. 1983 Aug;341:463–476. doi: 10.1113/jphysiol.1983.sp014817. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Dalton K. J., Dawes G. S., Patrick J. E. Diurnal, respiratory, and other rhythms of fetal heart rate in lambs. Am J Obstet Gynecol. 1977 Feb 15;127(4):414–424. doi: 10.1016/0002-9378(77)90500-2. [DOI] [PubMed] [Google Scholar]
  7. Darnall R. A., Jr, Ariagno R. L. The effect of sleep state on active thermoregulation in the premature infant. Pediatr Res. 1982 Jul;16(7):512–514. doi: 10.1203/00006450-198207000-00002. [DOI] [PubMed] [Google Scholar]
  8. Dawes G. S., Fox H. E., Leduc B. M., Liggins G. C., Richards R. T. Respiratory movements and rapid eye movement sleep in the foetal lamb. J Physiol. 1972 Jan;220(1):119–143. doi: 10.1113/jphysiol.1972.sp009698. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Dawes G. S., Gardner W. N., Johnston B. M., Walker D. W. Breathing in fetal lambs: the effect of brain stem section. J Physiol. 1983 Feb;335:535–553. doi: 10.1113/jphysiol.1983.sp014549. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Glotzbach S. F., Heller H. C. Central nervous regulation of body temperature during sleep. Science. 1976 Oct 29;194(4264):537–539. doi: 10.1126/science.973138. [DOI] [PubMed] [Google Scholar]
  11. Gluckman P. D., Mueller P. L., Kaplan S. L., Rudolph A. M., Grumbach M. M. Hormone ontogeny in the ovine fetus. I. Circulating growth hormone in mid and late gestation. Endocrinology. 1979 Jan;104(1):162–168. doi: 10.1210/endo-104-1-162. [DOI] [PubMed] [Google Scholar]
  12. Hales J. R., Bligh J., Maskrey M. Cerebrospinal fluid acid-base balance during respiratory alkalosis in the panting animal. Am J Physiol. 1970 Aug;219(2):469–473. doi: 10.1152/ajplegacy.1970.219.2.469. [DOI] [PubMed] [Google Scholar]
  13. Harding R., Johnson P., McClelland M. E. Respiratory function of the larynx in developing sheep and the influence of sleep state. Respir Physiol. 1980 May;40(2):165–179. doi: 10.1016/0034-5687(80)90090-0. [DOI] [PubMed] [Google Scholar]
  14. Harding R. State-related and developmental changes in laryngeal function. Sleep. 1980;3(3-4):307–322. doi: 10.1093/sleep/3.3-4.307. [DOI] [PubMed] [Google Scholar]
  15. Harned H. S., Jr, Ferreiro J. Initiation of breathing by cold stimulation: effects of change in ambient temperature on respiratory activity of the full-term fetal lamb. J Pediatr. 1973 Oct;83(4):663–669. doi: 10.1016/s0022-3476(73)80237-9. [DOI] [PubMed] [Google Scholar]
  16. Jost R. G., Quilligan E. J., Yeh S. Y., Anderson G. G. Intrauterine electroencephalogram of the sheep fetus. Am J Obstet Gynecol. 1972 Oct 15;114(4):535–539. doi: 10.1016/0002-9378(72)90216-5. [DOI] [PubMed] [Google Scholar]
  17. Parmeggiani P. L., Rabini C. Shivering and panting during sleep. Brain Res. 1967 Dec;6(4):789–791. doi: 10.1016/0006-8993(67)90139-4. [DOI] [PubMed] [Google Scholar]
  18. Phillipson E. A. Control of breathing during sleep. Am Rev Respir Dis. 1978 Nov;118(5):909–939. doi: 10.1164/arrd.1978.118.5.909. [DOI] [PubMed] [Google Scholar]
  19. Sullivan C. E., Kozar L. F., Murphy E., Phillipson E. A. Primary role of respiratory afferents in sustaining breathing rhythm. J Appl Physiol Respir Environ Exerc Physiol. 1978 Jul;45(1):11–17. doi: 10.1152/jappl.1978.45.1.11. [DOI] [PubMed] [Google Scholar]
  20. Walker J. M., Berger R. J. The ontogenesis of sleep states, thermogenesis, and thermoregulation in the Virginia opossum. Dev Psychobiol. 1980 Sep;13(5):443–454. doi: 10.1002/dev.420130502. [DOI] [PubMed] [Google Scholar]
  21. Wilds P. L. Observations of intrauterine fetal breathing movements--a review. Am J Obstet Gynecol. 1978 Jun 1;131(3):315–338. doi: 10.1016/0002-9378(78)90609-9. [DOI] [PubMed] [Google Scholar]

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