Abstract
Chlamydia trachomatis was sought at first and subsequent clinic visits in urethral swabs and urines from 112 heterosexual men with acute non-gonococcal urethritis (NGU). In comparison with a urethral swab tested by Micro Trak (MT), a urine deposit tested in the same way was 90% as sensitive. Examining a urine deposit by the enzyme immunoassay IDEIA was a little less sensitive (89%) than examining a similar deposit by MT, and was less sensitive (82%) than examining a urethral swab by MT. The results of testing urines were little influenced by collecting them either before or after swabbing the urethra, and there was evidence that examining all of a urine sample by IDEIA would have increased sensitivity. Overall, 55 (49%) of the men were diagnosed as C trachomatis-positive based on the results of testing both a urethral swab and a urine sample. Furthermore, a small numbers of chlamydiae were detected by examining urine by MT and, to a lesser extent, by IDEIA, so that there is no reason why this non-invasive approach should not be successful in men other than those with acute NGU.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Caul E. O., Paul I. D., Milne J. D., Crowley T. Non-invasive sampling method for detecting Chlamydia trachomatis. Lancet. 1988 Nov 26;2(8622):1246–1247. doi: 10.1016/s0140-6736(88)90831-8. [DOI] [PubMed] [Google Scholar]
- Paul I. D., Caul E. O. Evaluation of three Chlamydia trachomatis immunoassays with an unbiased, noninvasive clinical sample. J Clin Microbiol. 1990 Feb;28(2):220–222. doi: 10.1128/jcm.28.2.220-222.1990. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Smith T. F., Weed L. A. Comparison of urethral swabs, urine, and urinary sediment for the isolation of Chlamydia. J Clin Microbiol. 1976 Aug;2(2):134–135. [PMC free article] [PubMed] [Google Scholar]
- Taylor-Robinson D., Thomas B. J., Osborn M. F. Evaluation of enzyme immunoassay (Chlamydiazyme) for detecting Chlamydia trachomatis in genital tract specimens. J Clin Pathol. 1987 Feb;40(2):194–199. doi: 10.1136/jcp.40.2.194. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Taylor-Robinson D., Tuffrey M. Comparison of detection procedures for Chlamydia trachomatis, including enzyme immunoassays, in a mouse model of genital infection. J Med Microbiol. 1987 Sep;24(2):169–173. doi: 10.1099/00222615-24-2-169. [DOI] [PubMed] [Google Scholar]
- Thomas B. J., Evans R. T., Hawkins D. A., Taylor-Robinson D. Sensitivity of detecting Chlamydia trachomatis elementary bodies in smears by use of a fluorescein labelled monoclonal antibody: comparison with conventional chlamydial isolation. J Clin Pathol. 1984 Jul;37(7):812–816. doi: 10.1136/jcp.37.7.812. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Thomas B. J., Osborn M. F., Gilchrist C., Taylor-Robinson D. Improved sensitivity of an enzyme immunoassay IDEIA for detecting Chlamydia trachomatis. J Clin Pathol. 1989 Jul;42(7):759–762. doi: 10.1136/jcp.42.7.759. [DOI] [PMC free article] [PubMed] [Google Scholar]