Abstract
Of 84 men with non-gonococcal urethritis (NGU), 24 yielded Chlamydia trachomatis by either cell culture or MicroTrak immunofluorescence test. All 84 were treated with bacampicillin 800 mg twice a day for seven days. Five (one chlamydia positive) defaulted from follow up 10 to 14 days after the start of treatment. Of the 23 chlamydia positive patients who attended follow up, 22 became chlamydia negative; 14 of the 23 patients also became asymptomatic and had normal urethral smears. Of the 56 chlamydia negative patients who attended follow up, 21 were cleared of their urethritis. Two patients reported side effects; one drowsiness and one mild diffuse alopecia. Bacampicillin may therefore be a safe and effective alternative to tetracycline or erythromycin in treating chlamydial urethritis in men.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Bergan T. Pharmacokinetic comparison of oral bacampicillin and parenteral ampicillin. Antimicrob Agents Chemother. 1978 Jun;13(6):971–974. doi: 10.1128/aac.13.6.971. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Bodin N. O., Ekström B., Forsgren U., Jalar L. P., Magni L., Ramsay C. H., Sjöberg B. Bacampicillin: a new orally well-absorbed derivative of ampicillin. Antimicrob Agents Chemother. 1975 Nov;8(5):518–525. doi: 10.1128/aac.8.5.518. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Bowie W. R., Alexander E. R., Holmes K. K. Eradication of Chlamydia trachomatis from the urethras of men with nongonococcal urethritis by treatment with amoxicillin. Sex Transm Dis. 1981 Apr-Jun;8(2):79–81. doi: 10.1097/00007435-198104000-00010. [DOI] [PubMed] [Google Scholar]
- Bowie W. R., Yu J. S., Fawcett A., Jones H. D. Tetracycline in nongonococcal urethritis. Comparison of 2 g and 1 g daily for seven days. Br J Vener Dis. 1980 Oct;56(5):332–336. doi: 10.1136/sti.56.5.332. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Lim K. B., Lee C. T., Thirumoorthy T., Arora P. N., Tan T., Sng E. H. The microbiology of non-gonococcal urethritis (NGU) in Singapore. Ann Acad Med Singapore. 1985 Oct;14(4):686–688. [PubMed] [Google Scholar]
- Møller B. R., Cramers M., From E. Pivampicillin in treating genital infection with Chlamydia trachomatis. Genitourin Med. 1985 Aug;61(4):264–265. doi: 10.1136/sti.61.4.264. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Ridgway G. L., Owen J. M., Oriel J. D. The antimicrobial susceptibility of Chlamydia trachomatis in cell culture. Br J Vener Dis. 1978 Apr;54(2):103–106. doi: 10.1136/sti.54.2.103. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Romanowski B. Clinical evaluation of oral bacampicillin in the therapy of uncomplicated gonorrhea. Can J Public Health. 1985 Mar-Apr;76(2):98–100. [PubMed] [Google Scholar]
- Sjövall J., Magni L., Bergan T. Pharmacokinetics of bacampicillin compared with those of ampicillin, pivampicillin, and amoxycillin. Antimicrob Agents Chemother. 1978 Jan;13(1):90–96. doi: 10.1128/aac.13.1.90. [DOI] [PMC free article] [PubMed] [Google Scholar]