Abstract
Segregation Distorter, SD, associated with the second chromosome of Drosophila melanogaster, is known to cause sperm bearing the non-SD homologue to dysfunction in heterozygous males. In earlier studies, using different, independently derived, SD chromosomes, three major loci were identified as contributing to the distortion of segregation ratios in males. In this study the genetic components of the SD-5 chromosome have been the subjects of further investigation, and our findings offer the following information. Crossover analysis confirms the mapping of the Sd locus to a position distal to but closely linked with the genetic marker pr. Spontaneous and radiation-induced recombinational analyses and deficiency studies provide firm support to the notion that the Rsp (Responder) locus lies within the proximal heterochromatin of chromosome 2, between the genetic markers lt and rl and most likely in the heterochromatin of the right arm. The major focus of this study, however, has been on providing a better definition of the genetic properties of the Enhancer of SD [E(SD)]. Our findings place this locus within the region of the two most proximal essential genes in the heterochromatin of the left arm of chromosome 2. Moreover, our analysis reveals a probable association of the E(SD) locus with a meiotic drive independent of that caused by Sd.
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Selected References
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- Brittnacher J. G., Ganetzky B. On the Components of Segregation Distortion in DROSOPHILA MELANOGASTER. II. Deletion Mapping and Dosage Analysis of the SD Locus. Genetics. 1983 Apr;103(4):659–673. doi: 10.1093/genetics/103.4.659. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Hartl D. L. Genetic dissection of segregation distortion. I. Suicide combinations of SD genes. Genetics. 1974 Mar;76(3):477–486. doi: 10.1093/genetics/76.3.477. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Hauschteck-Jungen E., Hartl D. L. Defective Histone Transition during Spermiogenesis in Heterozygous SEGREGATION DISTORTER Males of DROSOPHILA MELANOGASTER. Genetics. 1982 May;101(1):57–69. doi: 10.1093/genetics/101.1.57. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Hilliker A. J., Holm D. G. Genetic analysis of the proximal region of chromosome 2 of Drosophila melanogaster. I. Detachment products of compound autosomes. Genetics. 1975 Dec;81(4):705–721. doi: 10.1093/genetics/81.4.705. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Hiraizumi Y. Heterochromatic recombination in germ cells of Drosophila melanogaster females. Genetics. 1981 May;98(1):105–114. doi: 10.1093/genetics/98.1.105. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Hiraizumi Y., Martin D. W., Eckstrand I. A. A Modified Model of Segregation Distortion in DROSOPHILA MELANOGASTER. Genetics. 1980 Jul;95(3):693–706. doi: 10.1093/genetics/95.3.693. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Kettaneh N. P., Hartl D. L. Histone transition during spermiogenesis is absent in segregation distorter males of Drosophila melanogaster. Science. 1976 Sep 10;193(4257):1020–1021. doi: 10.1126/science.821147. [DOI] [PubMed] [Google Scholar]
- Lyon M. F. Transmission ratio distortion in mouse t-haplotypes is due to multiple distorter genes acting on a responder locus. Cell. 1984 Jun;37(2):621–628. doi: 10.1016/0092-8674(84)90393-3. [DOI] [PubMed] [Google Scholar]
- Martin D. W., Hiraizumi Y. On the Models of Segregation Distortion in DROSOPHILA MELANOGASTER. Genetics. 1979 Oct;93(2):423–435. doi: 10.1093/genetics/93.2.423. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Tokuyasu K. T., Peacock W. J., Hardy R. W. Dynamics of spermiogenesis in Drosophila melanogaster. VII. Effects of segregation distorter (SD) chromosome. J Ultrastruct Res. 1977 Jan;58(1):96–107. doi: 10.1016/s0022-5320(77)80011-7. [DOI] [PubMed] [Google Scholar]