Abstract
In the present study an extensive amount of data, comprising more than 30,000 offspring in total, was analyzed to evaluate the influence of age and sex on the recombination frequency in the K-PGD segment of the equine linkage group (LG) I and the influence of age, breed and sex on recombination in the Al-Es segment of LG II. A highly significant sex difference is reported for both segments. Male and female recombination values in the K-PGD segment were estimated at 25.8 ± 0.8 and 33.3 ± 2.5%, respectively. Similarly, recombination was less frequent in the male (36.6 ± 0.7%) than in the female (46.6 ± 1.2%) in the Al-Es segment. Comparison of data from two Swedish horse breeds revealed no significant breed differences in either sex for recombination in the Al-Es segment. No evidence of an age effect was found in any segment or sex. The distribution of individual male recombination estimates was also investigated, and a significant heterogeneity among stallions was revealed in the K-PGD segment. The results are discussed in relation to previous studies on factors affecting recombination in mammals.
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Selected References
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- Andersson L., Juneja R. K., Sandberg K. Genetic linkage between the loci for phosphohexose isomerase (PHI) and a serum protein (Xk) in horses. Anim Blood Groups Biochem Genet. 1983;14(1):45–50. doi: 10.1111/j.1365-2052.1983.tb01059.x. [DOI] [PubMed] [Google Scholar]
- Andresen E. Linkage between the K blood-group locus and the Hp locus for hematin-binding globulins in pigs. Genetics. 1966 Sep;54(3):805–812. doi: 10.1093/genetics/54.3.805. [DOI] [PMC free article] [PubMed] [Google Scholar]
- MORTON N. E. Sequential tests for the detection of linkage. Am J Hum Genet. 1955 Sep;7(3):277–318. [PMC free article] [PubMed] [Google Scholar]
- REID D. H., PARSONS P. A. Sex of parent and variation of recombination with age in the mouse. Heredity (Edinb) 1963 Feb;18:107–108. doi: 10.1038/hdy.1963.9. [DOI] [PubMed] [Google Scholar]
- Rao D. C., Keats B. J., Morton N. E., Yee S., Lew R. Variability of human linkage data. Am J Hum Genet. 1978 Sep;30(5):516–529. [PMC free article] [PubMed] [Google Scholar]
- Sandberg K. Linkage between the K blood group locus and the 6-PGD locus in horses. Anim Blood Groups Biochem Genet. 1974;5(3):137–141. doi: 10.1111/j.1365-2052.1974.tb01323.x. [DOI] [PubMed] [Google Scholar]
- Wallace M. E., MacSwiney F. J., Edwards R. G. Parental age and recombination frequency in the house mouse. Genet Res. 1976 Dec;28(3):241–251. doi: 10.1017/s0016672300016931. [DOI] [PubMed] [Google Scholar]
- Weitkamp L. R. Proceedings: Population differences in meiotic recombination frequency between loci on chromosome 1. Cytogenet Cell Genet. 1974;13(1):179–182. doi: 10.1159/000130267. [DOI] [PubMed] [Google Scholar]
- Weitkamp L. R., Van Rood J. J., Thorsby E., Bias W., Fotino M., Lawler S. D., Dausset J., Mayr W. R., Bodmer J., Ward F. E. The relation of parental sex and age to recombination in the HL-A system. Hum Hered. 1973;23(3):197–205. doi: 10.1159/000152574. [DOI] [PubMed] [Google Scholar]