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. 1992 Aug;68(4):260–262. doi: 10.1136/sti.68.4.260

Pefloxacin and ciprofloxacin in the treatment of uncomplicated gonococcal urethritis in males [corrected]

L L Cheong 1, R K Chan 1, M Nadarajah 1
PMCID: PMC1194886  PMID: 1328033

Abstract

OBJECTIVE--To study the effectiveness of single-dose pefloxacin and ciprofloxacin in the treatment of uncomplicated gonococcal urethritis in males. SETTING--Department of STD Control, Kelantan Road, Singapore. METHOD--160 male patients with uncomplicated gonococcal urethritis were assigned alternately to receive single oral doses of either pefloxacin 800 mg or ciprofloxacin 250 mg. RESULTS--Of the pefloxacin group 98.5% (65/66 patients) and of the ciprofloxacin group 98.6% (74/75 patients) were cured of gonorrhoea. The rates of post-gonococcal urethritis were 64.3% and 67.3% in the pefloxacin and ciprofloxacin groups, respectively. Both drugs were well tolerated and reported side-effects were minor and transient. There was a high incidence of penicillinase-producing gonococci (32.3%) and tetracycline resistant isolates with MIC > or = 2 mg/l (99.3%). High level tetracycline resistance (MIC > or = 16 mg/l) was found in 7.4% of isolates. CONCLUSION--The drugs in the dosages studied may be recommended for first-line treatment of uncomplicated gonococcal urethritis in males in Singapore. However, the emergence of bacterial resistance to the fluoroquinolones in the literature calls for vigilance in the monitoring of antimicrobial susceptibility [corrected].

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Ball M., Kanga J. M., Meilo H., Debeugny B. Treatment of acute gonococcal urethritis in men with a single dose of 800 mg pefloxacin. Br J Clin Pract. 1990 Apr;44(4):140–141. [PubMed] [Google Scholar]
  2. Brown S., Warnnissorn T., Biddle J., Panikabutra K., Traisupa A. Antimicrobial resistance of Neisseria gonorrhoea in Bangkok: is single-drug treatment passé. Lancet. 1982 Dec 18;2(8312):1366–1368. doi: 10.1016/s0140-6736(82)91271-5. [DOI] [PubMed] [Google Scholar]
  3. Bryan J. P., Hira S. K., Brady W., Luo N., Mwale C., Mpoko G., Krieg R., Siwiwaliondo E., Reichart C., Waters C. Oral ciprofloxacin versus ceftriaxone for the treatment of urethritis from resistant Neisseria gonorrhoeae in Zambia. Antimicrob Agents Chemother. 1990 May;34(5):819–822. doi: 10.1128/aac.34.5.819. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Faruki H., Kohmescher R. N., McKinney W. P., Sparling P. F. A community-based outbreak of infection with penicillin-resistant Neisseria gonorrhoeae not producing penicillinase (chromosomally mediated resistance). N Engl J Med. 1985 Sep 5;313(10):607–611. doi: 10.1056/NEJM198509053131004. [DOI] [PubMed] [Google Scholar]
  5. James D. G. Therapeutic focus. The fluoroquinolones. Br J Clin Pract. 1989 Feb;43(2):66–67. [PubMed] [Google Scholar]
  6. Jephcott A. E., Turner A. Ciprofloxacin resistance in gonococci. Lancet. 1990 Jan 20;335(8682):165–165. doi: 10.1016/0140-6736(90)90035-4. [DOI] [PubMed] [Google Scholar]
  7. Lassus A., Karppinen L., Ingervo L., Jeskanen L., Reitamo S., Happonen H. P., Karkulahti R. Ciprofloxacin versus amoxycillin and probenecid in the treatment of uncomplicated gonorrhoea. Scand J Infect Dis Suppl. 1989;60:58–61. [PubMed] [Google Scholar]
  8. Loo P. S., Ridgway G. L., Oriel J. D. Single dose ciprofloxacin for treating gonococcal infections in men. Genitourin Med. 1985 Oct;61(5):302–305. doi: 10.1136/sti.61.5.302. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Paton J. H., Reeves D. S. Fluoroquinolone antibiotics. Microbiology, pharmacokinetics and clinical use. Drugs. 1988 Aug;36(2):193–228. doi: 10.2165/00003495-198836020-00004. [DOI] [PubMed] [Google Scholar]
  10. Shahmanesh M., Shukla S. R., Phillips I., Westwood A., Thin R. N. Ciprofloxacin for treating urethral gonorrhoea in men. Genitourin Med. 1986 Apr;62(2):86–87. doi: 10.1136/sti.62.2.86. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Sng E. H., Lim A. L., Yeo K. L. Susceptibility to antimicrobials of Neisseria gonorrhoeae isolated in Singapore: implications on the need for more effective treatment regimens and control strategies. Br J Vener Dis. 1984 Dec;60(6):374–379. doi: 10.1136/sti.60.6.374. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Sng E. H., Rajan V. S., Pang R., Yeo K. L. Susceptibility of Neisseria gonorrhoeae to cefotaxime and ceftizoxime. Br J Vener Dis. 1981 Jun;57(3):162–164. doi: 10.1136/sti.57.3.162. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Turner A., Jephcott A. E., Haji T. C., Gupta P. C. Ciprofloxacin resistant Neisseria gonorrhoeae in the UK. Genitourin Med. 1990 Feb;66(1):43–43. doi: 10.1136/sti.66.1.43. [DOI] [PMC free article] [PubMed] [Google Scholar]

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