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. 1988 Aug;64(4):223–225. doi: 10.1136/sti.64.4.223

Penicillin concentrations in cerebrospinal fluid (CSF) during repository treatment regimen for syphilis.

P G van der Valk 1, E J Kraai 1, P C van Voorst Vader 1, H Haaxma-Reiche 1, J A Snijder 1
PMCID: PMC1194220  PMID: 3169752

Abstract

Penicillin concentrations in cerebrospinal fluid (CSF) were measured in 40 asymptomatic patients with syphilis, 10 of whom had neurosyphilis. The patients were treated with 2.4 MIU procaine penicillin a day intramuscularly in combination with 500 mg probenecid every six hours orally. This intramuscular treatment regimen did not consistently yield treponemicidal penicillin concentrations in the CSF (subtreponemicidal CSF concentrations were found in 17 patients, four of whom had neurosyphilis). These data provide additional evidence that the cure of asymptomatic neurosyphilis is not guaranteed by intramuscular penicillin treatment.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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