Abstract
AIM--The aim of this study was to observe the changes in gonococcal serovar pattern in homosexual men over a 5 year period. METHODS--All men who presented to the Genitourinary Medicine clinic at Edinburgh Royal Infirmary between 1986 and 1990 with homosexually acquired gonococcal infection were included in the study. Gonococcal isolates were serotyped and the temporal change in isolated serovars noted. RESULTS--Over the 5 year period 32 different serovars were associated with 175 homosexually acquired infections. There was a dynamic temporal change in the dominant serovars with a continual influx of new strains some of which become established in the community but most of which appeared only transiently. Rapid variation in incidence over time was observed for certain serovars while others remained at more constant levels. There was a marked association between certain serovars (Ae/Av; Back/Bropyt; Bacejk/Brpyut; Bacejk/Brpyust; Baejk/Brpyut) and homosexually acquired infection. CONCLUSIONS--Possible determinants for the patterns observed are discussed but the underlying mechanism is probably multifactorial.
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Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Coghill D. V., Young H. Serological classification of Neisseria gonorrhoeae with monoclonal antibody coagglutination reagents. Genitourin Med. 1987 Aug;63(4):225–232. doi: 10.1136/sti.63.4.225. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Jacobson M. S. Cholesterol oxides in Indian ghee: possible cause of unexplained high risk of atherosclerosis in Indian immigrant populations. Lancet. 1987 Sep 19;2(8560):656–658. doi: 10.1016/s0140-6736(87)92443-3. [DOI] [PubMed] [Google Scholar]
- Knapp J. S., Holmes K. K., Bonin P., Hook E. W., 3rd Epidemiology of gonorrhea: distribution and temporal changes in auxotype/serovar classes of Neisseria gonorrhoeae. Sex Transm Dis. 1987 Jan-Mar;14(1):26–32. [PubMed] [Google Scholar]
- Morse S. A., Lysko P. G., McFarland L., Knapp J. S., Sandstrom E., Critchlow C., Holmes K. K. Gonococcal strains from homosexual men have outer membranes with reduced permeability to hydrophobic molecules. Infect Immun. 1982 Aug;37(2):432–438. doi: 10.1128/iai.37.2.432-438.1982. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Plummer F. A., Brunham R. C. Gonococcal recidivism, diversity, and ecology. Rev Infect Dis. 1987 Jul-Aug;9(4):846–850. doi: 10.1093/clinids/9.4.846. [DOI] [PubMed] [Google Scholar]
- Sarafian S. K., Knapp J. S. Molecular epidemiology of gonorrhea. Clin Microbiol Rev. 1989 Apr;2 (Suppl):S49–S55. doi: 10.1128/cmr.2.suppl.s49. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Tam M. R., Buchanan T. M., Sandström E. G., Holmes K. K., Knapp J. S., Siadak A. W., Nowinski R. C. Serological classification of Neisseria gonorrhoeae with monoclonal antibodies. Infect Immun. 1982 Jun;36(3):1042–1053. doi: 10.1128/iai.36.3.1042-1053.1982. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Woodford N., Bindayna K. M., Easmon C. S., Ison C. A. Associations between serotype and susceptibility to antibiotics of Neisseria gonorrhoeae. Genitourin Med. 1989 Apr;65(2):86–91. doi: 10.1136/sti.65.2.86. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Young H., Moyes A., Robertson D. H., McCartney A. C., Lindsay G., Gallacher G., Tait I. B., Brogan O., Fox C., Kohiyar G. A. Gonococcal infection within Scotland: antigenic heterogeneity and antibiotic susceptibility of infecting strains. Eur J Epidemiol. 1990 Mar;6(1):1–8. doi: 10.1007/BF00155541. [DOI] [PubMed] [Google Scholar]