Skip to main content
The Journal of Physiology logoLink to The Journal of Physiology
. 1983 Jan;334:133–140. doi: 10.1113/jphysiol.1983.sp014484

The effect of a natriuretic atrial extract on renal haemodynamics and urinary excretion in anaesthetized rats.

H B Borenstein, W A Cupples, H Sonnenberg, A T Veress
PMCID: PMC1197304  PMID: 6864555

Abstract

1. An extract of cardiac atrial tissue, when injected intravenously into anaesthetized rats, caused a large and rapid increase in renal excretion of sodium chloride. 2. The renal response to atrial extract was associated with increases in total and medullary blood flow in the kidney, as measured by microsphere and albumin uptake methods, respectively. 3. The data suggest that these changes in renal haemodynamics may contribute to, but are unlikely to be the complete cause of, the natriuresis and chloriuresis following injection of atrial tissue extract.

Full text

PDF
133

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Aukland K. Methods for measuring renal blood flow: total flow and regional distribution. Annu Rev Physiol. 1980;42:543–555. doi: 10.1146/annurev.ph.42.030180.002551. [DOI] [PubMed] [Google Scholar]
  2. Brace R. A. Fitting straight lines to experimental data. Am J Physiol. 1977 Sep;233(3):R94–R99. doi: 10.1152/ajpregu.1977.233.3.R94. [DOI] [PubMed] [Google Scholar]
  3. Data J. L., Rane A., Gerkens J., Wilkinson G. R., Nies A. S., Branch R. A. The influence of indomethacin on the pharmacokinetics, diuretic response and hemodynamics of furosemide in the dog. J Pharmacol Exp Ther. 1978 Aug;206(2):431–438. [PubMed] [Google Scholar]
  4. De Bold A. J. Heart atria granularity effects of changes in water-electrolyte balance. Proc Soc Exp Biol Med. 1979 Sep;161(4):508–511. doi: 10.3181/00379727-161-40584. [DOI] [PubMed] [Google Scholar]
  5. Ishise S., Pegram B. L., Yamamoto J., Kitamura Y., Frohlich E. D. Reference sample microsphere method: cardiac output and blood flows in conscious rat. Am J Physiol. 1980 Oct;239(4):H443–H449. doi: 10.1152/ajpheart.1980.239.4.H443. [DOI] [PubMed] [Google Scholar]
  6. JAMIESON J. D., PALADE G. E. SPECIFIC GRANULES IN ATRIAL MUSCLE CELLS. J Cell Biol. 1964 Oct;23:151–172. doi: 10.1083/jcb.23.1.151. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. KISCH B. Electron microscopy of the atrium of the heart. I. Guinea pig. Exp Med Surg. 1956;14(2-3):99–112. [PubMed] [Google Scholar]
  8. Katz M. A., Blantz R. C., Rector F. C., Jr, Seldin D. W. Measurement of intrarenal blood flow. I. Analysis of microsphere method. Am J Physiol. 1971 Jun;220(6):1903–1913. doi: 10.1152/ajplegacy.1971.220.6.1903. [DOI] [PubMed] [Google Scholar]
  9. Lameire N., Vanholder R., Ringoir S., Leusen I. Role of medullary hemodynamics in the natriuresis of drug-induced renal vasodilation in the rat. Circ Res. 1980 Dec;47(6):839–844. doi: 10.1161/01.res.47.6.839. [DOI] [PubMed] [Google Scholar]
  10. Puschett J. B., Kuhrman M. A. Differential effects of diuretic agents on electrolyte excretion in the dog. Role of renal hemodynamics. Nephron. 1979;23(1):38–45. doi: 10.1159/000181604. [DOI] [PubMed] [Google Scholar]
  11. Solez K., Kramer E. C., Fox J. A., Heptinstall R. H. Medullary plasma flow and intravascular leukocyte accumulation in acute renal failure. Kidney Int. 1974 Jul;6(1):24–37. doi: 10.1038/ki.1974.74. [DOI] [PubMed] [Google Scholar]
  12. Sonnenberg H., Chong C. K., Veress A. T. Cardiac atrial factor--an endogenous diuretic? Can J Physiol Pharmacol. 1981 Dec;59(12):1278–1279. doi: 10.1139/y81-200. [DOI] [PubMed] [Google Scholar]
  13. Sonnenberg H., Veress A. T., Pearce J. W. Intrarenal hemodynamics in cross-circulated hypervolemic and isovolemic rats. Circ Res. 1977 Aug;41(2):238–242. doi: 10.1161/01.res.41.2.238. [DOI] [PubMed] [Google Scholar]
  14. Stein J. H., Mauk R. C., Boonjarern S., Ferris T. F. Differences in the effect of furosemide and chlorothiazide on the distribution of renal cortical blood flow in the dog. J Lab Clin Med. 1972 Jun;79(6):995–1003. [PubMed] [Google Scholar]
  15. Tsuchiya M., Walsh G. M., Frohlich E. D. Systemic hemodynamic effects of microspheres in conscious rats. Am J Physiol. 1977 Nov;233(5):H617–H621. doi: 10.1152/ajpheart.1977.233.5.H617. [DOI] [PubMed] [Google Scholar]

Articles from The Journal of Physiology are provided here courtesy of The Physiological Society

RESOURCES