Abstract
1. The extent of the excretion in the bile of the rat of benzene and 21 of its simple derivatives was studied. 2. Some 16 compounds of molecular weight less than 200, and including neutral molecules (benzene and toluene), aromatic acids, aromatic amines and phenols, were injected in solution intraperitoneally into biliary-cannulated rats. Metabolites in the bile were identified and estimated. The extent of biliary excretion of these compounds was low, i.e. 0–10% of the dose in 24hr., and most appeared in the bile mainly as conjugates. 3. The biliary excretion of six conjugates of molecular weight less than 300, including three glycine conjugates, one sulphate conjugate, one glucuronic acid conjugate and two acetyl derivatives, was low (less than 3% of the dose). 4. It is concluded that simple benzene derivatives of molecular weight less than about 300 are poorly excreted in rat bile.
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Selected References
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- Bridges J. W., Kibby M. R., Williams R. T. The structure of the glucuronide of sulphadimethoxine formed in man. Biochem J. 1965 Sep;96(3):829–836. doi: 10.1042/bj0960829. [DOI] [PMC free article] [PubMed] [Google Scholar]
- CHIRIGOS M. A., UDENFRIEND S. A simple fluorometric procedure for determining salicylic acid in biologic tissues. J Lab Clin Med. 1959 Nov;54:769–772. [PubMed] [Google Scholar]
- FLOCK E. V., BOLLMAN J. L. The effect of thiouracil on the metabolism of L-thyroxine. Biochem J. 1962 Sep;84:621–626. doi: 10.1042/bj0840621. [DOI] [PMC free article] [PubMed] [Google Scholar]
- GAFFNEY G. W., SCHREIER K., DIFERRANTE N., ALTMAN K. I. The quantitative determination of hippuric acid. J Biol Chem. 1954 Feb;206(2):695–698. [PubMed] [Google Scholar]
- HASLEWOOD G. A. Recent developments in our knowledge of bile salts. Physiol Rev. 1955 Jan;35(1):178–196. doi: 10.1152/physrev.1955.35.1.178. [DOI] [PubMed] [Google Scholar]
- KLATSKIN G. Bile pigment metabolism. Annu Rev Med. 1961;12:211–250. doi: 10.1146/annurev.me.12.020161.001235. [DOI] [PubMed] [Google Scholar]
- Millburn P., Smith R. L., Williams R. T. Biliary excretion of foreign compounds. Biphenyl, stilboestrol and phenolphthalein in the rat: molecular weight, polarity and metabolism as factors in biliary excretion. Biochem J. 1967 Dec;105(3):1275–1281. doi: 10.1042/bj1051275. [DOI] [PMC free article] [PubMed] [Google Scholar]
- SCHELINE R. R., SMITH R. L., WILLIAMS R. T. The metabolism of arylthioureas. II. The metabolism of 14C- and 35S- labelled 1-phenyl-2-thiourea and its derivatives. J Med Pharm Chem. 1961 Jul 1;4:109–135. doi: 10.1021/jm50017a009. [DOI] [PubMed] [Google Scholar]
- WILLIAMS R. T., MILLBURN P., SMITH R. L. THE INFLUENCE OF ENTEROHEPATIC CIRCULATION ON TOXICITY OF DRUGS. Ann N Y Acad Sci. 1965 Mar 12;123:110–124. doi: 10.1111/j.1749-6632.1965.tb12249.x. [DOI] [PubMed] [Google Scholar]
- Williams R. T. Studies in detoxication: 13. The biosynthesis of aminophenyl- and sulphonamidoaminophenylglucuronides in the rabbit and their action on haemoglobin in vitro. Biochem J. 1943 Sep;37(3):329–333. doi: 10.1042/bj0370329. [DOI] [PMC free article] [PubMed] [Google Scholar]