Correction: BMC Infect Dis 25, 390 (2025)
https://doi.org/10.1186/s12879-025-10773-1
Following publication of the original article [1], we were notified of a few corrections needed to Fig. 2 and Table 3:
Table 3.
The clinical outcomes and adverse events of ICU patients receiving PMB or CS for CRAB-caused nosocomial pneumonia
| Characteristics | Before PSMa | After PSM | ||||||
|---|---|---|---|---|---|---|---|---|
| Total (N = 232) | PMB (n = 132) | CS (n = 100) | P value | Total (N = 190) | PMB (n = 95) | CS (n = 95) | P value | |
| Clinical responses | ||||||||
| Success | 162(69.8%) | 89(67.4%) | 73(73.0%) | 0.360 | 139(73.2%) | 69(72.6%) | 70(73.7%) | 0.871 |
| Failure | 70(30.2%) | 43(32.6%) | 27(27.0%) | 51(26.8%) | 26 (27.4%) | 25(26.3%) | ||
| Microbiological responses | ||||||||
| Eradication | 45(19.4%) | 24(18.2%) | 21(21.0%) | 0.771 | 40(21.1%) | 20 (21.1%) | 20 (21.1%) | 1.000 |
| Suppression | 119(51.3%) | 67(50.8%) | 52(52.0%) | 100(52.6%) | 50(52.6%) | 50 (52.6%) | ||
| Failure | 68(29.3%) | 41(31.0%) | 27(27.0%) | 50(26.3%) | 25(26.3%) | 25 (26.3%) | ||
| Mortality | ||||||||
| 14-days | 40(17.2%) | 25(18.9%) | 15(15.0%) | 0.431 | 30(15.8%) | 16 (16.8%) | 14 (14.7%) | 0.691 |
| 28-days | 71(30.6%) | 47(35.6%) | 24(24.0%) | 0.057 | 54(28.4%) | 31 (32.6%) | 23(24.2%) | 0.198 |
| Adverse events | ||||||||
| Overall AKIb | 54(23.3%) | 35(26.5%) | 19(19.0%) | 0.180 | 45(23.7%) | 27(28.4%) | 18(18.9%) | 0.125 |
| KDIGO 1 | 25(10.8%) | 16(12.1%) | 9(9.0%) | 0.953 | 21(11.1%) | 13(13.7%) | 8(8.4%) | 0.635 |
| KDIGO 2 | 15(6.8%) | 10(7.6%) | 5(5.0%) | 14(7.4%) | 9(9.5%) | 5(5.3%) | ||
| KDIGO 3 | 14(6.0%) | 9(6.8%) | 5(5.0%) | 10(5.3%) | 5(5.3%) | 5(5.3%) | ||
| Hepatotoxicityc | 36(15.5%) | 24(18.2%) | 12(12.0%) | 0.198 | 24(12.6%) | 13 (13.7%) | 11(11.6%) | 0.662 |
| Mild | 23(9.9%) | 14(10.6%) | 9(9.0%) | 0.325 | 18(9.5%) | 9(9.5%) | 9(9.5%) | 0.487 |
| Moderate | 8(3.5%) | 6(4.6%) | 2(2.0%) | 6(3.2%) | 4 (4.2%) | 2 (2.1%) | ||
| Severe | 5(2.2%) | 4(3.0%) | 1(1.0%) | 0(0.0%) | 0(0.0%) | 0(0.0%) | ||
| Dermal toxicityd | 21(9.1%) | 21(15.9%) | 0(0.0%) | < 0.001 | 18(9.5%) | 18 (18.9%) | 0 (0.0%) | < 0.001 |
1. a. PSM, propensity score matching
2. b. According to the KDIGO criteria, staging of acute kidney injury(AKI) as follows: (i) stage 1, serum creatinine 1.5 to 1.9 times baseline or ≥ 0.3 mg/dl (≥ 26.5 µmol/l) increase; (ii) stage 2, serum creatinine 2.0 to 2.9 times baseline; (iii) stage 3, serum creatinine serum creatinine 3.0 times baseline or ≥ 4.0 mg/dl (≥ 353.6 µmol/l) increase or initiation of renal replacement therapy
3. c. DILI severity classifications: i) mild: alanine transaminase (ALT) ≥ 5 or alkaline phosphatase (ALP) ≥ 2 and Total bilirubin (TBL) < 2 upper limit of normal (ULN); ii) Moderate: ALT ≥ 5 or ALP ≥ 2 and TBL ≥ 2 ULN, or symptomatic hepatitis; iii) Severe: ALT ≥ 5 or ALP ≥ 2 and TBL ≥ 2 ULN, or symptomatic hepatitis and 1 of the following criteria: international normalized ratio (INR) ≥ 1.5; ascites and/or encephalopathy, disease duration < 26 weeks, and absence of underlying cirrhosis; Other organ failure due to DILI; iiii) Fetal/transplantation: death or liver transplantation due to DILI
4. d. 5 cases of skin rashes and 13 with skin pigmentation in the PMB cohort
5. Definition of skin hyperpigmentation: A disorder characterized by darkening of the skin due to excessive melanin deposition
-the labels "a" and "b" in Fig. 2 had been reversed;
-there was a discrepancy between the hepatotoxicity data presented in Table 3 and the descriptions in the main text
Originally published Table 3:
Corrected Table 3:
Table 3.
The clinical outcomes and adverse events of patients receiving PMB or CS for CRAB nosocomial pneumonia
| Characteristics | Before PSMa | After PSM | ||||||
|---|---|---|---|---|---|---|---|---|
| Total (N = 232) | PMB (n = 132) | CS (n = 100) | P value | Total (N = 190) | PMB (n = 95) | CS (n = 95) | P value | |
| Clinical responses | ||||||||
| Success | 162(69.8%) | 89(67.4%) | 73(73.0%) | 0.360 | 139(73.2%) | 69(72.6%) | 70(73.7%) | 0.871 |
| Failure | 70(30.2%) | 43(32.6%) | 27(27.0%) | 51(26.8%) | 26 (27.4%) | 25(26.3%) | ||
| Microbiological responses | ||||||||
| Eradication | 45(19.4%) | 24(18.2%) | 21(21.0%) | 0.771 | 40(21.1%) | 20 (21.1%) | 20 (21.1%) | 1.000 |
| Suppression | 119(51.3%) | 67(50.8%) | 52(52.0%) | 100(52.6%) | 50(52.6%) | 50 (52.6%) | ||
| Failure | 68(29.3%) | 41(31.0%) | 27(27.0%) | 50(26.3%) | 25(26.3%) | 25 (26.3%) | ||
| Mortality | ||||||||
| 14-days | 40(17.2%) | 25(18.9%) | 15(15.0%) | 0.431 | 30(15.8%) | 16 (16.8%) | 14 (14.7%) | 0.691 |
| 28-days | 71(30.6%) | 47(35.6%) | 24(24.0%) | 0.057 | 54(28.4%) | 31 (32.6%) | 23(24.2%) | 0.198 |
| Adverse events | ||||||||
| Overall AKIb | 54(23.3%) | 35(26.5%) | 19(19.0%) | 0.180 | 45(23.7%) | 27(28.4%) | 18(18.9%) | 0.125 |
| KDIGO 1 | 25(10.8%) | 16(12.1%) | 9(9.0%) | 0.953 | 21(11.1%) | 13(13.7%) | 8(8.4%) | 0.635 |
| KDIGO 2 | 15(6.8%) | 10(7.6%) | 5(5.0%) | 14(7.4%) | 9(9.5%) | 5(5.3%) | ||
| KDIGO 3 | 14(6.0%) | 9(6.8%) | 5(5.0%) | 10(5.3%) | 5(5.3%) | 5(5.3%) | ||
| Hepatotoxicityc | 12(5.2%) | 8(6.0%) | 4(4.0%) | 0.483 | 10(5.3%) | 6 (6.4%) | 4(4.3%) | 0.516 |
| Mild | 7(3.0%) | 4(3.0%) | 3(3.0%) | 0.428 | 6(3.2%) | 3(3.2%) | 3(3.2%) | 0.453 |
| Moderate | 5(2.2%) | 4(3.0%) | 1(1.0%) | 4(2.1%) | 3 (3.2%) | 1 (1.1%) | ||
| Dermal toxicityd | 21(9.1%) | 21(15.9%) | 0(0.0%) | < 0.001 | 18(9.5%) | 18 (18.9%) | 0 (0.0%) | < 0.001 |
a. PSM, propensity score matching
b. According to the KDIGO criteria, staging of acute kidney injury(AKI) as follows: i) stage 1, serum creatinine 1.5 to 1.9 times baseline or ≥ 0.3 mg/dl (≥ 26.5 μmol/l) increase; ii) stage 2, serum creatinine 2.0 to 2.9 times baseline; iii) stage 3, serum creatinine serum creatinine 3.0 times baseline or ≥ 4.0 mg/dl (≥ 353.6 μmol/l) increase or initiation of renal replacement therapy
c. DILI severity classifications: i)mild: alanine transaminase (ALT) ≥ 5 or alkaline phosphatase (ALP) ≥ 2 and Total bilirubin (TBL) < 2 upper limit of normal (ULN); ii)Moderate: ALT ≥ 5 or ALP ≥ 2 and TBL ≥ 2 ULN, or symptomatic hepatitis; iii) Severe: ALT ≥ 5 or ALP ≥ 2 and TBL ≥ 2 ULN, or symptomatic hepatitis and 1 of the following criteria: international normalized ratio (INR) ≥ 1.5; ascites and/or encephalopathy, disease duration < 26 weeks, and absence of underlying cirrhosis; Other organ failure due to DILI; iiii) Fetal/transplantation: death or liver transplantation due to DILI
d. 5 case of skin rashes and 13 with skin pigmentation in the PMB group
The original article has been corrected.
Reference
- 1.Bu W, et al. Efficacy and safety of polymyxin B sulfate versus colistin sulfate in ICU patients with nosocomial pneumonia caused by carbapenem-resistant Acinetobacter baumannii: a multicenter, propensity score-matched, real-world cohort study. BMC Infect Dis. 2025;25:390. 10.1186/s12879-025-10773-1. [DOI] [PMC free article] [PubMed] [Google Scholar]
