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. 1987 Oct;63(5):305–308. doi: 10.1136/sti.63.5.305

Chromosomally mediated intrinsic resistance to penicillin of penicillinase producing strains of Neisseria gonorrhoeae isolated in Sydney: guide to treatment with Augmentin.

J W Tapsall 1, E A Phillips 1, L M Morris 1
PMCID: PMC1194097  PMID: 3119461

Abstract

Single dose Augmentin treatment fails to cure an appreciable proportion of patients infected with penicillinase producing Neisseria gonorrhoeae (PPNG) strains in parts of the world where high levels of chromosomally mediated intrinsic resistance are also present in gonococci. The levels of intrinsic resistance to penicillin of 31 PPNG strains isolated in Sydney were assessed by obtaining beta lactamase negative variants of these strains and measuring the minimum inhibitory concentration of penicillin by agar plate dilution techniques. The levels of intrinsic resistance found in these imported PPNG strains were higher than those recorded for local isolates of non-PPNG strains, which indicates that caution should be exercised in the use of single dose Augmentin treatment of infections with PPNG strains in Sydney.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Cody R. M. Preservation and storage of pathogenic Neisseria. Health Lab Sci. 1978 Oct;15(4):206–209. [PubMed] [Google Scholar]
  2. Jaffe H. W., Biddle J. W., Thornsberry C., Johnson R. E., Kaufman R. E., Reynolds G. H., Wiesner P. J. National gonorrhea therapy monitoring study: in vitro antibiotic susceptibility and its correlation with treatment results. N Engl J Med. 1976 Jan 1;294(1):5–9. doi: 10.1056/NEJM197601012940102. [DOI] [PubMed] [Google Scholar]
  3. Key P. R., Azadian B. S., Evans B. A. Augmentin compared with amoxycillin in treating uncomplicated gonorrhoea. Genitourin Med. 1985 Jun;61(3):165–167. doi: 10.1136/sti.61.3.165. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Lawrence A. G., Shanson D. C. Single dose oral amoxycillin 3 g with either 125 mg or 250 mg clavulanic acid to treat uncomplicated anogenital gonorrhoea. Genitourin Med. 1985 Jun;61(3):168–171. doi: 10.1136/sti.61.3.168. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Lim K. B., Rajan V. S., Giam Y. C., Lui E. O., Sng E. H., Yeo K. L. Two dose Augmentin treatment of acute gonorrhoea in men. Br J Vener Dis. 1984 Jun;60(3):161–163. doi: 10.1136/sti.60.3.161. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Lim K. B., Thirumoorthy T., Lee C. T., Sng E. H., Tan T. Three regimens of procaine penicillin G, Augmentin, and probenecid compared for treating acute gonorrhoea in men. Genitourin Med. 1986 Apr;62(2):82–85. doi: 10.1136/sti.62.2.82. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Miller J. M., Baker C. N., Thornsberry C. Inhibition of beta-lactamase in Neisseria gonorrhoeae by sodium clavulanate. Antimicrob Agents Chemother. 1978 Nov;14(5):794–796. doi: 10.1128/aac.14.5.794. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Reading C., Cole M. Clavulanic acid: a beta-lactamase-inhiting beta-lactam from Streptomyces clavuligerus. Antimicrob Agents Chemother. 1977 May;11(5):852–857. doi: 10.1128/aac.11.5.852. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Tapsall J. W., Cheng J. K. Rapid identification of pathogenic species of Neisseria by carbohydrate degradation tests. Importance of glucose in media used for preparation of inocula. Br J Vener Dis. 1981 Aug;57(4):249–252. doi: 10.1136/sti.57.4.249. [DOI] [PMC free article] [PubMed] [Google Scholar]

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