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. 1985 Nov;111(3):597–615. doi: 10.1093/genetics/111.3.597

Cellular Genes in the Mouse Regulate IN TRANS the Expression of Endogenous Mouse Mammary Tumor Viruses

Vicki L Traina-Dorge 1, Jean K Carr 1, Joan E Bailey-Wilson 1, Robert C Elston 1, Benjamin A Taylor 1, J Craig Cohen 1
PMCID: PMC1202660  PMID: 2996982

Abstract

The transcriptional activities of the eleven mouse mammary tumor virus (MMTV) proviruses endogenous to two sets of recombinant inbred (RI) mouse strains, BXD and BXH, were characterized. Comparison of the levels of virus-specific RNA quantitated in each strain showed no direct relationship between the presence of a particular endogenous provirus or with increasing numbers of proviruses. Association of specific genetic markers with the level of MMTV-specific RNA was examined by using multiple regression analysis. Several cellular loci as well as proviral loci were identified that were significantly associated with viral expression. Importantly, these cellular loci associated with MMTV expression segregated independently of viral sequences.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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