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. 2025 Apr 1;25:451. doi: 10.1186/s12879-025-10859-w

Correction: Efficacy and safety of polymyxin B sulfate versus colistin sulfate in ICU patients with nosocomial pneumonia caused by carbapenem-resistant Acinetobacter baumannii: a multicenter, propensity score-matched, real-world cohort study

Wei Bu 1,2, Chengyu Wang 1, Yuan Wu 3, Peng Zhang 4, Nengfang Zhang 5, Ying Han 6, Xiaona Xu 1, Sha Li 1, Yan Cai 1,
PMCID: PMC11963409  PMID: 40170156

Correction: BMC Infect Dis 25, 390 (2025)

https://doi.org/10.1186/s12879-025-10773-1

Following publication of the original article [1], we were notified of a few corrections needed to Fig. 2 and Table 3:

Table 3.

The clinical outcomes and adverse events of ICU patients receiving PMB or CS for CRAB-caused nosocomial pneumonia

Characteristics Before PSMa After PSM
Total (N = 232) PMB (n = 132) CS (n = 100) P value Total (N = 190) PMB (n = 95) CS (n = 95) P value
Clinical responses
Success 162(69.8%) 89(67.4%) 73(73.0%) 0.360 139(73.2%) 69(72.6%) 70(73.7%) 0.871
Failure 70(30.2%) 43(32.6%) 27(27.0%) 51(26.8%) 26 (27.4%) 25(26.3%)
Microbiological responses
Eradication 45(19.4%) 24(18.2%) 21(21.0%) 0.771 40(21.1%) 20 (21.1%) 20 (21.1%) 1.000
Suppression 119(51.3%) 67(50.8%) 52(52.0%) 100(52.6%) 50(52.6%) 50 (52.6%)
Failure 68(29.3%) 41(31.0%) 27(27.0%) 50(26.3%) 25(26.3%) 25 (26.3%)
Mortality
14-days 40(17.2%) 25(18.9%) 15(15.0%) 0.431 30(15.8%) 16 (16.8%) 14 (14.7%) 0.691
28-days 71(30.6%) 47(35.6%) 24(24.0%) 0.057 54(28.4%) 31 (32.6%) 23(24.2%) 0.198
Adverse events
Overall AKIb 54(23.3%) 35(26.5%) 19(19.0%) 0.180 45(23.7%) 27(28.4%) 18(18.9%) 0.125
 KDIGO 1 25(10.8%) 16(12.1%) 9(9.0%) 0.953 21(11.1%) 13(13.7%) 8(8.4%) 0.635
 KDIGO 2 15(6.8%) 10(7.6%) 5(5.0%) 14(7.4%) 9(9.5%) 5(5.3%)
 KDIGO 3 14(6.0%) 9(6.8%) 5(5.0%) 10(5.3%) 5(5.3%) 5(5.3%)
Hepatotoxicityc 36(15.5%) 24(18.2%) 12(12.0%) 0.198 24(12.6%) 13 (13.7%) 11(11.6%) 0.662
 Mild 23(9.9%) 14(10.6%) 9(9.0%) 0.325 18(9.5%) 9(9.5%) 9(9.5%) 0.487
 Moderate 8(3.5%) 6(4.6%) 2(2.0%) 6(3.2%) 4 (4.2%) 2 (2.1%)
 Severe 5(2.2%) 4(3.0%) 1(1.0%) 0(0.0%) 0(0.0%) 0(0.0%)
Dermal toxicityd 21(9.1%) 21(15.9%) 0(0.0%)  < 0.001 18(9.5%) 18 (18.9%) 0 (0.0%)  < 0.001

1. a. PSM, propensity score matching

2. b. According to the KDIGO criteria, staging of acute kidney injury(AKI) as follows: (i) stage 1, serum creatinine 1.5 to 1.9 times baseline or ≥ 0.3 mg/dl (≥ 26.5 µmol/l) increase; (ii) stage 2, serum creatinine 2.0 to 2.9 times baseline; (iii) stage 3, serum creatinine serum creatinine 3.0 times baseline or ≥ 4.0 mg/dl (≥ 353.6 µmol/l) increase or initiation of renal replacement therapy

3. c. DILI severity classifications: i) mild: alanine transaminase (ALT) ≥ 5 or alkaline phosphatase (ALP) ≥ 2 and Total bilirubin (TBL) < 2 upper limit of normal (ULN); ii) Moderate: ALT ≥ 5 or ALP ≥ 2 and TBL ≥ 2 ULN, or symptomatic hepatitis; iii) Severe: ALT ≥ 5 or ALP ≥ 2 and TBL ≥ 2 ULN, or symptomatic hepatitis and 1 of the following criteria: international normalized ratio (INR) ≥ 1.5; ascites and/or encephalopathy, disease duration < 26 weeks, and absence of underlying cirrhosis; Other organ failure due to DILI; iiii) Fetal/transplantation: death or liver transplantation due to DILI

4. d. 5 cases of skin rashes and 13 with skin pigmentation in the PMB cohort

5. Definition of skin hyperpigmentation: A disorder characterized by darkening of the skin due to excessive melanin deposition

-the labels "a" and "b" in Fig. 2 had been reversed;

-there was a discrepancy between the hepatotoxicity data presented in Table 3 and the descriptions in the main text

Originally published Table 3:

Corrected Table 3:

Table 3.

The clinical outcomes and adverse events of patients receiving PMB or CS for CRAB nosocomial pneumonia

Characteristics Before PSMa After PSM
Total (N = 232) PMB (n = 132) CS (n = 100) P value Total (N = 190) PMB (n = 95) CS (n = 95) P value
Clinical responses
 Success 162(69.8%) 89(67.4%) 73(73.0%) 0.360 139(73.2%) 69(72.6%) 70(73.7%) 0.871
 Failure 70(30.2%) 43(32.6%) 27(27.0%) 51(26.8%) 26 (27.4%) 25(26.3%)
Microbiological responses
 Eradication 45(19.4%) 24(18.2%) 21(21.0%) 0.771 40(21.1%) 20 (21.1%) 20 (21.1%) 1.000
 Suppression 119(51.3%) 67(50.8%) 52(52.0%) 100(52.6%) 50(52.6%) 50 (52.6%)
 Failure 68(29.3%) 41(31.0%) 27(27.0%) 50(26.3%) 25(26.3%) 25 (26.3%)
Mortality
 14-days 40(17.2%) 25(18.9%) 15(15.0%) 0.431 30(15.8%) 16 (16.8%) 14 (14.7%) 0.691
 28-days 71(30.6%) 47(35.6%) 24(24.0%) 0.057 54(28.4%) 31 (32.6%) 23(24.2%) 0.198
Adverse events
 Overall AKIb 54(23.3%) 35(26.5%) 19(19.0%) 0.180 45(23.7%) 27(28.4%) 18(18.9%) 0.125
 KDIGO 1 25(10.8%) 16(12.1%) 9(9.0%) 0.953 21(11.1%) 13(13.7%) 8(8.4%) 0.635
 KDIGO 2 15(6.8%) 10(7.6%) 5(5.0%) 14(7.4%) 9(9.5%) 5(5.3%)
 KDIGO 3 14(6.0%) 9(6.8%) 5(5.0%) 10(5.3%) 5(5.3%) 5(5.3%)
 Hepatotoxicityc 12(5.2%) 8(6.0%) 4(4.0%) 0.483 10(5.3%) 6 (6.4%) 4(4.3%) 0.516
 Mild 7(3.0%) 4(3.0%) 3(3.0%) 0.428 6(3.2%) 3(3.2%) 3(3.2%) 0.453
 Moderate 5(2.2%) 4(3.0%) 1(1.0%) 4(2.1%) 3 (3.2%) 1 (1.1%)
 Dermal toxicityd 21(9.1%) 21(15.9%) 0(0.0%)  < 0.001 18(9.5%) 18 (18.9%) 0 (0.0%)  < 0.001

a. PSM, propensity score matching

b. According to the KDIGO criteria, staging of acute kidney injury(AKI) as follows: i) stage 1, serum creatinine 1.5 to 1.9 times baseline or ≥ 0.3 mg/dl (≥ 26.5 μmol/l) increase; ii) stage 2, serum creatinine 2.0 to 2.9 times baseline; iii) stage 3, serum creatinine serum creatinine 3.0 times baseline or ≥ 4.0 mg/dl (≥ 353.6 μmol/l) increase or initiation of renal replacement therapy

c. DILI severity classifications: i)mild: alanine transaminase (ALT) ≥ 5 or alkaline phosphatase (ALP) ≥ 2 and Total bilirubin (TBL) < 2 upper limit of normal (ULN); ii)Moderate: ALT ≥ 5 or ALP ≥ 2 and TBL ≥ 2 ULN, or symptomatic hepatitis; iii) Severe: ALT ≥ 5 or ALP ≥ 2 and TBL ≥ 2 ULN, or symptomatic hepatitis and 1 of the following criteria: international normalized ratio (INR) ≥ 1.5; ascites and/or encephalopathy, disease duration < 26 weeks, and absence of underlying cirrhosis; Other organ failure due to DILI; iiii) Fetal/transplantation: death or liver transplantation due to DILI

d. 5 case of skin rashes and 13 with skin pigmentation in the PMB group

The original article has been corrected.

Reference

  • 1.Bu W, et al. Efficacy and safety of polymyxin B sulfate versus colistin sulfate in ICU patients with nosocomial pneumonia caused by carbapenem-resistant Acinetobacter baumannii: a multicenter, propensity score-matched, real-world cohort study. BMC Infect Dis. 2025;25:390. 10.1186/s12879-025-10773-1. [DOI] [PMC free article] [PubMed] [Google Scholar]

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