Skip to main content
NCBI home page
Genetics logoLink to Genetics
. 1983 Dec;105(4):921–933. doi: 10.1093/genetics/105.4.921

Genetic Control of Adh Expression in DROSOPHILA MELANOGASTER

G Maroni 1,2, C C Laurie-Ahlberg 1,2
PMCID: PMC1202234  PMID: 6416923

Abstract

Natural variants displaying different levels of expression of the gene for alcohol dehydrogenase (Adh) were subjected to genetic mapping experiments. The strains studied carry one of the two common electrophoretic forms of the enzyme. The difference among Adh-fast strains appears to be due to multiple loci with trans-acting effects. Differences among Adh-slow strains are due to modifiers or quantitative sites located very close to the structural gene (less than 0.05 map unit) or part of it. The modifiers detected in the Adhs strains seem to operate only on the structural allele in the cis-position.—A modifier that affects the ratio of ADH levels in larvae and adults was also detected in the Adhs strains. This modifier is also closely linked to Adh and is cis-acting.

Full Text

The Full Text of this article is available as a PDF (820.5 KB).

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Benyajati C., Spoerel N., Haymerle H., Ashburner M. The messenger RNA for alcohol dehydrogenase in Drosophila melanogaster differs in its 5' end in different developmental stages. Cell. 1983 May;33(1):125–133. doi: 10.1016/0092-8674(83)90341-0. [DOI] [PubMed] [Google Scholar]
  2. Chovnick A., Gelbart W., McCarron M., Osmond B. Organization of the rosy locus in Drosophila melanogaster: evidence for a control element adjacent to the xanthine dehydrogenase structural element. Genetics. 1976 Oct;84(2):233–255. doi: 10.1093/genetics/84.2.233. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Dickinson W. J., Carson H. L. Regulation of the tissue specificity of an enzyme by a cis-acting genetic element: evidence from interspecific Drosophila hybrids. Proc Natl Acad Sci U S A. 1979 Sep;76(9):4559–4562. doi: 10.1073/pnas.76.9.4559. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Grell E. H., Jacobson K. B., Murphy J. B. Alcohol Dehydrogenase in Drosophila melanogaster: Isozymes and Genetic Variants. Science. 1965 Jul 2;149(3679):80–82. doi: 10.1126/science.149.3679.80. [DOI] [PubMed] [Google Scholar]
  5. Kreitman M. Nucleotide polymorphism at the alcohol dehydrogenase locus of Drosophila melanogaster. Nature. 1983 Aug 4;304(5925):412–417. doi: 10.1038/304412a0. [DOI] [PubMed] [Google Scholar]
  6. Maroni G., Laurie-Ahlberg C. C., Adams D. A., Wilton A. N. Genetic variation in the expression of ADH in Drosophila melanogaster. Genetics. 1982 Jul-Aug;101(3-4):431–446. doi: 10.1093/genetics/101.3-4.431. [DOI] [PMC free article] [PubMed] [Google Scholar]

Articles from Genetics are provided here courtesy of Oxford University Press

RESOURCES