Abstract
A rare case of verruciform xanthoma of the vulva is reported. Diagnosis was made possible by histopathological examination and immunohistochemical staining. Verruciform xanthomas generally occur in the oral cavity. To the best of our knowledge, this is the third reported case of the tumour located on the genital mucosa. Immunohistochemical study supported the histiocytic origin of the lesion. Clinically, verruciform xanthomas may mimic other verrucous lesions of the vulva, such as seborrhoeic keratosis, verruca simplex, condyloma acuminatum, verrucous carcinoma, or erythropasia of Queyrat, or conditions such as histiocytosis, cutaneous lipidosis, or granular cell myoblastoma. The characteristics that differentiate those conditions from verruciform xanthoma, which can be seen only on histology, are given.
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- Al-Nafussi A. I., Azzopardi J. G., Salm R. Verruciform xanthoma of the skin. Histopathology. 1985 Feb;9(2):245–252. doi: 10.1111/j.1365-2559.1985.tb02439.x. [DOI] [PubMed] [Google Scholar]
- Cobb C. M., Holt R., Denys F. R. Ultrastructural features of the verruciform xanthoma. J Oral Pathol. 1976 Jan;5(1):42–51. doi: 10.1111/j.1600-0714.1976.tb01756.x. [DOI] [PubMed] [Google Scholar]
- Kraemer B. B., Schmidt W. A., Foucar E., Rosen T. Verruciform xanthoma of the penis. Arch Dermatol. 1981 Aug;117(8):516–518. [PubMed] [Google Scholar]
- Ronan S. G., Bolano J., Manaligod J. R. Verruciform xanthoma of penis. Light and electron-microscopic study. Urology. 1984 Jun;23(6):600–603. doi: 10.1016/0090-4295(84)90082-7. [DOI] [PubMed] [Google Scholar]
- Santa Cruz D. J., Martin S. A. Verruciform xanthoma of the vulva. Report of two cases. Am J Clin Pathol. 1979 Feb;71(2):224–228. doi: 10.1093/ajcp/71.2.224. [DOI] [PubMed] [Google Scholar]
- Shafer W. G. Verruciform xanthoma. Oral Surg Oral Med Oral Pathol. 1971 Jun;31(6):784–789. doi: 10.1016/0030-4220(71)90134-4. [DOI] [PubMed] [Google Scholar]
- Zegarelli D. J., Aegarelli-Schmidt E. C., Zegarelli E. V. Verruciform xanthoma. A clinical, light microscopic, and electron microscopic study of two cases. Oral Surg Oral Med Oral Pathol. 1974 Nov;38(5):725–734. doi: 10.1016/0030-4220(74)90393-4. [DOI] [PubMed] [Google Scholar]