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. 1984 Jan;346:461–469. doi: 10.1113/jphysiol.1984.sp015035

Neuronally mediated interactions between urinary bladder and internal anal sphincter motility in the cat.

M Bouvier, J C Grimaud
PMCID: PMC1199512  PMID: 6142106

Abstract

The effects of stimulation of vesical afferents on the electrical activity of the internal anal sphincter were studied in anaesthetized cats. Excitation of vesical afferents, either by electrical stimulation of nerves running at the vesico-ureteral junction or by bladder distension, produced (1) an increase in the electrical activity of the internal anal sphincter which was abolished by the alpha-blocker phentolamine (1.5 mg/kg, I.V.); (2) an inhibition of the excitatory response evoked in the internal anal sphincter by stimulation of one hypogastric nerve. This effect was blocked by naloxone (2 mg/kg, I.V.). These reflexes were abolished by hexamethonium (1 mg/kg, I.V.). Both reflexes were unaffected by section of sacral spinal roots (S1-S3) or by administration of atropine (0.1 mg/kg, I.V.). This excludes any participation of the parasympathetic nervous system. The excitatory and inhibitory reflexes were only slightly affected by section of the lumbar dorsal spinal roots (L1-L7) whereas they were strongly decreased after section of the corresponding ventral roots. The reflexes were abolished after section of the remaining hypogastric nerve. These results provide evidence for crossed reflexes between urinary bladder and internal anal sphincter which are achieved partly in the lumbar spinal cord and partly within the inferior mesenteric ganglion. Some of the vesical afferent nerve fibres responsible for these interactions presumably reach the spinal cord via the lumbar ventral spinal roots.

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Selected References

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  1. Bouvier M., Gonella J. Electrical activity from smooth muscle of the anal sphincteric area of the cat. J Physiol. 1981 Jan;310:445–456. doi: 10.1113/jphysiol.1981.sp013560. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Bouvier M., Gonella J. Nervous control of the internal anal sphincter of the cat. J Physiol. 1981 Jan;310:457–469. doi: 10.1113/jphysiol.1981.sp013561. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Clifton G. L., Coggeshall R. E., Vance W. H., Willis W. D. Receptive fields of unmyelinated ventral root afferent fibres in the cat. J Physiol. 1976 Apr;256(3):573–600. doi: 10.1113/jphysiol.1976.sp011340. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Coggeshall R. E., Applebaum M. L., Fazen M., Stubbs T. B., 3rd, Sykes M. T. Unmyelinated axons in human ventral roots, a possible explanation for the failure of dorsal rhizotomy to relieve pain. Brain. 1975 Mar;98(1):157–166. doi: 10.1093/brain/98.1.157. [DOI] [PubMed] [Google Scholar]
  5. Coggeshall R. E., Coulter J. D., Willis W. D., Jr Unmyelinated axons in the ventral roots of the cat lumbosacral enlargement. J Comp Neurol. 1974 Jan 1;153(1):39–58. doi: 10.1002/cne.901530105. [DOI] [PubMed] [Google Scholar]
  6. Crowcroft P. J., Holman M. E., Szurszewski J. H. Excitatory input from the distal colon to the inferior mesenteric ganglion in the guinea-pig. J Physiol. 1971 Dec;219(2):443–461. doi: 10.1113/jphysiol.1971.sp009671. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Dalsgaard C. J., Elfvin L. G. Structural studies on the connectivity of the inferior mesenteric ganglion of the guinea pig. J Auton Nerv Syst. 1982 May;5(3):265–278. doi: 10.1016/0165-1838(82)90070-4. [DOI] [PubMed] [Google Scholar]
  8. Floyd K., McMahon S. B., Morrison J. F. Inhibitory interactions between colonic and vesical afferents in the micturition reflex of the cat. J Physiol. 1982 Jan;322:45–52. doi: 10.1113/jphysiol.1982.sp014021. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Garrett J. R., Howard E. R., Jones W. The internal anal sphincter in the cat: a study of nervous mechanisms affecting tone and reflex activity. J Physiol. 1974 Nov;243(1):153–166. doi: 10.1113/jphysiol.1974.sp010747. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Gonella J. Modifications of electrical activity of the rabbit duodenum longitudinal muscle after contractions of the circular muscle. Am J Dig Dis. 1972 Apr;17(4):327–332. doi: 10.1007/BF02231733. [DOI] [PubMed] [Google Scholar]
  11. KOCK N. G., POMPEIUS R. INHIBITION OF VESICAL MOTOR ACTIVITY INDUCED BY ANAL STIMULATION. Acta Chir Scand. 1963 Sep;126:244–250. [PubMed] [Google Scholar]
  12. Langley J. N., Anderson H. K. On Reflex Action from Sympathetic Ganglia. J Physiol. 1894 May 29;16(5-6):410–440. doi: 10.1113/jphysiol.1894.sp000510. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Oliver J. E., Jr, Bradley W. E., Fletcher T. F. Spinal cord representation of the micturition reflex. J Comp Neurol. 1969 Nov;137(3):329–346. doi: 10.1002/cne.901370307. [DOI] [PubMed] [Google Scholar]
  14. Sundin T., Carlsson C. A., Kock N. G. Detrusor inhibition induced from mechanical stimulation of the anal region and from electrical stimulation of pudendal nerve afferents. An experimental study in cats. Invest Urol. 1974 Mar;11(5):374–378. [PubMed] [Google Scholar]
  15. Szurszewski J. H., Weems W. A. A study of peripheral input to and its control by post-ganglionic neurones of the inferior mesenteric ganglion. J Physiol. 1976 Apr;256(3):541–556. doi: 10.1113/jphysiol.1976.sp011338. [DOI] [PMC free article] [PubMed] [Google Scholar]

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