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. 1983 Aug;341:453–461. doi: 10.1113/jphysiol.1983.sp014816

Cyclic changes of plasma pancreatic polypeptide and pancreatic secretion in fasting dogs.

M H Chen, S N Joffe, D F Magee, R F Murphy, S Naruse
PMCID: PMC1195344  PMID: 6620187

Abstract

Fasting conscious dogs, each with a gastric fistula, Heidenhain pouch and Thomas duodenal fistula, were used. Basal pancreatic secretion showed periodic increases in phase with the periodic contraction of the stomach and duodenum. Periodic increases of plasma pancreatic polypeptide (PP), but not of gastrin, were observed in phase with the periodic contraction and secretion of the gut. Ganglion blockade abolished the cyclical activity, both secretory and motor, of the gut and of plasma PP. Intraduodenal infusion of lidocaine suppressed the spontaneous increase of pancreatic secretion and plasma PP. It is concluded both that the cyclical release of PP and the increase in pancreatic secretion are under the control of the intrinsic nerves of the duodenum.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Adrian T. E., Besterman H. S., Cooke T. J., Bloom S. R., Barnes A. J., Russell R. C. Mechanism of pancreatic polypeptide release in man. Lancet. 1977 Jan 22;1(8004):161–163. doi: 10.1016/s0140-6736(77)91762-7. [DOI] [PubMed] [Google Scholar]
  2. Boyes R. N., Adams H. J., Duce B. R. Oral absorption and disposition kinetics of lidocaine hydrochloride in dogs. J Pharmacol Exp Ther. 1970 Jul;174(1):1–8. [PubMed] [Google Scholar]
  3. Floyd J. C., Jr, Fajans S. S., Pek S., Chance R. E. A newly recognized pancreatic polypeptide; plasma levels in health and disease. Recent Prog Horm Res. 1976;33:519–570. doi: 10.1016/b978-0-12-571133-3.50019-2. [DOI] [PubMed] [Google Scholar]
  4. Gimmon Z., Murphy R. F., Chen M. H., Nachbauer C. A., Fischer J. E., Joffe S. N. The effect of parenteral and enteral nutrition on portal and systemic immunoreactivities of gastrin, glucagon and vasoactive intestinal polypeptide (VIP). Ann Surg. 1982 Nov;196(5):571–575. doi: 10.1097/00000658-198211000-00010. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Keane F. B., DiMagno E. P., Dozois R. R., Go V. L. Relationships among canine interdigestive exocrine pancreatic and biliary flow, duodenal motor activity, plasma pancreatic polypeptide, and motilin. Gastroenterology. 1980 Feb;78(2):310–316. [PubMed] [Google Scholar]
  6. Kulneff-Herlin A., Herlin P., Chen M. H., Gimmon Z., Murphy R. F., Joffe S. N. Circulating immunoreactivities of gastrin, glucagon and VIP after jejuno-ileal bypass. Peptides. 1982 Jan-Feb;3(1):91–93. doi: 10.1016/0196-9781(82)90148-6. [DOI] [PubMed] [Google Scholar]
  7. Lamers C. B., Diemel C. M., Jansen J. B. Serum pancreatic polypeptide responses to food and secretion in patients with Billroth I and Billroth II gastrectomies and in normal subjects. Surgery. 1982 Mar;91(3):288–292. [PubMed] [Google Scholar]
  8. Magee D. F., Nakajima S. The effects of antral acidification on the gastric secretion stimulated by endogenous and exogenous gastrin. J Physiol. 1968 Jun;196(3):713–721. doi: 10.1113/jphysiol.1968.sp008532. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Magee D. F., Naruse S. Effect of pancreatic juice on basal pancreatic and gastric secretion in dogs. J Physiol. 1982 Sep;330:489–496. doi: 10.1113/jphysiol.1982.sp014354. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Peeters T. L., Vantrappen G., Janssens J. Fasting plasma motilin levels are related to the interdigestive motility complex. Gastroenterology. 1980 Oct;79(4):716–719. [PubMed] [Google Scholar]
  11. Schwartz T. W., Rehfeld J. F., Stadil F., Larson L. I., Chance R. E., Moon N. Pancreatic-polypeptide response to food in duodenal-ulcer patients before and after vagotomy. Lancet. 1976 May 22;1(7969):1102–1105. doi: 10.1016/s0140-6736(76)90065-9. [DOI] [PubMed] [Google Scholar]
  12. Schwartz T. W., Stenquist B., Olbe L., Stadil F. Synchronous oscillations in the basal secretion of pancreatic-polypeptide and gastric acid. Depression by cholinergic blockade of pancreatic-polypeptide concentrations in plasma. Gastroenterology. 1979 Jan;76(1):14–19. [PubMed] [Google Scholar]
  13. Taylor I. L., Feldman M., Richardson C. T., Walsh J. H. Gastric and cephalic stimulation of human pancreatic polypeptide release. Gastroenterology. 1978 Sep;75(3):432–437. [PubMed] [Google Scholar]
  14. Taylor I. L., Impicciatore M., Carter D. C., Walsh J. H. Effect of atropine and vagotomy on pancreatic polypeptide response to a meal in dogs. Am J Physiol. 1978 Oct;235(4):E443–E447. doi: 10.1152/ajpendo.1978.235.4.E443. [DOI] [PubMed] [Google Scholar]
  15. Yamazaki Y. Inhibitory mechanism of oxethazaine on release of endogenous secretin and pancreatic response in dogs. Dig Dis Sci. 1982 Sep;27(9):821–827. doi: 10.1007/BF01391376. [DOI] [PubMed] [Google Scholar]

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