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. 1968 Jan;106(2):507–514. doi: 10.1042/bj1060507

Degradation of phenylalanine and tyrosine by Sporobolomyces roseus

Keith Moore 1,*, P V Subba Rao 1, G H N Towers 1
PMCID: PMC1198531  PMID: 5688927

Abstract

Ammonia-lyase activity for l-phenylalanine, m-hydroxyphenylalanine and l-tyrosine was demonstrated in cell-free extracts of Sporobolomyces roseus. Cultures of this organism converted dl-[ring-14C]phenylalanine and l-[U-14C]tyrosine into the corresponding cinnamic acid. Tracer studies showed that these compounds were further metabolized to [14C]protocatechuic acid. Benzoic acid and p-hydroxybenzoic acid were intermediates in this pathway. Washed cells of the organism readily utilized cinnamic acid, p-coumaric acid, caffeic acid, benzoic acid and p-hydroxybenzoic acid. Protocatechuic acid was the terminal aromatic compound formed during the metabolism of these compounds. The cells of S. roseus were able to convert m-coumaric acid into m-hydroxybenzoic acid, but the latter compound, which accumulated in the medium, was not further metabolized. 4-Hydroxycoumarin was identified as the product of o-coumaric acid metabolism by this organism.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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