Skip to main content
Genitourinary Medicine logoLink to Genitourinary Medicine
. 1996 Jun;72(3):160–171. doi: 10.1136/sti.72.3.160

Sexually transmitted diseases in South Africa.

G B Pham-Kanter 1, M H Steinberg 1, R C Ballard 1
PMCID: PMC1195643  PMID: 8707316

Abstract

AIM: To review the epidemiology of and data collection for sexually transmitted diseases (STDs) in South Africa. METHODS: Literature published since 1980 on STDs in South Africa were complied and evaluated. Historical reports and salient unpublished literature were also used in the literature review. Studies were critically reviewed in the light of sample populations and study methods, and a baseline picture of the patterns of STD burden was developed. RESULTS: The STD burden in apparently asymptomatic study populations is significant. Ulcerative infections, primarily caused by syphilis and chancroid, are present in 5-15% of asymptomatic clinic attenders; prevalence rates of gonorrhoea average 8%, with up to 13% of gonococcal isolates resistant to penicillin antibiotics. In addition, on average, chlamydia and vaginal infections are detected in 16% and 20-49%, respectively, of antenatal and family planning clinic attenders. HIV seroprevalence rates have reached 7.6% in antenatal clinic attenders. Most South African STD data are derived from ad hoc surveys which have traditionally focused only on several major infections and particular urban centres. Almost all STD studies have been facility-based, with many studies based at STD clinics, thus reporting only relative frequencies and not population-based prevalences of STDs. With the possible exception of HIV, systematic surveillance data for STDs are conspicuously lacking. CONCLUSION: The disease burden of classic sexually transmitted infections has historically been heavy, and continues to be a serious public health problem in South Africa. Morbidity from both ulcerative and non-ulcerative infections, particularly in women, is significant. The body of STD data, although mostly sound, remains incomplete, and with the rapid emergence of HIV in South Africa, surveillance of STDs and focused STD policies will be critical.

Full text

PDF
160

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Allen L. A., Schoon M. G. Diagnostic laparoscopy and management of patients with confirmed acute pelvic inflammatory disease. S Afr Med J. 1984 Feb 11;65(6):201–202. [PubMed] [Google Scholar]
  2. Ballot D. E., Rothberg A. D. Congenital syphilis as a notifiable disease. S Afr Med J. 1993 Oct;83(10):721–723. [PubMed] [Google Scholar]
  3. Bam R. H., Cronjé H. S., Muir A., Griessel D. J., Hoek B. B. Syphilis in pregnant patients and their offspring. Int J Gynaecol Obstet. 1994 Feb;44(2):113–118. doi: 10.1016/0020-7292(94)90063-9. [DOI] [PubMed] [Google Scholar]
  4. Barnes R. C., Holmes K. K. Epidemiology of gonorrhea: current perspectives. Epidemiol Rev. 1984;6:1–30. doi: 10.1093/oxfordjournals.epirev.a036267. [DOI] [PubMed] [Google Scholar]
  5. Bassa A. G., Hoosen A. A., Moodley J., Bramdev A. Granuloma inguinale (donovanosis) in women. An analysis of 61 cases from Durban, South Africa. Sex Transm Dis. 1993 May-Jun;20(3):164–167. [PubMed] [Google Scholar]
  6. Bilgeri Y. R., Ballard R. C., Duncan M. O., Mauff A. C., Koornhof H. J. Antimicrobial susceptibility of 103 strains of Haemophilus ducreyi isolated in Johannesburg. Antimicrob Agents Chemother. 1982 Oct;22(4):686–688. doi: 10.1128/aac.22.4.686. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Bloch B., Dehaeck C. M. Human papillomavirus and the squamous epithelium of the female genital tract. S Afr Med J. 1987 Oct 17;72(8):557–558. [PubMed] [Google Scholar]
  8. Burchell H. J., Cronjé H. S., de Wet J. I. Efficacy of different antibiotics in the treatment of pelvic inflammatory disease. S Afr Med J. 1987 Aug 15;72(4):248–249. [PubMed] [Google Scholar]
  9. Cameron D. W., Simonsen J. N., D'Costa L. J., Ronald A. R., Maitha G. M., Gakinya M. N., Cheang M., Ndinya-Achola J. O., Piot P., Brunham R. C. Female to male transmission of human immunodeficiency virus type 1: risk factors for seroconversion in men. Lancet. 1989 Aug 19;2(8660):403–407. doi: 10.1016/s0140-6736(89)90589-8. [DOI] [PubMed] [Google Scholar]
  10. Cooper K., Herrington C. S., Graham A. K., Evans M. F., McGee J. O. In situ human papillomavirus (HPV) genotyping of cervical intraepithelial neoplasia in South African and British patients: evidence for putative HPV integration in vivo. J Clin Pathol. 1991 May;44(5):400–405. doi: 10.1136/jcp.44.5.400. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Cooper K., Herrington C. S., Lo E. S., Evans M. F., McGee J. O. Integration of human papillomavirus types 16 and 18 in cervical adenocarcinoma. J Clin Pathol. 1992 May;45(5):382–384. doi: 10.1136/jcp.45.5.382. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Cooper K., McGee J. O. HPV genotypes in cervical neoplasia in South Africa. J Clin Pathol. 1992 Jan;45(1):90–90. doi: 10.1136/jcp.45.1.90-a. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Coovadia Y. M., Dada M. A., Kharsany A., Ramsaroop U., Bhamjee A. The emergence of penicillinase-producing strains of Neisseria gonorrhoeae in Durban. S Afr Med J. 1984 May 26;65(21):835–837. [PubMed] [Google Scholar]
  14. Coovadia Y. M., Kharsany A., Hoosen A. The microbial aetiology of genital ulcers in black men in Durban, South Africa. Genitourin Med. 1985 Aug;61(4):266–269. doi: 10.1136/sti.61.4.266. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. Coovadia Y. M., Kharsany A., Ramsaroop U. Antimicrobial susceptibility of Neisseria gonorrhoeae isolated in Durban, South Africa. Br J Vener Dis. 1984 Oct;60(5):306–308. doi: 10.1136/sti.60.5.306. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. Coovadia Y. M., Van den Ende J., Hoosen A. A., Kharsany A. Susceptibility of penicillinase-producing and non-penicillinase-producing strains of Neisseria gonorrhoeae isolated in Durban, South Africa, to 15 beta-lactam antibiotics. Sex Transm Dis. 1988 Jan-Mar;15(1):30–34. doi: 10.1097/00007435-198801000-00007. [DOI] [PubMed] [Google Scholar]
  17. Crewe-Brown H. H., Krige F. K., Davel G. H., Barron C., Van Vuuren J. A., Shipham S. O., Roux J. G. Genital ulceration in males at Ga-Rankuwa Hospital, Pretoria. S Afr Med J. 1982 Nov 27;62(23):861–863. [PubMed] [Google Scholar]
  18. Crewe-Brown H. H., Mahomed M. F., Pochee E., Shewan K. A., Adams A., Ebrahim O. Penicillinase producing strains of Neisseria gonorrhoeae in Pretoria. S Afr Med J. 1985 Feb 2;67(5):159–159. [PubMed] [Google Scholar]
  19. Cronje H. S., Joubert G., Muir A., Chapman R. D., Divall P., Bam R. H. Prevalence of vaginitis, syphilis and HIV infection in women in the Orange Free State. S Afr Med J. 1994 Sep;84(9):602–605. [PubMed] [Google Scholar]
  20. Dangor Y., Ballard R. C., da L Exposto F., Fehler G., Miller S. D., Koornhof H. J. Accuracy of clinical diagnosis of genital ulcer disease. Sex Transm Dis. 1990 Oct-Dec;17(4):184–189. doi: 10.1097/00007435-199010000-00007. [DOI] [PubMed] [Google Scholar]
  21. Dangor Y., Fehler G., Exposto F. D., Koornhof H. J. Causes and treatment of sexually acquired genital ulceration in southern Africa. S Afr Med J. 1989 Oct 7;76(7):339–341. [PubMed] [Google Scholar]
  22. Dangor Y., Miller S. D., Exposto F. da L., Koornhof H. J. Antimicrobial susceptibilities of southern African isolates of Haemophilus ducreyi. Antimicrob Agents Chemother. 1988 Sep;32(9):1458–1460. doi: 10.1128/aac.32.9.1458. [DOI] [PMC free article] [PubMed] [Google Scholar]
  23. Delport S. D. Congenital syphilis--a plea for prevention. S Afr Med J. 1988 Sep 17;74(6):311–311. [PubMed] [Google Scholar]
  24. Delport S. D., Rothberg A. D. Congenital syphilis--now a notifiable disease. S Afr Med J. 1992 Mar 21;81(6):288–289. [PubMed] [Google Scholar]
  25. Delport S. D. Serological screening of cord blood for syphilis. S Afr Med J. 1988 May 7;73(9):528–529. [PubMed] [Google Scholar]
  26. Dietrich M., Hoosen A. A., Moodley J., Moodley S. Urogenital tract infections in pregnancy at King Edward VIII Hospital, Durban, South Africa. Genitourin Med. 1992 Feb;68(1):39–41. doi: 10.1136/sti.68.1.39. [DOI] [PMC free article] [PubMed] [Google Scholar]
  27. Faber B. L. Donovanosis (granuloma inguinale) in the Orange Free State. S Afr Med J. 1987 Feb 7;71(3):196–196. [PubMed] [Google Scholar]
  28. Freinkel A. L., Counihan R. J. Granuloma inguinale (donovanosis) in South Africa. S Afr Med J. 1983 Apr 16;63(16):599–601. [PubMed] [Google Scholar]
  29. Freinkel A. L., Dangor Y., Koornhof H. J., Ballard R. C. A serological test for granuloma inguinale. Genitourin Med. 1992 Aug;68(4):269–272. doi: 10.1136/sti.68.4.269. [DOI] [PMC free article] [PubMed] [Google Scholar]
  30. Freinkel A. L. The enigma of granuloma inguinale in South Africa. S Afr Med J. 1990 Mar 17;77(6):301–303. [PubMed] [Google Scholar]
  31. Gonin J. M. Syphilis--an appraisal of the Groote Schuur Hospital antenatal screening programme. S Afr Med J. 1985 Jun 15;67(24):962–965. [PubMed] [Google Scholar]
  32. Hallett A. F., Appelbaum P. C., Cooper R., Mokgokong S., Monale D. Penicillinase-producing Neisseria gonorrhoeae from South Africa. Lancet. 1977 Jun 4;1(8023):1205–1205. doi: 10.1016/s0140-6736(77)92741-6. [DOI] [PubMed] [Google Scholar]
  33. Hayes L. J., Yearsley P., Treharne J. D., Ballard R. A., Fehler G. H., Ward M. E. Evidence for naturally occurring recombination in the gene encoding the major outer membrane protein of lymphogranuloma venereum isolates of Chlamydia trachomatis. Infect Immun. 1994 Dec;62(12):5659–5663. doi: 10.1128/iai.62.12.5659-5663.1994. [DOI] [PMC free article] [PubMed] [Google Scholar]
  34. Hoosen A. A., Quinlan D. J., Moodley J., Kharsany A. B., van den Ende J. Sexually transmitted pathogens in acute pelvic inflammatory disease. S Afr Med J. 1989 Sep 16;76(6):251–254. [PubMed] [Google Scholar]
  35. Hoosen A. A., Ross S. M., Mulla M. J., Patel M. The incidence of selected vaginal infections among pregnant urban blacks. S Afr Med J. 1981 May 30;59(23):827–829. [PubMed] [Google Scholar]
  36. Ison C. A., Roope N. S., Dangor Y., Radebe F., Ballard R. Antimicrobial susceptibilities and serotyping of Neisseria gonorrhoeae in southern Africa: influence of geographical source of infection. Epidemiol Infect. 1993 Apr;110(2):297–305. doi: 10.1017/s0950268800068230. [DOI] [PMC free article] [PubMed] [Google Scholar]
  37. Jennings O. G., Wiswedel K. Prevalence of Chlamydia trachomatis IgG and IgA antibody in gynaecology inpatients as determined by serum indirect immunoperoxidase assay. S Afr Med J. 1990 Mar 3;77(5):234–237. [PubMed] [Google Scholar]
  38. Johnson J. E., Dehaeck C. M., Soeters R., Williamson A. L. Typing and molecular characterization of human papillomaviruses in genital warts from South African women. J Med Virol. 1991 Jan;33(1):39–42. doi: 10.1002/jmv.1890330108. [DOI] [PubMed] [Google Scholar]
  39. Klugman K. P., Patel J., Sischy A., McIntyre J. A. Serological markers of sexually transmitted diseases associated with HIV-1 infection in pregnant black women. S Afr Med J. 1991 Sep 7;80(5):243–244. [PubMed] [Google Scholar]
  40. Laga M., Manoka A., Kivuvu M., Malele B., Tuliza M., Nzila N., Goeman J., Behets F., Batter V., Alary M. Non-ulcerative sexually transmitted diseases as risk factors for HIV-1 transmission in women: results from a cohort study. AIDS. 1993 Jan;7(1):95–102. doi: 10.1097/00002030-199301000-00015. [DOI] [PubMed] [Google Scholar]
  41. Learmonth G. M., Durcan C. M., Beck J. D. The changing incidence of cervical intra-epithelial neoplasia. S Afr Med J. 1990 Jun 16;77(12):637–639. [PubMed] [Google Scholar]
  42. Leiman G. Cervical cancer screening in a Johannesburg family planning centre. S Afr Med J. 1976 Apr 10;50(16):611–615. [PubMed] [Google Scholar]
  43. Liebowitz L. D., Ballard R. C., Koornhof H. J. In vitro susceptibility and cross-resistance of South African isolates of Neisseria gonorrhoeae to 14 antimicrobial agents. Antimicrob Agents Chemother. 1982 Oct;22(4):598–603. doi: 10.1128/aac.22.4.598. [DOI] [PMC free article] [PubMed] [Google Scholar]
  44. Lund R. J., Kibel M. A., Knight G. J., van der Elst C. Prophylaxis against gonococcal ophthalmia neonatorum. A prospective study. S Afr Med J. 1987 Nov 7;72(9):620–622. [PubMed] [Google Scholar]
  45. Manning B., Moodley J., Ross S. M. Syphilis in pregnant black women. S Afr Med J. 1985 Jun 15;67(24):966–967. [PubMed] [Google Scholar]
  46. Meiring J. A., Kemp E., Jennings D. L., Mdhlovu M., Koornhof H. J. High-level penicillin-resistant gonococcal infections in Port Elizabeth. S Afr Med J. 1989 Feb 4;75(3):118–119. [PubMed] [Google Scholar]
  47. Mlisana K. P., Monokoane S., Hoosen A. A., Moodley J., Adhikari M., Taylor L. Syphilis in the 'unbooked' pregnant woman. S Afr Med J. 1992 Jul;82(1):18–20. [PubMed] [Google Scholar]
  48. O'Farrell N., Hoosen A. A., Coetzee K. D., van den Ende J. Genital ulcer disease in women in Durban, South Africa. Genitourin Med. 1991 Aug;67(4):322–326. doi: 10.1136/sti.67.4.322. [DOI] [PMC free article] [PubMed] [Google Scholar]
  49. O'Farrell N., Hoosen A. A., Coetzee K. D., van den Ende J. Genital ulcer disease: accuracy of clinical diagnosis and strategies to improve control in Durban, South Africa. Genitourin Med. 1994 Feb;70(1):7–11. doi: 10.1136/sti.70.1.7. [DOI] [PMC free article] [PubMed] [Google Scholar]
  50. O'Farrell N., Hoosen A. A., Kharsany A. B., van den Ende J. Sexually transmitted pathogens in pregnant women in a rural South African community. Genitourin Med. 1989 Aug;65(4):276–280. doi: 10.1136/sti.65.4.276. [DOI] [PMC free article] [PubMed] [Google Scholar]
  51. O'Farrell N., Windsor I., Becker P. HIV-1 infection among heterosexual attenders at a sexually transmitted diseases clinic in Durban. S Afr Med J. 1991 Jul 6;80(1):17–20. [PubMed] [Google Scholar]
  52. Opai-Tetteh E. T., Hoosen A. A., Moodley J. Re-screening for syphilis at the time of delivery in areas of high prevalence. S Afr Med J. 1993 Oct;83(10):725–726. [PubMed] [Google Scholar]
  53. Plummer F. A., D'Costa L. J., Nsanze H., Dylewski J., Karasira P., Ronald A. R. Epidemiology of chancroid and Haemophilus ducreyi in Nairobi, Kenya. Lancet. 1983 Dec 3;2(8362):1293–1295. doi: 10.1016/s0140-6736(83)91161-3. [DOI] [PubMed] [Google Scholar]
  54. Ramphele M. A., Heap M. Health status of hostel dwellers. Part II. Infant mortality and prevalence of diabetes, hypertension and syphilis among adults. S Afr Med J. 1991 Jun 15;79(12):702–705. [PubMed] [Google Scholar]
  55. Rice R. J., Aral S. O., Blount J. H., Zaidi A. A. Gonorrhea in the United States 1975-1984: is the giant only sleeping? Sex Transm Dis. 1987 Apr-Jun;14(2):83–87. doi: 10.1097/00007435-198704000-00005. [DOI] [PubMed] [Google Scholar]
  56. Robins-Browne R. M., Gaillard M. C., Koornhof H. J., Mauff A. C. Penicillinase-producing Neisseria gonorrhoeae. S Afr Med J. 1977 Apr 23;51(17):568–568. [PubMed] [Google Scholar]
  57. Ross S. M., MacPherson T., Wallace J., Khatree M. H., Naeye R. L., Appelbaum P. C. Unsuccessful pregnancies--report on 200 perinatal postmortems. S Afr Med J. 1978 May 27;53(21):828–829. [PubMed] [Google Scholar]
  58. Ross S. M., Macpherson T. A., Naeye R. L., Khatree M. H., Wallace J. A. Causes of fetal and neonatal mortality in a South African black community. S Afr Med J. 1982 Jun 12;61(24):905–908. [PubMed] [Google Scholar]
  59. Rubin A. Vaginal discharge in the black pregnant patient: an evaluation of the relationship between symptomatology and diagnosis. S Afr Med J. 1980 Mar 15;57(11):404–406. [PubMed] [Google Scholar]
  60. Sischy A., da L'Exposto F., Dangor Y., Fehler H. G., Radebe F., Walkden D. D., Miller S. D., Ballard R. C. Syphilis serology in patients with primary syphilis and non-treponemal sexually transmitted diseases in southern Africa. Genitourin Med. 1991 Apr;67(2):129–132. doi: 10.1136/sti.67.2.129. [DOI] [PMC free article] [PubMed] [Google Scholar]
  61. Vink G., Moodley J. Gonorrhoea in black women attending a gynaecological outpatient department. S Afr Med J. 1980 Nov 29;58(22):901–902. [PubMed] [Google Scholar]
  62. Wasserheit J. N. Epidemiological synergy. Interrelationships between human immunodeficiency virus infection and other sexually transmitted diseases. Sex Transm Dis. 1992 Mar-Apr;19(2):61–77. [PubMed] [Google Scholar]
  63. Welgemoed N. C., Mahaffey A., Van den Ende J. Prevalence of Neisseria gonorrhoeae infection in patients attending an antenatal clinic. S Afr Med J. 1986 Jan 4;69(1):32–34. [PubMed] [Google Scholar]
  64. Williamson A. L., Dehaeck C. M., Soeters R. Typing of human papillomaviruses in cervical intraepithelial neoplasia grade 3 biopsies from Cape Town. J Med Virol. 1989 Jul;28(3):146–149. doi: 10.1002/jmv.1890280307. [DOI] [PubMed] [Google Scholar]
  65. Wistrand R., Wegerhoff F. Granuloma inguinale in the eastern Transvaal. S Afr Med J. 1985 Jan 5;67(1):13–15. [PubMed] [Google Scholar]
  66. Woods D. L., Draper R. R. A clinical assessment of stillborn infants. S Afr Med J. 1980 Mar 22;57(12):441–443. [PubMed] [Google Scholar]

Articles from Genitourinary Medicine are provided here courtesy of BMJ Publishing Group

RESOURCES