Abstract
The zinc status of 19 patients with chronic or recurrent genital infections and 18 patients with non-recurrent genital infections was assessed by measuring plasma and leucocyte zinc concentrations. Neither group of patients had plasma or leucocyte zinc concentrations that differed significantly from those of matched healthy controls. Each of six patients with chronic candidiasis had anergy to candidal antigen, as shown by delayed cutaneous hypersensitivity to intradermal injection of the antigen, but their zinc status was normal. This study provided no evidence of zinc deficiency in this small number of patients with acute non-recurrent or chronic recurrent genital infections.
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- Aggett P. J., Harries J. T. Current status of zinc in health and disease states. Arch Dis Child. 1979 Dec;54(12):909–917. doi: 10.1136/adc.54.12.909. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Barnett N., Mak H., Winkelstein J. A. Extensive verrucosis in primary immunodeficiency diseases. Arch Dermatol. 1983 Jan;119(1):5–7. [PubMed] [Google Scholar]
- Delves H. T. Assessment of trace element status. Clin Endocrinol Metab. 1985 Aug;14(3):725–760. doi: 10.1016/s0300-595x(85)80014-1. [DOI] [PubMed] [Google Scholar]
- Donnenberg A. D., Chaikof E., Aurelian L. Immunity to herpes simplex virus type 2: cell-mediated immunity in latently infected guinea pigs. Infect Immun. 1980 Oct;30(1):99–109. doi: 10.1128/iai.30.1.99-109.1980. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Fahim M. S., Brawner T. A. Treatment of genital herpes simplex virus in male patients. Arch Androl. 1980 Feb;4(1):79–85. doi: 10.3109/01485018008988283. [DOI] [PubMed] [Google Scholar]
- Gordon Y. J., Asher Y., Becker Y. Irreversible inhibition of herpes simplex virus replication in BSC-1 cells by zinc ions. Antimicrob Agents Chemother. 1975 Sep;8(3):377–380. doi: 10.1128/aac.8.3.377. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Hinks L. J., Clayton B. E., Lloyd R. S. Zinc and copper concentrations in leucocytes and erythrocytes in healthy adults and the effect of oral contraceptives. J Clin Pathol. 1983 Sep;36(9):1016–1021. doi: 10.1136/jcp.36.9.1016. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Hinks L. J., Colmsee M., Delves H. T. Determination of zinc and copper in isolated leucocytes. Analyst. 1982 Jul;107(1276):815–823. doi: 10.1039/an9820700815. [DOI] [PubMed] [Google Scholar]
- Jones R. Genital herpes and zinc. Med J Aust. 1979 Apr 7;1(7):286–286. doi: 10.5694/j.1326-5377.1979.tb112105.x. [DOI] [PubMed] [Google Scholar]
- Meadows N. J., Ruse W., Smith M. F., Day J., Keeling P. W., Scopes J. W., Thompson R. P., Bloxam D. L. Zinc and small babies. Lancet. 1981 Nov 21;2(8256):1135–1137. doi: 10.1016/s0140-6736(81)90587-0. [DOI] [PubMed] [Google Scholar]
- Meech R. J., Smith J. M., Chew T. Pathogenic mechanisms in recurrent genital candidosis in women. N Z Med J. 1985 Jan 23;98(771):1–5. [PubMed] [Google Scholar]
- Meret S., Henkin R. I. Simultaneous direct estimation by atomic absorption spectrophotometry of copper and zinc in serum, urine, and cerebrospinal fluid. Clin Chem. 1971 May;17(5):369–373. [PubMed] [Google Scholar]
- Prasad A. S. Clinical, biochemical, and pharmacological role of zinc. Annu Rev Pharmacol Toxicol. 1979;19:393–426. doi: 10.1146/annurev.pa.19.040179.002141. [DOI] [PubMed] [Google Scholar]
- Truswell A. S. ABC of nutrition. Measuring nutrition. Br Med J (Clin Res Ed) 1985 Nov 2;291(6504):1258–1262. doi: 10.1136/bmj.291.6504.1258. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Willmott F., Say J., Downey D., Hookham A. Zinc and recalcitrant trichomoniasis. Lancet. 1983 May 7;1(8332):1053–1053. doi: 10.1016/s0140-6736(83)92684-3. [DOI] [PubMed] [Google Scholar]