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. 1984 Oct;108(2):393–408. doi: 10.1093/genetics/108.2.393

The Genetic Structure of Natural Populations of DROSOPHILA MELANOGASTER. Xvii. a Population Carrying Genetic Variability Explicable by the Classical Hypothesis

Shinichi Kusakabe 1, Terumi Mukai 1
PMCID: PMC1202413  PMID: 17246232

Abstract

About 400 second chromosomes were extracted from the Aomori population, a northernmost population of D. melanogaster on Honshu in Japan, and the following experimental results were obtained. (1) The frequency of lethal chromosomes was 0.23. (2) The effective size of the population was estimated to be about 3000, from the allelism rate of lethal chromosomes and their frequency. (3) The detrimental and lethal loads for viability were 0.243 and 0.242, respectively, and the D/L ratio became 1.00. (4) The average degree of dominance for mildly deleterious genes was estimated to be 0.178 ± 0.056. (5) Additive (σ2A) and dominance (σ2D) variances of viability were estimated to be 0.00276 ± 0.00090 and 0.00011 ± 0.00014, respectively. (6) There was no significant difference in environmental variances between homozygotes and heterozygotes. Using these estimates, we discuss the maintenance mechanisms of genetic variability of viability in the population. The mutation-selection balance explained these experimental results.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Mettler L. E., Voelker R. A., Mukai T. Inversion Clines in Populations of DROSOPHILA MELANOGASTER. Genetics. 1977 Sep;87(1):169–176. doi: 10.1093/genetics/87.1.169. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Morton N. E., Crow J. F., Muller H. J. AN ESTIMATE OF THE MUTATIONAL DAMAGE IN MAN FROM DATA ON CONSANGUINEOUS MARRIAGES. Proc Natl Acad Sci U S A. 1956 Nov;42(11):855–863. doi: 10.1073/pnas.42.11.855. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Mukai T., Cardellino R. A., Watanabe T. K., Crow J. F. The genetic variance for viability and its components in a local population of Drosophila melanogaster. Genetics. 1974 Dec;78(4):1195–1208. doi: 10.1093/genetics/78.4.1195. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Mukai T., Nagano S. The Genetic Structure of Natural Populations of DROSOPHILA MELANOGASTER. Xvi. Excess of Additive Genetic Variance of Viability. Genetics. 1983 Sep;105(1):115–134. doi: 10.1093/genetics/105.1.115. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Mukai T. The Genetic Structure of Natural Populations of DROSOPHILA MELANOGASTER. Xiv. Effects of the Incomplete Dominance of the IN(2LR)SM1 (Cy) Chromosome on the Estimates of Various Genetic Parameters. Genetics. 1980 Jan;94(1):169–184. doi: 10.1093/genetics/94.1.169. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Mukai T. The genetic structure of natural populations of Drosophila melanogaster. 8. Natural selection on the degree of dominance of viability polygenes. Genetics. 1969 Oct;63(2):467–478. doi: 10.1093/genetics/63.2.467. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Mukai T., Yamazaki T. The genetic structure of natural populations of Drosophila melanogaster. V. Coupling-repulsion effect of spontaneous mutant polygenes controlling viability. Genetics. 1968 Aug;59(4):513–535. doi: 10.1093/genetics/59.4.513. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Shaw C. R., Prasad R. Starch gel electrophoresis of enzymes--a compilation of recipes. Biochem Genet. 1970 Apr;4(2):297–320. doi: 10.1007/BF00485780. [DOI] [PubMed] [Google Scholar]

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