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. 1967 Dec;105(3):1301–1305. doi: 10.1042/bj1051301

Effect of alloxan-diabetes on multiple forms of hexokinase in adipose tissue and lung

Patricia McLean 1, J Brown 1, Eileen Walters 1, K Greenslade 1
PMCID: PMC1198455  PMID: 16742560

Abstract

Comparison has been made of the effect of alloxan-diabetes on the multiple forms of hexokinase (EC 2.7.1.1) in adipose tissue and lung. Types I and II hexokinase were distinguished in adipose tissue by their different stabilities to heat treatment, which made it possible to determine the activity of each form spectrophotometrically; additional confirmatory evidence was obtained from starch-gel electrophoresis. Type II hexokinase was markedly depressed in adipose tissue from alloxan-diabetic rats. Lung contained types I, II and III hexokinase, type I predominating. There was no significant change in the pattern of these multiple forms of hexokinase in lung from alloxan-diabetic rats. These results are discussed in relation to current ideas that the insulin-sensitivity of a tissue may be correlated with the content of type II hexokinase.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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