Abstract
Published studies have reported significant selection with respect to the G6pd locus for Drosophila melanogaster reared on Na-octanoate food. We have reexamined the selective effects of Na-octanoate on egg to adult viability with respect to the G6pd polymorphism using specially constructed X chromosomes. Four experiments were carried out using different 6Pgd backgrounds in two recombinant sets of chromosomes segregating for the G6pd locus but constructed so as to minimize variation over most of the X chromosome. In addition, two measures of viability were used, and the size of the experiments and their associated degrees of freedom are approximately double those reported in the former studies. Our results find no evidence for differential selection on G6pd genotypes (males and females) by Na-octanoate and, therefore, do not corroborate the positive results of selection reported by other investigators. The reasons for our different results are discussed.
Full Text
The Full Text of this article is available as a PDF (643.8 KB).
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Ayala F. J., Anderson W. W. Evidence of natural selection in molecular evolution. Nat New Biol. 1973 Feb 28;241(113):274–276. doi: 10.1038/newbio241274a0. [DOI] [PubMed] [Google Scholar]
- Bijlsma R. Polymorphism at the G6PD and 6PGD loci in Drosophila melanogaster. II. Evidence for interaction in fitness. Genet Res. 1978 Jun;31(3):227–237. doi: 10.1017/s0016672300018012. [DOI] [PubMed] [Google Scholar]
- Clarke B. The contribution of ecological genetics to evolutionary theory: detecting the direct effects of natural selection on particular polymorphic loci. Genetics. 1975 Jun;79 (Suppl):101–113. [PubMed] [Google Scholar]
- Cochrane B. J., Lucchesi J. C., Laurie-Ahlberg C. C. Regulation of enzyme activities in Drosophila: genetic variation affecting induction of glucose 6-phosphate and 6-phosphogluconate dehydrogenase in larvae. Genetics. 1983 Nov;105(3):601–613. doi: 10.1093/genetics/105.3.601. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Hill W. G. Estimation of linkage disequilibrium in randomly mating populations. Heredity (Edinb) 1974 Oct;33(2):229–239. doi: 10.1038/hdy.1974.89. [DOI] [PubMed] [Google Scholar]
- Marinković D., Ayala F. J. Fitness of allozyme variants in Drosophila pseudoobscura. I. Selection at the PGM-1 and Me-2 loci. Genetics. 1975 Jan;79(1):85–95. doi: 10.1093/genetics/79.1.85. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Marinković D., Ayala F. J. Fitness of allozyme variants in Drosophila pseudoobscura. II. Selection at the Est-5, Odh and Mdh-2 loci. Genet Res. 1974 Oct;24(2):137–149. doi: 10.1017/s0016672300015172. [DOI] [PubMed] [Google Scholar]
- Miyashita N., Laurie-Ahlberg C. C. Genetical analysis of chromosomal interaction effects on the activities of the glucose 6-phosphate and 6-phosphogluconate dehydrogenases in Drosophila melanogaster. Genetics. 1984 Apr;106(4):655–668. doi: 10.1093/genetics/106.4.655. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Mukai T., Yamazaki T. Test for selection on polymorphic isozyme genes using the population cage method. Genetics. 1980 Oct;96(2):537–542. doi: 10.1093/genetics/96.2.537. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Williamson J. H., Bentley M. M. Comparative properties of three forms of glucose-6-phosphate dehydrogenase in Drosophila melanogaster. Biochem Genet. 1983 Dec;21(11-12):1153–1166. doi: 10.1007/BF00488467. [DOI] [PubMed] [Google Scholar]
- Yamazaki T., Kusakabe S., Tachida H., Ichinose M., Yoshimaru H., Matsuo Y., Mukai T. Reexamination of diversifying selection of polymorphic allozyme genes by using population cages in Drosophila melanogaster. Proc Natl Acad Sci U S A. 1983 Sep;80(18):5789–5792. doi: 10.1073/pnas.80.18.5789. [DOI] [PMC free article] [PubMed] [Google Scholar]