Abstract
The expected value of the squared linkage disequilibrium is derived for a neutral locus associated with a chromosomal arrangement that is maintained in the population by strong balancing selection. For a given value of recombination, the expected squared linkage disequilibrium is shown to decrease as the intensity of selection maintaining the arrangement increases. The transient behavior of the expected square linkage disequilibrium is also derived. This theory applies to loci that are closely linked to inversions in Drosophila species and to loci closely linked to the differential segments of the translocation complexes in ring-forming species of Oenothera. In both cases the strong linkage disequilibria that have been observed in natural populations can be explained by random drift.
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Selected References
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- KIMURA M., CROW J. F. THE NUMBER OF ALLELES THAT CAN BE MAINTAINED IN A FINITE POPULATION. Genetics. 1964 Apr;49:725–738. doi: 10.1093/genetics/49.4.725. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Kojima K., Gillespie J., Toari Y. N. A profile of Drosophila species' enzymes assayed by electrophoresis. I. Number of alleles, heterozygosities, and linkage disequilibrium in glucose-metabolizing systems and some other enzymes. Biochem Genet. 1970 Oct;4(5):627–637. doi: 10.1007/BF00486100. [DOI] [PubMed] [Google Scholar]
- Langley C. H., Tobari Y. N., Kojima K. I. Linkage disequilibrium in natural populations of Drosophila melanogaster. Genetics. 1974 Nov;78(3):921–936. doi: 10.1093/genetics/78.3.921. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Nei M., Li W. H. Probability of identical monomorphism in related species. Genet Res. 1975 Aug;26(1):31–43. doi: 10.1017/s0016672300015822. [DOI] [PubMed] [Google Scholar]
- Prakash S. Gene differences between third-chromosome inversions of Drosophila pseudobscura. Genetics. 1976 Dec;84(4):787–790. doi: 10.1093/genetics/84.4.787. [DOI] [PMC free article] [PubMed] [Google Scholar]
- de March Ayuela P. Tuberculosis activa en pacientes en hemodiálisis. Med Clin (Barc) 1983 Oct 22;81(12):545–546. [PubMed] [Google Scholar]