Skip to main content
NCBI home page
Biochemical Journal logoLink to Biochemical Journal
. 1968 Jan;106(1):203–209. doi: 10.1042/bj1060203

The utilization of some halogenated aromatic acids by Nocardia. Effects on the growth and enzyme induction

A Smith 1,*, E Karen Tranter 1, R B Cain 1
PMCID: PMC1198487  PMID: 5721458

Abstract

1. Halogen analogues of benzoate and p-nitrobenzoate did not support growth of Nocardia erythropolis. 2. These analogues, when present together with the parent compounds, inhibited growth of the organism. 3. The halogen analogues similarly inhibited oxidation of benzoate or p-nitrobenzoate by competent cells. 4. Fluoroacetate and 2-fluoro-4-nitrobenzoate caused comparable inhibition of growth on p-nitrobenzoate and both led to some citrate accumulation. 5. The induction of the p-nitrobenzoate-oxidation system was strongly inhibited by all the 2-halogeno-4-nitrobenzoates although the 2-fluoro and 2-chloro derivatives also acted as inducers. 6. Halogen analogues of benzoate also induced the benzoate-oxidation system.

Full text

PDF
203

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. BEHRMAN E. J., STANIER R. Y. The bacterial oxidation of nicotinic acid. J Biol Chem. 1957 Oct;228(2):923–945. [PubMed] [Google Scholar]
  2. BERNHEIM F. The effect of substituted benzoic acids on adaptive enzyme formation in a Mycobacterium. J Biol Chem. 1953 Aug;203(2):775–780. [PubMed] [Google Scholar]
  3. BIRNIE G. D., KROEGER H., HEIDELBERGER C. STUDIES OF FLUORINATED PYRIMIDINES. XVIII. THE DEGRADATION OF 5-FLUORO-2'-DEOXYURIDINE AND RELATED COMPOUNDS BY NUCLEOSIDE PHOSPHORYLASE. Biochemistry. 1963 May-Jun;2:566–572. doi: 10.1021/bi00903a031. [DOI] [PubMed] [Google Scholar]
  4. CAIN R. B. The microbial metabolism of nitro-aromatic compounds. J Gen Microbiol. 1958 Aug;19(1):1–14. doi: 10.1099/00221287-19-1-1. [DOI] [PubMed] [Google Scholar]
  5. CARTWRIGHT N. J., CAIN R. B. Bacterial degradation of the nitrobenzoic acids. Biochem J. 1959 Feb;71(2):248–261. doi: 10.1042/bj0710248. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Cain R. B., Tranter E. K., Darrah J. A. The utilization of some halogenated aromatic acids by Nocardia. Oxidation and metabolism. Biochem J. 1968 Jan;106(1):211–227. doi: 10.1042/bj1060211. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. EVANS W. C., SMITH B. S. The photochemical inactivation and microbial metabolism of the chlorophenoxyacetic acid herbicides. Biochem J. 1954 May 15;57(329TH):xxx–xxx. [PubMed] [Google Scholar]
  8. GESSNER T., SMITH J. N. Comparative detoxication. 8. The metabolism of chlorobenzene in locusts: phenolic metabolites, a comparison with some vertebrate species. Biochem J. 1960 Apr;75:172–179. doi: 10.1042/bj0750172. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. GOLDMAN P. THE ENZYMATIC CLEAVAGE OF THE CARBON-FLUORINE BOND IN FLUOROACETATE. J Biol Chem. 1965 Aug;240:3434–3438. [PubMed] [Google Scholar]
  10. HIRSCH P., ALEXANDER M. Microbial decomposition of halogenated propionic and acetic acids. Can J Microbiol. 1960 Jun;6:241–249. doi: 10.1139/m60-028. [DOI] [PubMed] [Google Scholar]
  11. HUGHES D. E. 6-Hydroxynicotinic acid as an intermediate in the oxidation of nicotinic acid by Pseudomonas fluorescens. Biochem J. 1955 Jun;60(2):303–310. doi: 10.1042/bj0600303. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. HUGHES D. E. THE METABOLISM OF HALOGEN-SUBSTITUTED BENZOIC ACIDS BY PSEUDOMONAS FLUORESCENS. Biochem J. 1965 Jul;96:181–188. doi: 10.1042/bj0960181. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. KAUFMAN S. The enzymic conversion of 4-fluorophenylalanine to tyrosine. Biochim Biophys Acta. 1961 Aug 19;51:619–621. doi: 10.1016/0006-3002(61)90632-1. [DOI] [PubMed] [Google Scholar]
  14. Kelly M. Isolation of bacteria able to metabolize fluoroacetate or fluoroacetamide. Nature. 1965 Nov 20;208(5012):809–810. doi: 10.1038/208809a0. [DOI] [PubMed] [Google Scholar]
  15. MORRISON J. F., PETERS R. A. Biochemistry of fluoroacetate poisoning: the effect of fluorocitrate on purified aconitase. Biochem J. 1954 Nov;58(3):473–479. doi: 10.1042/bj0580473. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. PETERS R. A. Lethal synthesis. Proc R Soc Lond B Biol Sci. 1952 Feb 28;139(895):143–170. doi: 10.1098/rspb.1952.0001. [DOI] [PubMed] [Google Scholar]
  17. PETERS R. A. Mechanism of the toxicity of the active constituent of Dichapetalum cymosum and related compounds. Adv Enzymol Relat Subj Biochem. 1957;18:113–159. doi: 10.1002/9780470122631.ch3. [DOI] [PubMed] [Google Scholar]
  18. RICHMOND M. H. Random replacement of phenylalanine by p-fluorophenylalanine in alkaline phosphatase(s) formed during biosynthesis by E. coli. J Mol Biol. 1963 Apr;6:284–294. doi: 10.1016/s0022-2836(63)80089-3. [DOI] [PubMed] [Google Scholar]
  19. STRAUSS B. S. The nature of the lesion in the succinate-requiring mutants of Neurospora crassa: interaction between carbohydrate and nitrogen metabolism. J Gen Microbiol. 1956 Jul;14(3):494–511. doi: 10.1099/00221287-14-3-494. [DOI] [PubMed] [Google Scholar]
  20. TAYLOR T. G. A modified procedure for the microdetermination of citric acid. Biochem J. 1953 Apr;54(1):48–49. doi: 10.1042/bj0540048. [DOI] [PMC free article] [PubMed] [Google Scholar]

Articles from Biochemical Journal are provided here courtesy of The Biochemical Society

RESOURCES