Abstract
Previous maximum likelihood methods to analyze quantitative data on two inbred parental strains, their F1 and backcross generations are extended in three directions: (1) a method is suggested to transform the data to better satisfy the assumptions of normality and homoscedasticity; (2) the likelihoods are modified to allow for litter correlations and heteroscedasticity and (3) allowance is made for the incorporation of F2 data. The problem of making a choice among a set of simple genetic hypotheses is further discussed.
Full Text
The Full Text of this article is available as a PDF (682.5 KB).
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Stolk J. M., Vantini G., Guchhait R. B., Hurst J. H., Perry B. D., U'Prichard D. C., Elston R. C. Inheritance of adrenal phenylethanolamine N-methyltransferase activity in the rat. Genetics. 1984 Nov;108(3):633–649. doi: 10.1093/genetics/108.3.633. [DOI] [PMC free article] [PubMed] [Google Scholar]