Skip to main content
PMC home page
Biochemical Journal logoLink to Biochemical Journal
. 1964 Apr;91(1):1.b2–8.

Nucleoside diphosphate sugars and saccharide synthesis. The fourth Hopkins Memorial Lecture

Luis F Leloir
PMCID: PMC1202807  PMID: 16749053

Full text

PDF
1-b2

Images in this article

1-b2p[1]-b2-a
on p.1-b2

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. ALGRANATI I. D., CABIB E. Uridine diphosphate D-glucose-glycogen glucosyltransferase from yeast. J Biol Chem. 1962 Apr;237:1007–1013. [PubMed] [Google Scholar]
  2. ALGRANATI I. D., CARMINATTI H., CABIB E. THE ENZYMIC SYNTHESIS OF YEAST MANNAN. Biochem Biophys Res Commun. 1963 Aug 20;12:504–509. doi: 10.1016/0006-291x(63)90324-3. [DOI] [PubMed] [Google Scholar]
  3. BADDILEY J. Teichoic acids in walls and cells of grampositive bacteria. Fed Proc. 1962 Nov-Dec;21:1084–1088. [PubMed] [Google Scholar]
  4. BARBER G. A. Enzymic glycosylation of quercetin to rutin. Biochemistry. 1962 May 25;1:463–468. doi: 10.1021/bi00909a015. [DOI] [PubMed] [Google Scholar]
  5. BURGER M. M., GLASER L. The enzymic synthesis of polyglycerophosphate. Biochim Biophys Acta. 1962 Nov 5;64:575–577. doi: 10.1016/0006-3002(62)90324-4. [DOI] [PubMed] [Google Scholar]
  6. BURGER M., GLASER L., BURTON R. M. The synthesis of a rhamnolipid by enzyme preparations from Pseudomonas aeruginosa. Biochim Biophys Acta. 1962 Jan 1;56:172–174. doi: 10.1016/0006-3002(62)90544-9. [DOI] [PubMed] [Google Scholar]
  7. CABIB E. CARBOHYDRATE METABOLISM. Annu Rev Biochem. 1963;32:321–354. doi: 10.1146/annurev.bi.32.070163.001541. [DOI] [PubMed] [Google Scholar]
  8. CABIB E., LELOIR L. F. Guanosine diphosphate mannose. J Biol Chem. 1954 Feb;206(2):779–790. [PubMed] [Google Scholar]
  9. CABIB E., LELOIR L. F. The biosynthesis of trehalose phosphate. J Biol Chem. 1958 Mar;231(1):259–275. [PubMed] [Google Scholar]
  10. CAPUTTO R., LELOIR L. F., CARDINI C. E., PALADINI A. C. Isolation of the coenzyme of the galactose phosphate-glucose phosphate transformation. J Biol Chem. 1950 May;184(1):333–350. [PubMed] [Google Scholar]
  11. CAPUTTO R., TRUCCO R. E. A new galactose-containing compound from mammary glands. Nature. 1952 Jun 21;169(4312):1061–1062. doi: 10.1038/1691061b0. [DOI] [PubMed] [Google Scholar]
  12. CARDINI C. E., LELOIR L. F., CHIRIBOGA J. The biosynthesis of sucrose. J Biol Chem. 1955 May;214(1):149–155. [PubMed] [Google Scholar]
  13. CARDINI C. E., YAMAHA T. Biosynthesis of plant glycosides from uridine diphosphate glucose. Nature. 1958 Nov 22;182(4647):1446–1447. doi: 10.1038/1821446a0. [DOI] [PubMed] [Google Scholar]
  14. CARMINATTI H., CABIB E. Phosphorolysis of the pyrophosphate bond of some nucleotides. Biochim Biophys Acta. 1961 Oct 28;53:417–419. doi: 10.1016/0006-3002(61)90458-9. [DOI] [PubMed] [Google Scholar]
  15. CLELAND W. W., KENNEDY E. P. The enzymatic synthesis of psychosine. J Biol Chem. 1960 Jan;235:45–51. [PubMed] [Google Scholar]
  16. DUTTON G. J., STOREY I. D. E. The isolation of a compound of uridine diphosphate and glucuronic acid from liver. Biochem J. 1953 Mar;53(4):xxxvii–xxxviii. [PubMed] [Google Scholar]
  17. FEINGOLD D. S., NEUFELD E. F., HASSID W. Z. Synthesis of a beta-1, 3-linked glucan by extracts of Phaseolus aureus seedlings. J Biol Chem. 1958 Oct;233(4):783–788. [PubMed] [Google Scholar]
  18. FEINGOLD D. S., NEUFELD E. F., HASSID W. Z. Xylosyl transfer catalyzed by an asparagus extract. J Biol Chem. 1959 Mar;234(3):488–489. [PubMed] [Google Scholar]
  19. FUKASAWA T., NIKAIDO H. Galactose-sensitive mutants of Salmonella. II. Bacteriolysis induced by galactose. Biochim Biophys Acta. 1961 Apr 15;48:470–483. doi: 10.1016/0006-3002(61)90045-2. [DOI] [PubMed] [Google Scholar]
  20. GANDER J. E., PETERSEN W. E., BOYER P. D. On the enzymic synthesis of lactose-1-PO4. Arch Biochem Biophys. 1957 Jul;69:85–99. doi: 10.1016/0003-9861(57)90476-9. [DOI] [PubMed] [Google Scholar]
  21. GLASER L., BROWN D. H. The enzymic synthesis of chitin by extracts of Neurospora crassa. Biochim Biophys Acta. 1957 Feb;23(2):449–450. doi: 10.1016/0006-3002(57)90361-x. [DOI] [PubMed] [Google Scholar]
  22. GLASER L., KORNFELD S. The enzymatic synthesis of thymidine-linked sugars. II. Thymidine diphosphate L-rhamnose. J Biol Chem. 1961 Jun;236:1795–1799. [PubMed] [Google Scholar]
  23. GLASER L. The enzymic synthesis of a ribitol 5-phosphate polymer. Biochim Biophys Acta. 1963 Apr 2;71:237–238. doi: 10.1016/0006-3002(63)91020-5. [DOI] [PubMed] [Google Scholar]
  24. GLASER L. The enzymic synthesis of cellulose by Acetobacter xylinum. Biochim Biophys Acta. 1957 Aug;25(2):436–436. doi: 10.1016/0006-3002(57)90501-2. [DOI] [PubMed] [Google Scholar]
  25. GLASSER L. Uridine diphosphate-N-acetylglucosamine-4-epimerase from Bacillus subtilis. Biochim Biophys Acta. 1959 Feb;31(2):575–576. doi: 10.1016/0006-3002(59)90046-0. [DOI] [PubMed] [Google Scholar]
  26. GOLDEMBERG S. H., MARECHAL L. R. Biosynthesis of paramylon in Euglena gracilis. Biochim Biophys Acta. 1963 Jun 4;71:743–744. doi: 10.1016/0006-3002(63)91155-7. [DOI] [PubMed] [Google Scholar]
  27. GOLDEMBERG S. H. Specificity of uridine diphosphate glucose-glycogen glucosyltransferase. Biochim Biophys Acta. 1962 Jan 29;56:357–359. doi: 10.1016/0006-3002(62)90576-0. [DOI] [PubMed] [Google Scholar]
  28. Ginsburg V., Neufeld E. F., Hassid W. Z. ENZYMATIC SYNTHESIS OF URIDINE DIPHOSPHATE XYLOSE AND URIDINE DIPHOSPHATE ARABINOSE. Proc Natl Acad Sci U S A. 1956 Jun;42(6):333–335. doi: 10.1073/pnas.42.6.333. [DOI] [PMC free article] [PubMed] [Google Scholar]
  29. HASHIMOTO T., TATIBANA M., ISHII Y., YOSHIKAWA H. Synthesis of adenylyl 2,3-diphosphoglyceric acid. J Biochem. 1961 Dec;50:548–549. doi: 10.1093/oxfordjournals.jbchem.a127490. [DOI] [PubMed] [Google Scholar]
  30. HASSID W. Z., DOUDOROFF M. Synthesis of disaccharides with bacterial enzymes. Adv Enzymol Relat Subj Biochem. 1950;10:123–143. doi: 10.1002/9780470122556.ch4. [DOI] [PubMed] [Google Scholar]
  31. HEATH E. C., ELBEIN A. D. The enzymatic synthesis of guanosine diphosphate colitose by a mutant strain of Escherichia coli. Proc Natl Acad Sci U S A. 1962 Jul 15;48:1209–1216. doi: 10.1073/pnas.48.7.1209. [DOI] [PMC free article] [PubMed] [Google Scholar]
  32. JACOBELLI G., TABONE J., TABONE D. La synthèse enzymatique de l'ester beta glucosidique de l'acide anthranilique: ses relations avec les processus de synthèse et de dégradation de l'uridine diphosphate glucose. Bull Soc Chim Biol (Paris) 1958;40(5-6):955–963. [PubMed] [Google Scholar]
  33. JACOBSON B., DAVIDSON E. A. UDP-D-glucuronic acid-5-epimerase and UDP-N-acetyglucosamine-4-epimerase of rabbit skin. Biochim Biophys Acta. 1963 May 7;73:145–151. doi: 10.1016/0006-3002(63)90429-3. [DOI] [PubMed] [Google Scholar]
  34. JDOURDIAN G. W., CARLSON D. M., ROSEMAN S. The enzymatic synthesis of sialyl-lactose. Biochem Biophys Res Commun. 1963 Feb 18;10:352–358. doi: 10.1016/0006-291x(63)90537-0. [DOI] [PubMed] [Google Scholar]
  35. JOSSE J., KORNBERG A. Glucosylation of deoxyribonucleic acid. III. alpha- and beta-Glucosyl transferases from T4-infected Escherichia coli. J Biol Chem. 1962 Jun;237:1968–1976. [PubMed] [Google Scholar]
  36. KALCKAR H. M., BRAGANCA B., MUNCH-PETERSEN H. M. Uridyl transferases and the formation of uridine diphosphogalactose. Nature. 1953 Dec 5;172(4388):1038–1038. [PubMed] [Google Scholar]
  37. KALCKAR H. M., BRAGANCA B., MUNCH-PETERSEN H. M. Uridyl transferases and the formation of uridine diphosphogalactose. Nature. 1953 Dec 5;172(4388):1038–1038. [PubMed] [Google Scholar]
  38. KALCKAR H. M. Uridinediphospho galactose; metabolism, enzymology, and biology. Adv Enzymol Relat Subj Biochem. 1958;20:111–134. doi: 10.1002/9780470122655.ch4. [DOI] [PubMed] [Google Scholar]
  39. KORNFELD S., GLASER L. The enzymic synthesis of thymidine-linked sugars. I. Thymidine diphosphate glucose. J Biol Chem. 1961 Jun;236:1791–1794. [PubMed] [Google Scholar]
  40. KORNFELD S., GLASER L. The synthesis of thymidine-linked sugars. v. thymidine diphosphate-amino sugars. J Biol Chem. 1962 Oct;237:3052–3059. [PubMed] [Google Scholar]
  41. Kosterlitz H. W. The structure of the galactosephosphate present in the liver during galactose assimilation. Biochem J. 1943 Sep;37(3):318–321. doi: 10.1042/bj0370318. [DOI] [PMC free article] [PubMed] [Google Scholar]
  42. LELOIR L. F., CARDINI C. E. The biosynthesis of sucrose phosphate. J Biol Chem. 1955 May;214(1):157–165. [PubMed] [Google Scholar]
  43. LELOIR L. F., DE FEKETE M. A., CARDINI C. E. Starch and oligosaccharide synthesis from uridine diphosphate glucose. J Biol Chem. 1961 Mar;236:636–641. [PubMed] [Google Scholar]
  44. LELOIR L. F., GOLDEMBERG S. H. Synthesis of glycogen from uridine diphosphate glucose in liver. J Biol Chem. 1960 Apr;235:919–923. [PubMed] [Google Scholar]
  45. LELOIR L. F., OLAVARRIA J. M., GOLDEMBERG S. H., CARMINATTI H. Biosynthesis of glycogen from uridine diphosphate glucose. Arch Biochem Biophys. 1959 Apr;81(2):508–520. doi: 10.1016/0003-9861(59)90232-2. [DOI] [PubMed] [Google Scholar]
  46. LELOIR L. F. The enzymatic transformation of uridine diphosphate glucose into a galactose derivative. Arch Biochem Biophys. 1951 Sep;33(2):186–190. doi: 10.1016/0003-9861(51)90096-3. [DOI] [PubMed] [Google Scholar]
  47. MALEY F., MALEY G. F. The enzymic conversion of glucosamine to galactosamine. Biochim Biophys Acta. 1959 Feb;31(2):577–578. doi: 10.1016/0006-3002(59)90047-2. [DOI] [PubMed] [Google Scholar]
  48. MILLS G. T., ONDARZA R., SMITH E. E. The uridyl transferase of liver. Biochim Biophys Acta. 1954 May;14(1):159–160. doi: 10.1016/0006-3002(54)90151-1. [DOI] [PubMed] [Google Scholar]
  49. MUNCH-PETERSEN A., KALCKAR H. M., CUTOLO E., SMITH E. E. Uridyl transferases and the formation of uridine triphosphate; enzymic production of uridine triphosphate: uridine diphosphoglucose pyrophosphorolysis. Nature. 1953 Dec 5;172(4388):1036–1037. doi: 10.1038/1721036a0. [DOI] [PubMed] [Google Scholar]
  50. NEUFELD E. F., GINSBURG V., PUTMAN E. W., FANSHIER D., HASSID W. Z. Formation and interconversion of sugar nucleotides by plant extracts. Arch Biochem Biophys. 1957 Jul;69:602–616. doi: 10.1016/0003-9861(57)90524-6. [DOI] [PubMed] [Google Scholar]
  51. NIKAIDO H. Galactose-sensitive mutants of Salmonella. I. Metabolism of galactose. Biochim Biophys Acta. 1961 Apr 15;48:460–469. doi: 10.1016/0006-3002(61)90044-0. [DOI] [PubMed] [Google Scholar]
  52. NIKAIDO H., JOKURA K. Isolation of cytidine diphosphate 3,6-dideoxyhexoses from Salmonella. Biochem Biophys Res Commun. 1961 Nov 29;6:304–309. doi: 10.1016/0006-291x(61)90384-9. [DOI] [PubMed] [Google Scholar]
  53. NIKAIDO H. Studies on the biosynthesis of cell wall polysaccharide in mutant strains of Salmonella. II. Proc Natl Acad Sci U S A. 1962 Sep 15;48:1542–1548. doi: 10.1073/pnas.48.9.1542. [DOI] [PMC free article] [PubMed] [Google Scholar]
  54. OSBORN M. J., ROSEN S. M., ROTHFIELD L., HORECKER B. L. Biosynthesis of bacterial lipopolysaccharide. I. Enzymatic incorporation of galactose in a mutant strain of Salmonella. Proc Natl Acad Sci U S A. 1962 Oct 15;48:1831–1838. doi: 10.1073/pnas.48.10.1831. [DOI] [PMC free article] [PubMed] [Google Scholar]
  55. PARK J. T. Uridine-5'-pyrophosphate derivatives. III. Amino acid-containing derivatives. J Biol Chem. 1952 Feb;194(2):897–904. [PubMed] [Google Scholar]
  56. PAZUR J. H., SHUEY E. W. The enzymatic synthesis of thymidine diphosphate glucose and its conversion to thymidine diphosphate rhamnose. J Biol Chem. 1961 Jun;236:1780–1785. [PubMed] [Google Scholar]
  57. PREISS J. Enzymatic oxidation of guanosine diphosphomannose to guanosine diphosphomannuronate. Biochem Biophys Res Commun. 1962 Oct 17;9:235–239. doi: 10.1016/0006-291x(62)90065-7. [DOI] [PubMed] [Google Scholar]
  58. RECONDO E., DANKERT M., LELOIR L. F. Isolation of adenosine diphosphate D-glucose from corn grains. Biochem Biophys Res Commun. 1963 Jul 26;12:204–207. doi: 10.1016/0006-291x(63)90190-6. [DOI] [PubMed] [Google Scholar]
  59. RECONDO E., LELOIR L. F. Adenosine diphosphate glucose and starch synthesis. Biochem Biophys Res Commun. 1961 Nov 1;6:85–88. doi: 10.1016/0006-291x(61)90389-8. [DOI] [PubMed] [Google Scholar]
  60. RONGINE DE FEKETE M. A., LELOIR L. F., CARDINI C. E. Mechanism of starch biosynthesis. Nature. 1960 Sep 10;187:918–919. doi: 10.1038/187918a0. [DOI] [PubMed] [Google Scholar]
  61. ROSEMAN S. Metabolism of sialic acids and d-mannosamine. Fed Proc. 1962 Nov-Dec;21:1075–1083. [PubMed] [Google Scholar]
  62. SHAW D. R. Pyrophosphorolysis and enzymic synthesis of cytidine diphosphate glycerol and cytidine diphosphate ribitol. Biochem J. 1962 Feb;82:297–312. doi: 10.1042/bj0820297. [DOI] [PMC free article] [PubMed] [Google Scholar]
  63. SLODKI M. E. Phosphate linkages in phosphomannans from yeast. Biochim Biophys Acta. 1962 Mar 12;57:525–533. doi: 10.1016/0006-3002(62)91160-5. [DOI] [PubMed] [Google Scholar]
  64. SLODKI M. E. Structure of Hansenula capsulata NRRL Y-1842 phosphomannan. Biochim Biophys Acta. 1963 Jan 1;69:96–102. doi: 10.1016/0006-3002(63)91229-0. [DOI] [PubMed] [Google Scholar]
  65. SMITH E. E., MILLS G. T., BERNHEIMER H. P., AUSTRIAN R. The presence of an uronic acid epimerase in a strain of pneumococcus type I. Biochim Biophys Acta. 1958 Sep;29(3):640–641. doi: 10.1016/0006-3002(58)90023-4. [DOI] [PubMed] [Google Scholar]
  66. STOREY I. D., DUTTON G. J. Uridine compounds in glucuronic acid metabolism. 2. The isolation and structure of 'uridine-diphosphate-glucuronic acid'. Biochem J. 1955 Feb;59(2):279–288. doi: 10.1042/bj0590279. [DOI] [PMC free article] [PubMed] [Google Scholar]
  67. STROMINGER J. L. Biosynthesis of bacterial cell walls. Fed Proc. 1962 Jan-Feb;21:134–143. [PubMed] [Google Scholar]
  68. STROMINGER J. L., MAPSON L. W. Uridine diphosphoglucose dehydrogenase of pea seedlings. Biochem J. 1957 Aug;66(4):567–572. doi: 10.1042/bj0660567. [DOI] [PMC free article] [PubMed] [Google Scholar]
  69. STROMINGER J. L. Uridine and guanosine nucleotides of hen oviduct. J Biol Chem. 1962 May;237:1388–1392. [PubMed] [Google Scholar]
  70. SU J. C., HASSID W. Z. Carbohydrates and nucleotides in the red alga Porphyra perforata. I. Isolation and identification of carbohydrates. Biochemistry. 1962 May 25;1:468–474. doi: 10.1021/bi00909a016. [DOI] [PubMed] [Google Scholar]
  71. SUZUKI S. A novel uridine nucleotide containing N-acetyl-glucosamine and galactose. J Biol Chem. 1962 May;237:1393–1399. [PubMed] [Google Scholar]
  72. TAKAHASHI N., SUZUKI S. Isolation of uridine diphosphate N-acetylglucosamine-6-fucose from hen oviduct. Biochim Biophys Acta. 1962 Sep 24;63:344–345. doi: 10.1016/0006-3002(62)90691-1. [DOI] [PubMed] [Google Scholar]
  73. TRIVELLONI J. C., RECONDO E., CARDINI C. E. Adenosine diphosphate glucose and glucoside biosynthesis. Nature. 1962 Sep 22;195:1202–1202. doi: 10.1038/1951202a0. [DOI] [PubMed] [Google Scholar]
  74. WARREN L., BLACKLOW R. S. Biosynthesis of N-acetyl-neuraminic acid and cytidine-5'-monophospho-N-acetyl-neuraminic acid in Neisseria meningitidis. Biochem Biophys Res Commun. 1962 Jun 4;7:433–438. doi: 10.1016/0006-291x(62)90330-3. [DOI] [PubMed] [Google Scholar]
  75. WATKINS W. M., HASSID W. Z. Enzymatic synthesis of lactose from uridine diphosphate D-galactose and D-glucose. Biochem Biophys Res Commun. 1961 Jul 26;5:260–264. doi: 10.1016/0006-291x(61)90158-9. [DOI] [PubMed] [Google Scholar]
  76. WOOD H. G., SCHAMBYE P., PEETERS G. J. Lactose synthesis. II. The distribution of C14 in lactose of milk from the perfused isolated cow udder. J Biol Chem. 1957 Jun;226(2):1023–1034. [PubMed] [Google Scholar]
  77. YAMAHA T., CARDINI C. E. The biosynthesis of plant glycosides. II. Gentiobiosides. Arch Biochem Biophys. 1960 Jan;86:133–137. doi: 10.1016/0003-9861(60)90380-5. [DOI] [PubMed] [Google Scholar]
  78. ZELEZNICK L. D., BOLTRALIK J. J., BARKULIS S. S., SMITH C., HEYMANN H. Biosynthesis of streptococcal cell walls: A rhamnose polysaccharide. Science. 1963 Apr 26;140(3565):400–401. doi: 10.1126/science.140.3565.400. [DOI] [PubMed] [Google Scholar]

Articles from Biochemical Journal are provided here courtesy of The Biochemical Society

RESOURCES