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. 1995 Apr;71(2):109–119. doi: 10.1136/sti.71.2.109

Arsphenamine jaundice and the recognition of instrument-borne virus infection.

P P Mortimer 1
PMCID: PMC1195466  PMID: 7744400

Abstract

Soon after its introduction in 1910, intravenous arsphenamine treatment for syphilis was found to be complicated by jaundice. The underlying cause, unsterile syringes and needles, was eventually recognised in the early 1940s, mainly through the efforts of British Army investigators. The infection most often transmitted was probably hepatitis B virus (HBV), but the high mortality in a few of the outbreaks of arsphenamine jaundice suggests that variants of HBV, or other hepatitis viruses, were sometimes involved. Fifty years later, at a time when there are estimated to be over three hundred million carriers of HBV in the world and probably at least as many hepatitis C virus carriers, and when the World Health Organisation estimates that there have been 17 million infections with human immunodeficiency virus, the lessons learnt around 1945 about the need to use sterile instruments and needles for all injections and venepunctures remain highly pertinent.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Barker L. F., Murray R. Relationship of virus dose to incubation time of clinical hepatitis and time of appearance of hepatitis--associated antigen. Am J Med Sci. 1972 Jan;263(1):27–33. doi: 10.1097/00000441-197201000-00005. [DOI] [PubMed] [Google Scholar]
  2. Bobkov A., Garaev M. M., Rzhaninova A., Kaleebu P., Pitman R., Weber J. N., Cheingsong-Popov R. Molecular epidemiology of HIV-1 in the former Soviet Union: analysis of env V3 sequences and their correlation with epidemiologic data. AIDS. 1994 May;8(5):619–624. [PubMed] [Google Scholar]
  3. Cossart Y. E., Vahrman J. Studies of Australia-SH antigen in sporadic viral hepatitis in London. Br Med J. 1970 Feb 14;1(5693):403–405. doi: 10.1136/bmj.1.5693.403. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. ELLIS F. P. Infective hepatitis and arsenotherapy hepatitis as it occurred amongst naval personnel in Portsmouth during the 1939-45 War. J Hyg (Lond) 1953 Jun;51(2):145–156. doi: 10.1017/s0022172400015588. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Gianotti F. Papular acrodermatitis of childhood. An Australia antigen disease. Arch Dis Child. 1973 Oct;48(10):794–799. doi: 10.1136/adc.48.10.794. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. HUGHES R. R. Post-penicillin jaundice. Br Med J. 1946 Nov 9;2(4479):685–688. doi: 10.1136/bmj.2.4479.685. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Hackett C. J. Private medical practice and anti-yaws campaigns in South Eastern Nigeria 1925-1950. Trop Doct. 1980 Jul;10(3):129–132. doi: 10.1177/004947558001000320. [DOI] [PubMed] [Google Scholar]
  8. Krugman S. Viral hepatitis: overview and historical perspectives. Yale J Biol Med. 1976 Jul;49(3):199–203. [PMC free article] [PubMed] [Google Scholar]
  9. Liang T. J., Hasegawa K., Munoz S. J., Shapiro C. N., Yoffe B., McMahon B. J., Feng C., Bei H., Alter M. J., Dienstag J. L. Hepatitis B virus precore mutation and fulminant hepatitis in the United States. A polymerase chain reaction-based assay for the detection of specific mutation. J Clin Invest. 1994 Feb;93(2):550–555. doi: 10.1172/JCI117006. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. McNEE J. Infective hepatitis: a problem of world health. Br Med J. 1952 Jun 28;1(4773):1367–1371. doi: 10.1136/bmj.1.4773.1367. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Mendelssohn K., Witts L. J. Transmission of Infection during Withdrawal of Blood. Br Med J. 1945 May 5;1(4400):625–626. doi: 10.1136/bmj.1.4400.625. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Oren I., Hershow R. C., Ben-Porath E., Krivoy N., Goldstein N., Rishpon S., Shouval D., Hadler S. C., Alter M. J., Maynard J. E. A common-source outbreak of fulminant hepatitis B in a hospital. Ann Intern Med. 1989 May 1;110(9):691–698. doi: 10.7326/0003-4819-110-9-691. [DOI] [PubMed] [Google Scholar]
  13. Patrascu I. V., Dumitrescu O. The epidemic of human immunodeficiency virus infection in Romanian children. AIDS Res Hum Retroviruses. 1993 Jan;9(1):99–104. doi: 10.1089/aid.1993.9.99. [DOI] [PubMed] [Google Scholar]
  14. Seeff L. B., Beebe G. W., Hoofnagle J. H., Norman J. E., Buskell-Bales Z., Waggoner J. G., Kaplowitz N., Koff R. S., Petrini J. L., Jr, Schiff E. R. A serologic follow-up of the 1942 epidemic of post-vaccination hepatitis in the United States Army. N Engl J Med. 1987 Apr 16;316(16):965–970. doi: 10.1056/NEJM198704163161601. [DOI] [PubMed] [Google Scholar]
  15. van den Hoek J. A., van Haastrecht H. J., Goudsmit J., de Wolf F., Coutinho R. A. Prevalence, incidence, and risk factors of hepatitis C virus infection among drug users in Amsterdam. J Infect Dis. 1990 Oct;162(4):823–826. doi: 10.1093/infdis/162.4.823. [DOI] [PubMed] [Google Scholar]

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